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Workshop no. 6. Structure, function and evolution of kinetoplast DNA

Published online by Cambridge University Press:  19 November 2018

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The kinetoplast DNA (kDNA) of kinetoplastidae was the first mitochondrial DNA (mtDNA) to be discovered, and with its unusual network structure, consisting of more than 104 catenated DNA circles, it is without equal in nature. Analysis of networks from various genera (reviewed by Borst & Hoeijmakers (1979a) and Englund (1980)) has shown that they always consist of two components: mini-circles and maxi-circles (see Table 1). The mini-circles are the major component and deterraine the size and sliape of networks. They vary in size between 1 and 3 kilo-base pairs (kb = 1000 base pairs (bp)), they are heterogeneous in sequence, their sequence evolves rapidly and their function is not yet known. The maxi-circles, on the other hand, are homogeneous in sequence, their sequence is conserved and they probably represent the counterpart of mtDNA in other organisms.

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Research Article
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Parasitology , Volume 82 , Issue 4 , July 1981, pp. 81 - 93
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Copyright © Cambridge University Press 1981

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