Hostname: page-component-74656f9884-2dmjx Total loading time: 0 Render date: 2026-11-08T21:57:46.019Z Has data issue: false hasContentIssue false
  • English
  • Français

Working with clozapine

Published online by Cambridge University Press:  02 January 2018

Clive Adams  and
M. Adib Essali
M. Adib Essali
Affiliation:
Department of Psychiatry, Charing Cross Hospital, Fulham Palace Road, London W6 8RF
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the 'Save PDF' action button.

Clozapine is an atypical antipsychotic drug with relatively weak D2 and D1 blocking properties and strong 5HT and cholinergic blockade. Its potency as an antipsychotic drug is surprising considering the ratio of receptor blockade and it represents a true advance in treatment of schizophrenia. The efficacy of clozapine calls for revision of the seemingly over simplistic dopamine theory of schizophrenia. Now clozapine is available in the UK to consultant psychiatrists who register with the Clozaril Patient Monitoring Service (CPMS).

Information

Type
Articles
Information
Psychiatric Bulletin , Volume 15 , Issue 6 , June 1991 , pp. 336 - 338
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
Copyright © Royal College of Psychiatrists, 1991

References

Adams, C., Riccio, M., McCarthy, D., Barnes, T. R. E. & Hirsch, S. R. H. (1990) Agranulocytosis induced by clozapine with the early addition of trifluoperazine: a case report. International Clinical Psychopharmacology, 5, 287–291.CrossRefGoogle ScholarPubMed
Chouinard, G., Jones, B. D. & Annable, L. (1978) Neuroleptic induced supersensitivity psychosis. American Journal of Psychiatry, 135, 1409–1410.Google ScholarPubMed
Kane, J., Hongfeld, G., Singer, J. & Meltzer, H. (1988) Clozapine for treatment-resistant schizophrenia: a double blind comparison with chloropromazine. Archives of General Psychiatry, 45, 789–796.CrossRefGoogle Scholar
Meltzer, H. Y. (1989) The follow up of clozapine treated treatment-resistant schizophrenics at six months. Archives of General Psychiatry, 46, 672–675.CrossRefGoogle Scholar
Westermyer, J. F. & Harrow, M. (1990) Prognosis and natural course of schizophrenia. Current Opinion in Psychiatry, 3, 3–7.CrossRefGoogle Scholar
Submit a response

eLetters

No eLetters have been published for this article.