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Electrofluidic Positioning of Biofunctionalized Nanowires

Published online by Cambridge University Press:  01 February 2011

Thomas J. Morrow,
Jaekyun Kim,
Mingwei Li,
Theresa S. Mayer and
Christine D. Keating
Thomas J. Morrow
Affiliation:
tjm344@psu.edu, The Pennsylvania State University, Chemistry, University Park, United States
Jaekyun Kim
Affiliation:
jxk473@psu.edu, The Pennsylvania State University, Electrical Engineering, University Park, United States
Mingwei Li
Affiliation:
mingwei_li@agilent.com, The Pennsylvania State University, Electrical Engineering, University Park, United States
Theresa S. Mayer
Affiliation:
tsm2@psu.edu, The Pennsylvania State University, Electrical Engineering, University Park, United States
Christine D. Keating
Affiliation:
keating@chem.psu.edu, The Pennsylvania State University, Chemistry, University Park, United States
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Abstract

We functionalized nanowires with three different probe peptide nucleic acid (PNA) sequences, and assembled the three populations onto a lithographically patterned chip. Electrofluidic assembly enabled positioning each set of nanowires to span a different pair of guiding electrodes. Fluorescence imaging was used to probe whether the PNA on the individual nanowires remained able to selectively bind complementary DNA targets following assembly and integration of the positioned nanowires onto the chip surface.

Keywords

nanostructurelithography (deposition)sensor

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