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Ionotropically Gelled Bicontinuous Cubic Phase as a Matrix for Controlled Release

Published online by Cambridge University Press:  15 February 2011

S. Puvvada,
J. Naciri and
B. R. Ratna
S. Puvvada
Affiliation:
Also at the Dept. of Chemistry and Biochemistry, University of Colorado, Boulder, CO–80309
J. Naciri
Affiliation:
Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington, DC-20375
B. R. Ratna
Affiliation:
Also at the Dept. of Biochemistry, Georgetown University Medical Center, Washington, DC–20007
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Abstract

Release studies from a lipid-based matrix, known as the bicontinuous cubic phase, are presented. This matrix consists of nano-sized pores within which various proteins and drugs can be dispersed and subsequently released to the exterior. To control the release rate, the aqueous pores of the cubic phase were gelled using sodium alginate, a water soluble polysaccharide. Studies show that the release rate is significantly lowered upon gelation and the first order release profile exhibited by the ungelled cubic phase is converted to a zeroorder linear profile. Further, it has been shown that the release trends can be reversed by degelation. This opens up the possibility of releasing large quantities of the protein when required (drugs on demand concept) by degelling the gelled samples.

Information

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 331: Symposium T – Biomaterials for Drug and Cell Delivery , 1993, 217
Copyright
Copyright © Materials Research Society 1994

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