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Bone Tissue Scaffold Technologies Based on RP Adopted Droplet Assembly1

Published online by Cambridge University Press:  11 February 2011

Renji Zhang,
Yongnian Yan and
Feng Lin
Renji Zhang
Affiliation:
Dept. of Mechanical Engineering, Tsinghua University, Beijing 100084, P. R. China
Yongnian Yan
Affiliation:
Dept. of Mechanical Engineering, Tsinghua University, Beijing 100084, P. R. China
Feng Lin
Affiliation:
Dept. of Mechanical Engineering, Tsinghua University, Beijing 100084, P. R. China
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Abstract

Tissue engineering tries to grow replacement tissues to repair damaged bones. In this paper, the fabrication technology of Multi-nozzle Deposition Manufacturing (MDM) was adopted to fabricate scaffolds of a tissue engineered bone at low temperature. The composite of poly(L-lactic acid) and tri-calcium phosphate (TCP) was chosen to form bone tissue engineering scaffolds. The new computer aided manufacturing process can make porous PLLA/TCP scaffolds. A new surface processing technology of apatite coating on bone tissue engineered scaffolds was also adopted. This digital forming technology was based on rapid prototyping (RP), in which a digital droplets assembly technology was introduced. The MDM technology of 4 nozzles was developed based on the layer-by-layer manufacturing principle of Solid Freeform Fabrication (SFF) in our laboratory. The bone scaffolds made by the multi-nozzle deposition process in the MDM system have good biocompatibility and bone conductive properties as a molecular scaffold for bone morphogenic protein (BMP) in the implantation experiment of repairing segment defects in rabbits' and dogs' radiuses.

Information

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 758: Symposium LL – Rapid Prototyping Technologies , 2002, LL5.1
Copyright
Copyright © Materials Research Society 2003

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Footnotes

1

Supported by the Hi-Tech Research and Development Program of China, No. 715–009–0160.

References

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