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X-ray powder diffraction analysis of ±-fenoprofen calcium dihydrate

Published online by Cambridge University Press:  05 March 2012

Ailette Aguila Tobien and
Peter Varlashkin
Ailette Aguila Tobien
Affiliation:
GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, North Carolina 27709
Peter Varlashkin*
Affiliation:
GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, North Carolina 27709
*
a)Author to whom correspondence should be addressed; electronic mail: Peter.G.Varlashkin@gsk.com
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Abstract

The current JCPDS powder pattern for the racemic compound fenoprofen calcium dihydrate (card No. 44-1790) is unindexed. Previously we reported the single crystal data, determined at −100 °C, for this material (Zhu et al., 2001). Using 2θ values obtained from a powder pattern spiked with internal standards, we indexed the room temperature powder pattern. The resulting unit cell values for the monoclinic P21/n cell are a=19.018 Å, b=7.738 Å, c=19.472 Å, β=91.66°.

Keywords

fenoprofen calciumpowder X-ray patternpowder X-ray diffraction

Information

Type
New Diffraction Data
Information
Powder Diffraction , Volume 17 , Issue 3 , September 2002, pp. 244 - 246
Copyright
Copyright © Cambridge University Press 2002

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References

Bernstein, J. and Zevin, L. (1993). JCPDS card 44-1790.Google Scholar
Florey, K., editor (1977). Analytical Profiles of Substances and Excipients (Academic, New York), Vol. 6, pp. 161–182.Google Scholar
Sathe, R.and Moore, S. (1995). “Dehydration and hydration kinetics, phase change, solubility and dissolution behavior of fenoprofen calcium,” Drug Dev. Ind. Pharm. DDIPD8 21, 1887–1894. ddi, DDIPD8 CrossRefGoogle Scholar
Zhu, H., Xu, J., Varlashkin, P., Long, S., and Kidd, C. (2001). “Dehydration, hydration behavior, and structural analysis of fenoprofen calcium,” J. Pharm. Sci. JPMSAE 90, 845–859. jmk, JPMSAE CrossRefGoogle ScholarPubMed