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X-ray powder diffraction data of lapatinib ditosylate monohydrate
Published online by Cambridge University Press: 29 February 2012
Abstract
The room temperature powder pattern of lapatinib ditosylate monohydrate (active ingredient in Tykerb used to treat refractory breast cancer) was indexed and the cell from the single crystal X-ray diffraction structure was refined using the experimental capillary data. Unit-cell parameters for the orthorhombic compound with space group Pbca refined from powder diffraction data are a=9.6850±0.0009 Å, b=29.364±0.003 Å, and c=30.733±0.003 Å, α=β=γ=90°, z=8, V=8740.1 Å3. Values of 2θ, d, I, and Miller indices are reported.
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- New Diffraction Data
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- Copyright © Cambridge University Press 2009
References
Boultif, A. (2005). “History of the dichotomy method for powder pattern indexing,” Powder Diffr. PODIE2 20, 284–287. 10.1154/1.2135307CrossRefGoogle Scholar
Boultif, A. and Louer, D. (2004). “Powder pattern indexing with the dichotomy method,” J. Appl. Crystallogr. JACGAR 37, 724–731. 10.1107/S0021889804014876CrossRefGoogle Scholar
Copley, R. “Single crystal X-ray structure” (private communication).Google Scholar
de Wolff, P. M. (1968). “A simplified criterion for the reliability of a powder pattern indexing,” J. Appl. Crystallogr. JACGAR 1, 108–113. 10.1107/S002188986800508XCrossRefGoogle Scholar
Johnston, S. R. D. and Leary, A. (2006). “Lapatinib: A novel EGFR/HER2 tyrosine kinase inhibitor for cancer,” Drugs Today (Barc) 42, 441–453. 10.1358/dot.2006.42.7.985637 CrossRefGoogle ScholarPubMed
Smith, G. S. and Snyder, R. L. (1979). “F(N): A criterion for rating powder diffraction patterns and evaluating the reliability of powder pattern indexing,” J. Appl. Crystallogr. JACGAR 12, 60–65. 10.1107/S002188987901178XCrossRefGoogle Scholar
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