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Patterned Adhesion of Cells

Published online by Cambridge University Press:  01 February 2011

Robert Lee Zimmerman,
Ismet Gurhan and
Daryush ILA
Robert Lee Zimmerman
Affiliation:
rlzimm@cim.aamu.edu, Alabama A&M University, Center for Irradiation of Materials, 3900 Meridian Street, Normal, AL, 35762, United States, 256 653 2134
Ismet Gurhan
Affiliation:
ismetgurhan@yahoo.com, Ege University, Faculty of Engineering, Izmir, N/A, Turkey
Daryush ILA
Affiliation:
ila@cim.aamu.edu, Alabama A&M University, Center for Irradiation of Materials, 3900 Meridian Street, Normal, AL, 35762, United States
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Abstract

It is well known that silver deposition avoids bacterial growth and inhibits the natural process of attachment of connective tissue to biocompatible materials in vivo. We have completed a five year investigation of the precise spatial control of cell growth on glassy polymeric carbon implanted with silver using ion beam techniques, and the persistence of the inhibitory effect on cell growth. Long term inhibition of cell growth on GPC is a desirable improvement on current cardiac implants and other biocompatible materials placed in the blood stream. We have used implanted silver ions near the surface of GPC to completely inhibit cell attachment and adhesion. Cells attach and strongly adhere to areas close to the silver implanted surfaces. Patterned ion implantation permits precise control of tissue growth on GPC and other biocompatible substrates. Cell growth limited to micrometric patterns on a substrate may be useful for in vitro studies of associated biological processes in an otherwise identical environment. The patterned inhibition of cell attachment persists for periods of time significant relative to typical implant lifetimes.

Keywords

biomaterialadhesioncellular (material form)

Information

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1020: Symposium GG – Ion-Beam-Based Nanofabrication , 2007, 1020-GG05-01
Copyright
Copyright © Materials Research Society 2007

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