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SiC RF Sensor for Continuous Glucose Monitoring

Published online by Cambridge University Press:  23 May 2016

Fabiola Araujo Cespedes,
Gokhan Mumcu and
Stephen E. Saddow
Fabiola Araujo Cespedes*
Affiliation:
Electrical Engineering Dept., University of South Florida, 4200 E. Fowler Ave., Tampa, FL
Gokhan Mumcu
Affiliation:
Electrical Engineering Dept., University of South Florida, 4200 E. Fowler Ave., Tampa, FL
Stephen E. Saddow
Affiliation:
Electrical Engineering Dept., University of South Florida, 4200 E. Fowler Ave., Tampa, FL
*
*(Email: fabiola@mail.usf.edu)
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Abstract

It has been shown that changes in blood glucose can be sensed with an RF antenna made from silicon carbide (SiC) operating at 10 GHz. Therefore a SiC antenna patch could operate as an active sensor or as a passive sensor at 5.8 GHz for a continuous glucose monitoring system. The properties of SiC make this material ideal for biomedical applications and devices as it is not only biocompatible but also has great sensing capability. The permittivity and conductivity of the blood is glucose dependent. Thus implanting the antenna in the fatty tissue facing the muscle and blood results should result in a shift of the resonant frequency of the antenna with glucose levels. In the active sensor approach, a power supply and internal in-vivo circuitry with protection would be required. In the passive sensor approach, external circuitry sends a signal to the implanted antenna and is received back again, detecting any signal variations. Simulations in HFSS™ show that that an implanted sensor placed 2 mm from the muscle in fatty tissue would experience an approximate shift in resonant frequency of 12.3 MHz for a blood glucose change of 500 mg/dl.

Keywords

biomedicalsensorsimulation

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Type
Articles
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MRS Advances , Volume 1 , Issue 55: Electronics and Photonics , 2016, pp. 3691 - 3696
Copyright
Copyright © Materials Research Society 2016 

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References

REFERENCES

"Executive Summary: Standards of Medical Care in Diabetes—2013," Diabetes Care, vol. 36, pp. S4-S10, January 1, 2013 2013.CrossRefGoogle Scholar
Myers, W.. (2013). Managing Diabetes With Continuous Glucose Monitoring. Available: http://www.everydayhealth.com/diabetes/managing-diabetes-with-continuous-glucose-monitoring.aspx Referenced on 04/01/2016Google Scholar
Holt, P., "Blood glucose monitoring in diabetes," Nursing Standard, vol. 28, pp. 52–58, 2014/03/11 2014.CrossRefGoogle Scholar
Czupryniak, L., Barkai, L., Bolgarska, S., Bronisz, A., Broz, J., Cypryk, K., et al. , "Self-Monitoring of Blood Glucose in Diabetes: From Evidence to Clinical Reality in Central and Eastern Europe—Recommendations from the International Central-Eastern European Expert Group," Diabetes Technology & Therapeutics, vol. 16, pp. 460–475, 2014.CrossRefGoogle Scholar
Oliver, N. S., Toumazou, C., Cass, A. E. G., and Johnston, D. G., "Glucose sensors: a review of current and emerging technology," Diabetic Medicine, vol. 26, pp. 197–210, 2009.CrossRefGoogle Scholar
Onuki, Y., Bhardwaj, U., Papadimitrakopoulos, F., and Burgess, D. J., "A Review of the Biocompatibility of Implantable Devices: Current Challenges to Overcome Foreign Body Response," Journal of diabetes science and technology (Online), vol. 2, pp. 1003–1015, 11/ 2008.CrossRefGoogle Scholar
Koschwanez, H. E. and Reichert, W. M., "In Vitro, In Vivo and Post Explantation Testing of Glucose-Detecting Biosensors: Current Methods and Recommendations," Biomaterials, vol. 28, pp. 3687–3703, 04/19 2007.CrossRefGoogle Scholar
SADDOW, S. E. (ed.) Silicon Carbide Biotechnology: A Biocompatible Semiconductor for Advanced Biomedical Devices and Applications, Amsterdam: Elsevier (2011)Google Scholar
Afroz, S., Thomas, S. W., Saddow, S. E., Mumcu, G., and Topsakal, E., "IMPLANTABLE BIOCOMPATIBLE SiC SENSORS," ed: Google Patents, 2015.Google Scholar
Afroz, S., "A Biocompatible SiC RF Antenna for In-vivo Sensing Applications," Ph.D., Electrical Engineering, University of South Florida, 2013.CrossRefGoogle Scholar
Afroz, S., Thomas, S. W., Mumcu, G., and Saddow, S. E., "Implantable SiC based RF antenna biosensor for continuous glucose monitoring," in IEEE Sensors, Baltamore, Maryland USA, 2013.Google Scholar
Frewin, C. L., Locke, C., Saddow, S. E., and Weeber, E. J., "Single-Crystal Cubic Silicon Carbide: An in vivo biocompatible semiconductor for brain machine interface devices," in Engineering in Medicine and Biology Society,EMBC, 2011 Annual International Conference of the IEEE, Boston, MA, 2011, pp. 2957–60.CrossRefGoogle Scholar
Frewin, C. L., Locke, C., Mariusso, L., Weeber, E. J., and Saddow, S. E., "Silicon Carbide Neural Implants: in vivo Neural Tissue Reaction," Neural Engineering (NER), 6th International IEEE/EMBS Conference on, pp. 661–664, 2013.Google Scholar
Medical implant communications service federal register, Rules and Regulations., vol. 64, no. 240, pp. 69926–69934, Dec. 1999.Google Scholar
CHEUNG, R. Silicon Carbide Microelectromechanical Systems for Harsh Environments, Imperial College Press. p. 3. (2006)CrossRefGoogle Scholar
IEEE Standard for Local and Metropolitan Area Networks: Wireless Body Area Networks, IEEE Standard 802.15.6, (2012)Google Scholar
IEEE Standard for Safety Levels with Respect to Human Exposure to Radio Frequency Electromagnetic Fields, 3kHz to 300 Ghz, IEEE Standar C95.1–2005, 2006.Google Scholar
KARACOLAK, T., HOOD, A., TOPSAKAL, E., Design of a Dual-Band Implantable Antenna and Development of Skin Mimicking Gels for Continous Glucose Monitoring. IEEE Transactions on Microwave Theory and Techniques, Vol. 56-4, (2008).CrossRefGoogle Scholar
Kiourti, A. & Nikita, K. Implantable Antennas. IEEE Microwave Magazine. 1527-3342 (2014)Google Scholar
Kiourti, A., Costa, J., Fernandes, C., Nikita, K. A Broadband Implantable and Dual-Band On-Body Repeater Antenna: Design and Transmission Performance. IEEE Transactions on Antennas and Propagation, Vol 62, No. 6 (2014)CrossRefGoogle Scholar
Liu, C., Guo, Y., Xiao, S. Compact Dual-Band Antenna for Implantable Devices. IEEE Antannas and Wireless Propagation Letters. Vol. 11 (2012)Google Scholar
Duan, Z., Guo, Y., Je, M., Kwong, D. Design and in Vitro Test of a Differentially Fed Dual-Band Implantable Antenna Operating at MICS and ISM Bands.Google Scholar
Kiourti, A., Psathas, K, Costa, J., Fernandes, C., Nikita, K. Dual-Band Implantable Antennas for Medical Telemetry: A Fast Design Methodology and Validation for Intra-Cranial Pressure Monitoring. Progress in Electromagnetics Research, Vol. 141, 161–183 (2013)CrossRefGoogle Scholar
Noroozi, Z., Hojjat-Kahani, F. Three Dimensional FDTD Analysis of the Dual-Band Implantable Antenna For Continuous Glucose Monitoring. Progress In Electromagnetics Research Letters, Vol. 28, 9–21. (2012)CrossRefGoogle Scholar
Seran, S., Karacolak, T., Donohoe, J. A Small Implantable Dual Band Biocompatible Antenna for Medical Wireless Telemetry Applications. IEEE (2013)Google Scholar
Mohammed, Y. E. and Saber, A. G., “Estimation of E-Field inside Muscle Tissue at MICS and ISM Frequencies Using Analytic and Numerical Methods” Journal of Biomedical Engineering and Technology, 2014, Vol. 2, No. 3, 29–33 Google Scholar
Topsakal, E., Karacolak, T. and Moreland, E. C., "Glucose-dependent dielectric properties of blood plasma," General Assembly and Scientific Symposium, 2011 URSI, Istanbul, 2011, pp. 1–4. doi: 10.1109/URSIGASS.2011.6051324 Google Scholar
HFSS Ansys. http://easc.ansys.com/Products/Electronics/ANSYS+HFSS/Features/ Referenced on 04/01/2016Google Scholar
Saddow, SE, Coletti, C, Frewin, C, Castro, N, Oliveros, A and Jaroszeski, M, “Single-crystal Silicon Carbide: A Biocompatible and Hemocompatible Semiconductor for Advanced Biomedical Applications” MRS Proceedings 1246, 1246–B08-08 (2010)CrossRefGoogle Scholar