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Monolayers from Genetically Engineered Protein Pores

Published online by Cambridge University Press:  15 February 2011

Hagan Bayley
Hagan Bayley*
Affiliation:
Worcester Foundation for Experimental Biology, 222 Maple Avenue, Shrewsbury, MA 01545
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Abstract

A selection of microscopic pores is being made by genetic manipulation of a bacterial channel protein, α-hemolysin (α-HL). It will include: pores with different internal diameters, with differential selectivity for the passage of classes of molecules, and with different gating properties. The pores will be made into monolayers and incorporated into materials such as thin films to confer novel permeability properties upon them. Such products will have several technological applications, for example as molecular filters in sensors or as components of optically gated devices in electronics.

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