Hostname: page-component-7b7567c8c-2n9c9 Total loading time: 0 Render date: 2026-11-14T16:50:22.162Z Has data issue: false hasContentIssue false
  • English
  • Français

Thermoresponsive Hydrogel Microvalve Based on Magnetic Nanoheaters for Microfluidics

Published online by Cambridge University Press:  27 April 2011

Santaneel Ghosh,
Arup Neogi,
Chao Yang,
Tong Cai,
Somesree GhoshMitra,
David Diercks and
Zhibing Hu
Santaneel Ghosh
Affiliation:
Physics and Engineering Physics, Southeast Missouri State University, One University Plaza, MS 6600, Cape Girardeau, MO, 63701
Arup Neogi
Affiliation:
University of North Texas, Denton, TX, 76203
Chao Yang
Affiliation:
University of North Texas, Denton, TX, 76203
Tong Cai
Affiliation:
University of North Texas, Denton, TX, 76203
Somesree GhoshMitra
Affiliation:
Texas Woman's University, Denton, TX, 76201
David Diercks
Affiliation:
University of North Texas, Denton, TX, 76203
Zhibing Hu
Affiliation:
University of North Texas, Denton, TX, 76203
Get access

Abstract

A novel magneto-active gel based nanomaterial system is presented as an externally tunable flow controller inside a microfluidic channel using the thermoresponsive property of the structure. Integration of ferromagnetic nanoparticles (Fe3O4) in the temperature sensitive polymer-poly (N-isopropylacrylamide) (PNIPAM) provides the swelling and de-swelling behavior of magnetic stimuli controlled micro-component by generating the heat due to the hysteresis loss of Fe3o4 under exposure in an alternating magnetic field. The shrinkage rates of the nanomaterial system at the bulk and micro scale are investigated. Size dependent shrinkage rate and actuation efficiency are ideal for various applications like magnetic micro/nano pump, magnetic field controlled drug delivery devices and magnetic switch applications.

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

REFERENCES

1. Kim, K. S., Park, J. K., “Magnetic force-based multiplexed immunoassay using superparamagnetic nanoparticles in microfluidic channel”, Lab on a Chip, 2005, 5, pp. 657–664.Google Scholar
2. Bashir, R., “BioMEMS: state-of-the-art in detection, opportunities and prospects”, Advanced Drug Delivery Reviews, 2004.Google Scholar
3. Peppas, A., Hilt, J., Khademhosseini, A., Langer, R., “Hydrogels in Biology and Medicine: From Molecular Principles to Bionanotechnology”, Advanced Materials, 2006, 18, pp. 1345–1360.Google Scholar
4. Lao, L. L., Ramanujan, R.V., “Magnetic and Hydrogel composite materials for hyperthermia applications”, Materials Science: Materials in Medicine, 2004, pp. 1061–1064 Google Scholar
5. Babincova, M., Leszczynska, D., Sourivong, P., Cicmanec, P., Babinec, P.,“Superparamagnetic gel as a novel material for electromagnetically induced hyperthermia”, Magnetism and Magnetic Materials, 2004, pp. 33–39 Google Scholar
6. Mitsumori, M., Hiraoka, M., Shibata, T., Okuno, Y., Nagata, Y., Nishimura, Y., Abe, M., Hasegawa, M., Nagae, H., Ebisawa, Y., “Targeted hyperthermia using dextran magnetic complex: A new treatment modality for liver tumors: Is postoperative chemotherapy effective for the prevention of recurrence after surgery for hepatocellular carcinoma?”, Hepato-Gastroentology, 1996, 43, pp. 1431–1437.Google Scholar
7. Kato, N., Oishi, A., “Enzyme reaction controlled by magnetic heating to the hysteresis loss of γ—Fe2O3 in thermoresponsive polymer gels immobilized β.galactose”, Takahashi, F., Materials Science and Engineering C 6, 1998, pp. 291–296.Google Scholar
8. Ghosh, S., Neogi, A., Cai, T., Hu, Z., “Magnetically controlled thermoresponsive hydrogel for microfluidics and biomemetics”, presented at the Materials Research Society Fall 2007 Meeting, Boston, MA, Nov 26-Dec 1.Google Scholar
9. GhoshMitra, S., Cai, T., Ghosh, S., Neogi, A., Cai, T., Hu, Z., Mills, N., “Microbial growth response to hydrogel encapsulated quantum dot nanospheres”, presented at the Materials Research Society Fall 2007 Meeting, Boston, MA, Nov 26-Dec 1.Google Scholar
10. Ma, M., Wu, Y., Zhou, J., Sun, Y., Zhang, Y., Gu, N., “Size dependence of specific power absorption of Fe3O4 particles in AC magnetic field”, Magnetism and Magnetic Materials, 2004, pp. 33–39 Google Scholar
11. Hu, Z.B., Chen, Y., Wang, C., Zheng, Y., Li, Y., “Polymer gels with engineered environmentally responsive surface patterns”, Nature 1998, 393, 149.Google Scholar
12. Hu, Z.B., Lu, X., Gao, J., Wang, C., “Polymer gel nanoparticle networks”, Advanced Materials, 2000, 12, No. 16, pp. 1173–1175.Google Scholar