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Plasmodium falciparum gametocytes: their longevity and infectivity

Published online by Cambridge University Press:  06 April 2009

M. E. Smalley and
R. E. Sinden
M. E. Smalley
Affiliation:
Medical Research Council Laboratories, Fajara, P.O. Box 273, Banjul, The Gambia, West Africa
R. E. Sinden
Affiliation:
Department of Zoology and Applied Entomology, Imperial College, London SW7 2EE
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Extract

The longevity and infectivity of isolated populations of Plasmodium falciparum gametocytes were studied. Following chloroquine treatment gametocyte numbers fell with a constant rate of loss over a period of 16–24days; the populations had a half-life of 2·4 days. The sex ratio stayed constant throughout at 4 female:1 male. The ability of the microgametocytes to exflagellate and the infectivity of the population to mosquitoes persisted for 3 weeks. Antibodies to the gametocytes were detected but not in every patient studied. It was concluded that the gametocytes of P. falciparum are both long-lived and show persistent infectivity to mosquitoes. They can stimulatae antibody production but the immune response appears to play no part in their elimination, which probably takes place in the spleen as a part of the normal process of removing old, damaged and malformed red cells.

Information

Type
Research Article
Information
Parasitology , Volume 74 , Issue 1 , February 1977, pp. 1 - 8
Copyright
Copyright © Cambridge University Press 1977

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References

Boyd, M. F. (1949). Malariology, Vol. 2. Philadelphia: W. B. Saunders.Google Scholar
Bray, R. S., McCrae, A. W. R. & Smalley, M. E. (1976). Lack of a circadian rhythm in the ability of the gametocytes of Plasmodium falciparum to infect Anopheles gambica. International Journal for Parasitology 6, 399–401.Google Scholar
Cohen, S., McGregor, I. A. & Carrington, S. (1961). Gamma globulin and acquired immunity to human malaris. Nature, London 192, 733–7.Google Scholar
Garnham, P. C. C. (1966). Malaria Parasites and Other Haemosporidia. Oxford: Blackwell Scientific Publications.Google Scholar
Hawking, F., Gammage, K. & Worms, M. J. (1972). The asexual and sexual circadian rhythums of Plasmodium vinckei chabaudi and of P. beryhei and of P. gallinaceum. Parasitology 65, 189–210.CrossRefGoogle Scholar
Hawking, F., Wilson, M.E. & Gammage, K. (1971). Evidence for cyclic development and short-lived maturity in the gametocytes of Plasmodium falciparum. Transactions of the Royal Society of Tropical Medicine and Hugiene 65, 549–59.CrossRefGoogle ScholarPubMed
Hawking, F., Wilson, M.E. & Gammage, K. (1968). 24- and 48-hour cycles of malaria parasites in the blood; their purpose, production and control. Transactions of the Royal Society of Tropical Medicine and Hygiene 62, 731–60.CrossRefGoogle ScholarPubMed
Hawking, F., Worms, M. J., Gammage, K. & Goddard, P. A. (1966). The biological purpose of the blood cycle of the malaria parasite Plasmodium cynomolgi. Lancet 2, 422–4.Google Scholar
Jeffery, G. M. & Eyles, D. E. (1955). Infectivity to mosquitoes of Plasmodium falciparum as related to gametocyte density and duration of infection. American Journal of Tropical Mediciene and Hygiene 4, 781–9.Google Scholar
Jeffery, G. M., Young, M. D. & Eyles, D. E. (1956). The treatment of Plasmodium falciparum infection with chloroquine, with a note on infectivity to mosquitoes of primaquine-and pyrimethamine-treated cases. American Journal of Hygiene 64, 1–11.Google Scholar
Kass, L., Willerson, D., Rieckmann, K. H. & Carson, P. E. (1971). Blastoid Transformation of lymphocytes in falciparum malaria. American Journal of Tropical Medicine and Hygiene 20, 195–8.CrossRefGoogle ScholarPubMed
Reickmann, K. H., McNamara, J. V., Kass, L. & Powell, R. D. (1969). Gametocytocidal and sporontocidal effects of primaquine upon two strains of Plasmodium falciparum. Military Medicine (special issue) 134, 802–19.CrossRefGoogle Scholar
Swanson-Beck, J., Logie, A. W. & McGregor, I. A. (1970). Antigenic changes during the life-cycle of Plasmodium falciparum. Experientia 26, 1365–6.Google Scholar
Voller, A. & Bray, R. S. (1962). Fluorescent antibody staining as a measure of malarial antibody. Proceedings of the Society for Experimental Biology and Medicine 110, 907–10.Google Scholar
Wintrobe, M. M. (1974). Clinical Haematology, chapter 8. Philadelphia: Lea and Febiger.Google Scholar