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Materials and Devices for Micro-invasive Neural Interfacing

Published online by Cambridge University Press:  18 November 2019

Khalil B. Ramadi Open the ORCID record for Khalil B. Ramadi [Opens in a new window]  and
Michael J. Cima
Khalil B. Ramadi*
Affiliation:
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139. Harvard–MIT Health Sciences and Technology Division, Massachusetts Institute of Technology, Cambridge, MA 02139.
Michael J. Cima
Affiliation:
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139. Harvard–MIT Health Sciences and Technology Division, Massachusetts Institute of Technology, Cambridge, MA 02139. Department of Materials Science, Massachusetts Institute of Technology, Cambridge, MA 02139.
*
*(Email: kramadi@mit.edu)
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Abstract

There is widespread research and popular interest in developing micro-invasive neural interfacing modalities. An increasing variety of probes have been developed and reported in the literature. Newer, smaller probes show significant benefit over larger ones in reducing tissue damage and scarring. A different set of obstacles arise, however, as probes become smaller. These include reliable insertion and robustness. This review articulates the impact of various design parameters (material, geometry, size) on probe insertion mechanisms, chronic viability, and glial scarring. We highlight various emerging technologies utilizing novel form factors including micron-scale interfaces and bio-inspired designs for probe insertion and steering.

Keywords

biomedicalbiomimetic

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MRS Advances , Volume 4 , Issue 51-52: Snapshot reviews in Materials Advances 2019 , 2019 , pp. 2805 - 2816
Copyright
Copyright © Materials Research Society 2019 

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References

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