Hostname: page-component-7b7567c8c-7pwfn Total loading time: 0 Render date: 2026-11-13T12:55:25.027Z Has data issue: false hasContentIssue false
  • English
  • Français

Reaction and diffusion dynamics in a microfluidic format

Published online by Cambridge University Press:  15 March 2011

Dietrich Kohlheyer,
Rob G. H. Lammertink,
Stefan Schlautmann,
Geert A. J. Besselink,
Paul Vulto and
Richard B. M. Schasfoort
Dietrich Kohlheyer
Affiliation:
MESA+ Research Institute, Biochip Group, University of Twente P.O. Box 217 7500 AE Enschede, The Netherlands
Rob G. H. Lammertink
Affiliation:
MESA+ Research Institute, Biochip Group, University of Twente P.O. Box 217 7500 AE Enschede, The Netherlands
Stefan Schlautmann
Affiliation:
MESA+ Research Institute, Biochip Group, University of Twente P.O. Box 217 7500 AE Enschede, The Netherlands
Geert A. J. Besselink
Affiliation:
MESA+ Research Institute, Biochip Group, University of Twente P.O. Box 217 7500 AE Enschede, The Netherlands
Paul Vulto
Affiliation:
MESA+ Research Institute, Biochip Group, University of Twente P.O. Box 217 7500 AE Enschede, The Netherlands
Richard B. M. Schasfoort
Affiliation:
MESA+ Research Institute, Biochip Group, University of Twente P.O. Box 217 7500 AE Enschede, The Netherlands
Get access

Abstract

A novel microfluidic structure based on the electroosmotic guiding of reagent streams is presented that can be used as a fully adjustable diffusion based microreactor. The position and the width of two aqueous reactant streams entering a laminar-flow chamber can be controlled individually by changing the flow ratio of three parallel guiding streams containing buffer only. To control the intensity of product formation, the overlapping area between the diffusion regions of the two different reagent streams can be adjusted. This article describes the fabrication and experimental characterization of the device.

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

1. Tüdos, A.J., Besselink, G.A.J., Schasfoort, R.B.M., “Trends in miniaturized total analysis systems for point-of-care testing in clinical chemistry”, Lab on a Chip, 2001, 1, 83–95 Google Scholar
2. Haswell, Stephen J., Skelton, Victoria, “Chemical and biochemical microreactors”, Trends in analytical chemistry, 2000, vol.19, no. 6 Google Scholar
3. Brody, J.P., Yager, P., Goldstein, R.E., Austin, R.H., “Biotechnology at low Reynolds numbers”, Biophysical Journal, 1996, 71, 3430–3441 Google Scholar
4. Weigl, B.H., Yager, P., “Silicon-microfabricated diffusion-based optical chemical sensor”, Sensors and Actuators B, 1997, 38–39, 425–457 Google Scholar
5. Geert Besselink, A.J., Vulto, Paul, Lammertink, Rob G.H., Schlautmann, Stefan, Berg, Albert van der, Olthuis, Wouter, Engbers, Gerahard H.M. and Schasfoort, Richard B.M., “Electroosmotic guiding of sample flows in a laminar flow chamber”, Electrophoresis, submitted 02.2004 Google Scholar
6. Baroud, Charles N., Okkels, Fridolin et al. , “Reaction-diffusion dynamics: Confrontation between theory and experiment in a microfluidic reactor”, Physical Review E, 2003, 67 Google Scholar
7. Wensink, H., Elwenspoek, M.C., “Reduction of sidewall inclination and blast lag of powder blasted channels”, Sensors and Actuators A, 2002, 102, 157–164 Google Scholar
8. a, K. Yunus, Marks, C.B. et al. , “Hydrodynamic voltammetry in microreactors: multiphase flow”, Electrochemistry Communications”, 2002, 4, 579–583 Google Scholar