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Ionic Polyurethanes: Surface and Blood-Contacting Properties

Published online by Cambridge University Press:  26 February 2011

Ann Z. Okkema,
Thomas A. Giroux,
Timothy G. Grasel and
Stuart L. Cooper
Ann Z. Okkema
Affiliation:
University of Wisconsin, Department of Chemical Eng., 1415 Johnson Dr., Madison, WI 53706
Thomas A. Giroux
Affiliation:
University of Wisconsin, Department of Chemical Eng., 1415 Johnson Dr., Madison, WI 53706
Timothy G. Grasel
Affiliation:
University of Wisconsin, Department of Chemical Eng., 1415 Johnson Dr., Madison, WI 53706
Stuart L. Cooper
Affiliation:
University of Wisconsin, Department of Chemical Eng., 1415 Johnson Dr., Madison, WI 53706
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Abstract

Sulfonated polyetherurethanes, synthesized by the substitution of 0, 5, 10, 15, and 20% of the urethane nitrogens with propane sultone, were evaluated in this study. The water absorption properties are dramatically affected by the sulfonate content. The surface properties are also found to be influenced by the percentage of sulfonate incorporation. The blood-contacting properties, as determined by both an acute and chronic canine ex vivo experiment, show increased thromboresistance with increased propyl sulfonate incorporation. A unique characteristic of the highly sulfonated polymers is the negligible platelet activation and spreading observed using scanning electron microscopy.

Information

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 110: Symposium M – Biomedical Materials and Devices , 1987, 91
Copyright
Copyright © Materials Research Society 1988

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