Hostname: page-component-7b7567c8c-tnzcf Total loading time: 0 Render date: 2026-11-13T08:08:56.424Z Has data issue: false hasContentIssue false
  • English
  • Français

Rheological Characterization of Alginate Based Hydrogels for Tissue Engineering

Published online by Cambridge University Press:  10 January 2017

Pengfei Duan,
Nehir Kandemir,
Jiajun Wang and
Jinju Chen
Pengfei Duan
Affiliation:
School of Mechanical and Systems Engineering, Newcastle University, Newcastle upon Tyne, UKSchool of Chemical Engineering and Advanced Materials, Newcastle University, Newcastle upon Tyne, UK
Nehir Kandemir
Affiliation:
School of Mechanical and Systems Engineering, Newcastle University, Newcastle upon Tyne, UK
Jiajun Wang
Affiliation:
School of Mechanical and Systems Engineering, Newcastle University, Newcastle upon Tyne, UK
Jinju Chen*
Affiliation:
School of Mechanical and Systems Engineering, Newcastle University, Newcastle upon Tyne, UK
*
† Corresponding author: E-mail: Jinju.chen@ncl.ac.uk

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the 'Save PDF' action button.

Hydrogels have been widely used in many applications from tissue engineering to drug delivery systems. For both tissue engineering and drug delivery, the mechanical properties are important because they would affect cell-materials interactions and injectability of drugs encapsulated in hydrogel carriers. Therefore, it is important to study the mechanical properties of these hydrogels, particularly at physiological temperature (37°C). This study adopted strain sweep and frequency sweep rotational rheological tests to investigate the rheological characteristics of various tissue engineering relevant hydrogels with different concentrations at 37°C. These hydrogels include alginate, RGD-alginate, and copolymerized collagen/alginate/fibrin. It has revealed that the addition of RGD has negligible effect on the elastic modulus and viscosity of alginate. Alginate gels have demonstrated shear thinning behavior which indicates that they are suitable candidates as carriers for cells or drug delivery. The addition of collagen and fibrin would reinforce the mechanical properties of alginate which makes it a strong scaffold material.

Keywords

biomaterialpolymerviscoelasticity

Information

Type
Articles
Information
MRS Advances , Volume 2 , Issue 24: Biomaterials and Soft Materials , 2017, pp. 1309 - 1314
Copyright
Copyright © Materials Research Society 2017 

Footnotes

*

These two authors contribute equally to this manuscript.

References

REFERENCES

Vlierberghe, S. V., Dubruel, P. and Schacht, E., Biomacromolecules 12(5), 1387 (2011).Google Scholar
Lee, K. Y. and Mooney, D. J., Chem. Rev. 101(7), pp. 1869–1880 (2001).CrossRefGoogle Scholar
Kuo, C. K. and Ma, P. X., Biomaterials 22(6), 511 (2001).CrossRefGoogle Scholar
Martinsen, A., Skjåk-Bræk, G. and Smidsrød, O., Biotechnol. Bioeng. 33(1), 79 (1989).Google Scholar
Klöck, G., Pfeffermann, A., Ryser, C., Gröhn, P., Kuttler, B., Hahn, H. J. and Zimmermann, U., Biomaterials 18(10), 707 (1997).CrossRefGoogle Scholar
Gombotz, W. R. and Wee, S. F., Adv. Drug Delivery Rev. 64, 194 (2012).Google Scholar
Rowley, J. A., Madlambayan, G. and Mooney, D. J., Biomaterials 20(1), 45 (1999).Google Scholar
Fratzl, P. (Ed.), Collagen: Structure and Mechanics, 1st ed (Springer, New York, 2008), p.1–13.Google Scholar
Stagg, S. J., Pollot, B. E., Rathbone, C. R., Ong, A. and Guda, T., Interpenetrating Collagen-Fibrin Hydrogels for Skeletal Muscle Regeneration, WWW Document, (http://2015.biomaterials.org/sites/default/files/abstracts/608.pdf), [Accessed 22 04 2016].Google Scholar
Chen, J., Irianto, J., Inamdar, S., Pravincumar, P., Lee, D. A., Bader, D. L. and Knight, M. M., Biophys. J. 103(6), 1188 (2012).Google Scholar
Funami, T., Fang, Y., Noda, S., Ishihara, S., Nakauma, M., Draget, K. I., Nishinari, K. and Phillips, G. O., Food Hydrocoll. 23(7), 1746 (2009).Google Scholar
Knapp, D. M., Barocas, V. H., Moon, A. G., Yoo, K., Petzold, L. R. and Tranquillo, R. T., J. Rheol. 41(5), 971 (1998).Google Scholar
da Cunha, C. B. e. a., Biomaterials 35(32), 8927 (2014).Google Scholar