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Alpha-Crystallin Protein Quaternary Structure Assembly Model

Published online by Cambridge University Press:  15 February 2011

P. Licinio
P. Licinio*
Affiliation:
Departamento de Fisica, Universidade Federal de Minas Gerais - C.P. 702–30161 Belo Horizonte - MG - Brazil.
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Abstract

Eye-lens alpha-crystallins are very peculiar In the sense that they present polydispersity, a quality most often shared by man made polymers. Quaternary structure studies reveal that these proteins are assembled from about 50 subunits of two kinds. We developped a mixed aggregation model which renders, for alpha-crystallins, both size and polydispersity, in accordance with data in the litterature. The initial stoichiometry controls stability in the aggregation process and should be a very sensitive parameter to monitor in mixed aggregations.

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References

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