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Testing the flow-through capillary for the study of re-solvation processes in pharmaceutical compounds

Published online by Cambridge University Press:  23 June 2020

Jan RohlíčekOpen the ORCID record for Jan Rohlíček[Opens in a new window],
Vít Zvoníček,
Eliška Skořepová and
Miroslav Šoóš
Jan Rohlíček*
Affiliation:
Department of Structure Analysis, Institute of Physics ASCR, Prague, Czech Republic
Vít Zvoníček
Affiliation:
Department of Chemical Engineering, University of Chemistry and Technology, Prague, Czech Republic
Eliška Skořepová
Affiliation:
Department of Structure Analysis, Institute of Physics ASCR, Prague, Czech RepublicDepartment of Chemical Engineering, University of Chemistry and Technology, Prague, Czech Republic
Miroslav Šoóš
Affiliation:
Department of Chemical Engineering, University of Chemistry and Technology, Prague, Czech Republic
*
a)Author to whom correspondence should be addressed. Electronic mail: rohlicek@fzu.cz
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Abstract

This paper describes a new flow-through capillary sample holder that allows the in situ study of re-solvation processes. The holder can be aligned to the goniometer's center using two perpendicular micrometric tables that move in y and z directions. The re-solvation of two ibrutinib solvates of anisole and fluorobenzene was tested using the holder to show the practical application of this technique.

Keywords

flow-through capillaryholderX-ray diffractionre-solvationibrutinib

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Type
Technical Article
Information
Powder Diffraction , Volume 35 , Issue 3 , September 2020, pp. 160 - 165
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Copyright
Copyright © International Centre for Diffraction Data 2020

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