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Osteoblast Attachment on Biomaterials as a Function of Surface Charge

Published online by Cambridge University Press:  15 February 2011

M. Marcolongo,
N. J. Dinardo,
N. Hickok,
R. Tuan,
K. Pourezzaei,
R. Beard,
D. Brennan,
P. Heipp and
T. Phan
M. Marcolongo
Affiliation:
Departments of Materials Engineering Drexel University, Philadelphia, PA 19104
N. J. Dinardo
Affiliation:
Departments of Physics Drexel University, Philadelphia, PA 19104
N. Hickok
Affiliation:
Department of Orthopaedic Surgery Research, Thomas Jefferson University, Philadelphia, PA 19107
R. Tuan
Affiliation:
Department of Orthopaedic Surgery Research, Thomas Jefferson University, Philadelphia, PA 19107
K. Pourezzaei
Affiliation:
Departments of Materials Electrical Engineering Drexel University, Philadelphia, PA 19104
R. Beard
Affiliation:
Departments of Materials Electrical Engineering Drexel University, Philadelphia, PA 19104
D. Brennan
Affiliation:
Departments of Physics Drexel University, Philadelphia, PA 19104
P. Heipp
Affiliation:
Departments of Materials Biomedical Engineering Drexel University, Philadelphia, PA 19104
T. Phan
Affiliation:
Departments of Materials Chemical Engineering, Drexel University, Philadelphia, PA 19104
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Abstract

Bioactive materials such as calcium phosphate ceramics and bioactive glasses enhance bone tissue formation and then bond to bone tissue. In our work, we question what particular surface feature or features of bioactive materials are responsible for the bone tissue response. In this study we have uncoupled surface charge from surface chemistry, energy, and topography and have examined osteoblast adhesion to titanium surfaces of varying surface charge. We have shown that a negative surface charge promotes osteoblast adhesion by approximately 60% over a neutral surface and that conversely, a positive surface charge inhibits osteoblast adhesion by about 20%. Continued examination of surface characteristics that control cellular responses are warranted with the eventual goal of applying those desirable surface characteristics to any structural biomaterial for bone implant or tissue engineering applications.

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