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A CMOS Medium Density DNA Microarray with Electronic Readout

Published online by Cambridge University Press:  01 February 2011

Roland Thewes ,
Christian Paulus ,
Meinrad Schienle ,
Franz Hofmann ,
Alexander Frey ,
Petra Schindler-Bauer ,
Melanie Atzesberger ,
Birgit Holzapfl ,
Thomas Haneder  and
Hans-Christian Hanke
Roland Thewes
Affiliation:
Infineon Technologies AG, Corporate Research, D 81730 Munich, Germany
Christian Paulus
Affiliation:
Infineon Technologies AG, Corporate Research, D 81730 Munich, Germany
Meinrad Schienle
Affiliation:
Infineon Technologies AG, Corporate Research, D 81730 Munich, Germany
Franz Hofmann
Affiliation:
Infineon Technologies AG, Corporate Research, D 81730 Munich, Germany
Alexander Frey
Affiliation:
Infineon Technologies AG, Corporate Research, D 81730 Munich, Germany
Petra Schindler-Bauer
Affiliation:
Infineon Technologies AG, Corporate Research, D 81730 Munich, Germany
Melanie Atzesberger
Affiliation:
Infineon Technologies AG, Corporate Research, D 81730 Munich, Germany
Birgit Holzapfl
Affiliation:
Infineon Technologies AG, Corporate Research, D 81730 Munich, Germany
Thomas Haneder
Affiliation:
Infineon Technologies AG, Corporate Research, D 81730 Munich, Germany
Hans-Christian Hanke
Affiliation:
Infineon Technologies AG, Corporate Research, D 81730 Munich, Germany
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Abstract

A CMOS chip-based approach is reviewed for fully electronic DNA detection. The electrochemical sensor principle used, CMOS integration of the required transducer materials, chip architecture and circuit design issues are discussed, respectively. Electrochemical and biological results obtained on the basis of medium density microarray sensor CMOS chips with 16×8 sensor sites prove proper operation.

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