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Nanoengineering of Immune Cell Function

Published online by Cambridge University Press:  31 January 2011

Keyue Shen,
Michael C Milone,
Michael L. Dustin and
Lance Cameron Kam
Keyue Shen
Affiliation:
ks2274@columbia.edu, Columbia University, Biomedical Engineering, New York, New York, United States
Michael C Milone
Affiliation:
milonem@uphs.upenn.edu, University of Pennsylvania School of Medicine, Pathology and Laboratory Medicine, Philadelphia, Pennsylvania, United States
Michael L. Dustin
Affiliation:
Michael.Dustin@med.nyu.edu, New York School of Medicine, Skirball Institute of Biomolecular Medicine, New York, New York, United States
Lance Cameron Kam
Affiliation:
lk2141@columbia.edu, Columbia University, Biomedical Engineering, New York, New York, United States
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Abstract

T lymphocytes are a key regulatory component of the adaptive immune system. Understanding how the micro- and nano-scale details of the extracellular environment influence T cell activation may have wide impact on the use of T cells for therapeutic purposes. In this article, we examine how the micro- and nano-scale presentation of ligands to cell surface receptors, including microscale organization and nanoscale mobility, influences the activation of T cells. We extend these studies to include the role of cell-generated forces, and the rigidity of the microenvironment, on T cell activation. These approaches enable delivery of defined signals to T cells, a step toward understanding the cell-cell communication in the immune system, and developing micro/nano- and material- engineered systems for tailoring immune responses for adoptive T cell therapies.

Keywords

biomaterialbiomedicalnanoscale

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