Hostname: page-component-7b7567c8c-fvjsw Total loading time: 0 Render date: 2026-11-15T08:20:44.698Z Has data issue: false hasContentIssue false
  • English
  • Français

Insulating Biomaterials Research for Implantable Microelectronic Devices

Published online by Cambridge University Press:  15 February 2011

David J. Edell
David J. Edell*
Affiliation:
InnerSea Technology 1 DeAngelo Drive, Suite E Bedford, MA 01730
Get access

Abstract

Developments in the field of BioMEMS share many of the same issues encountered in the development of neural interface technology that has been underway for many decades. In addition to issues of function, other issues such as biocompatibility and bioresistance have also presented great challenges. The focus of this paper is on the development and testing of electrically insulating biomaterials for micro-devices that can be implanted in biological systems. A variety of accelerated degradation and accelerated detection of degradation techniques have been developed and are used to screen candidate materials. Direct tests of mechanical properties, adhesion, and chemical resistance are used for further assessment. Promising materials indicate what chemistry might be suitable for development of a Chemical Vapor Deposited (CVD) thin film coating. CVD coatings are under development that may be useful for insulation of very small, micromachined elements of an implantable device while only increasing the size of the device by a few micrometers. Materials passing in-vitro testing are then considered for in-vivo testing. Novel instrumentation for testing devices in-vivo has been developed.

Information

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 773: Symposium N – Biomicroelectromechanical Systems (BioMEMS) , 2003, N1.9
Copyright
Copyright © Materials Research Society 2003

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

1.Agnew, W.F. and McCreery, D.B., Neural Prostheses – Fundamental Studies. 1990, New Jersey: Prentice Hall.Google Scholar
2.Edell, D.J., Insulating Biomaterials, in Neuroprosthetics: Theory and Practice, Dhillon, K.H.a.G., Editor. in Publication for 2003.Google Scholar
3.Edell, D.J. and Gleason, K.K., Insulating Biomaterials. 2003, InnerSea Technology: http://www.ninds.nih.gov/qpr/electrode/qpr_electrode.html.Google Scholar
4.NAMSA Testing Service: http://www.namsa.com/.Google Scholar
5.Wise, K.D., Angell, J.B., and Starr, A., An integrated-circuit approach to extracellular microelectrodes. IEEE Trans Biomed Eng, 1970. 17(3): p. 238–47.Google Scholar
6.Najafi, K., Wise, K.D., and Mochizuki, T., A High-yield IC-compatible Multichannel Recording Array. IEEE Trans. Electron Devices, 1985. 32: p. 1206–1211.Google Scholar
7.Campbell, P.K., et al., A chronic intracortical electrode array: Preliminary results. J. BIomed. Mater. Res.: Applied Biomaterials, 1989. 23(A2): p. 245–259.Google Scholar
8.Edell, D.J., Development of a Chronic Neuroelectric Interface, in Biomedical Engineering. 1980, University of California: Davis.Google Scholar
9.Kovacs, G.T., Storment, C.W., and Rosen, J.M., Regeneration microelectrode array for peripheral nerve recording and stimulation. IEEE Trans Biomed Eng, 1992. 39(9): p. 893–902.Google Scholar
10.Murthy, S., Edell, D.J., and Gleason, K.K., Vapor Deposition of Biopassivation Coatings for Neuroprostheses, in Neuroprosthetics: Theory and Practice, Horch, K. and Dhillon, G., Editors. In Publication for 2003.Google Scholar