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Multivalent Biomimetic Glyconanoparticle Platforms as QCM Amplifiers for Lectin-carbohydrate Interactions

Published online by Cambridge University Press:  01 February 2011

Eugene Mahon,
Teodor Aastrup and
Mihail Barboiu
Eugene Mahon
Affiliation:
mahon@iemm.univ-montp2.fr, IEM, Montpellier, France
Teodor Aastrup
Affiliation:
teodor.aastrup@attana.com, ATTANA AB, Stockholm, Sweden
Mihail Barboiu
Affiliation:
mihai.barboiu@iemm.univ-montp2.fr, Institut Europeen des Membranes, Adaptive Supramolecular Nanosystems, Place Eugene Bataillon CC047, Montpellier, 34095, France
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Abstract

The Lectin-Carbohydrate interaction was investigated by combining the Quartz Crystal Microbalance-QCM technique with signal amplifying biomimetic nanoparticle-NP platforms. A library of glyconanoparticles was prepared and the avidity of these NPs for immobilised lectin layers was then evaluated by a QCM setup. Large responses were observed as a result of surface recognition by nanoparticles displaying the appropriate molecular functionality. Large affinity enhancements were also in evidence due to the biomimetic nature of the glyconanoparticle assemblies' carbohydrate presentation demonstrating evidence of the cluster glycoside effect.

Keywords

biomaterialbiomimetic (assembly)piezoresponse

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