Hostname: page-component-7b7567c8c-mnklg Total loading time: 0 Render date: 2026-11-13T09:54:33.994Z Has data issue: false hasContentIssue false
  • English
  • Français

Aberrant interhemispheric alpha coherence on electroencephalography in schizophrenic patients during activation tasks

Published online by Cambridge University Press:  09 July 2009

S. L. Morrison-Stewart,
D. Velikonja,
W. C. Corning and
P. Williamson
S. L. Morrison-Stewart*
Affiliation:
Department of Research, London Psychiatric Hospital, Ontario, Canada
D. Velikonja
Affiliation:
Department of Research, London Psychiatric Hospital, Ontario, Canada
W. C. Corning
Affiliation:
Department of Research, London Psychiatric Hospital, Ontario, Canada
P. Williamson
Affiliation:
Department of Research, London Psychiatric Hospital, Ontario, Canada
*
1Address for correspondence: Dr Sandra Morrison-Stewart, Department of Psychology, North Bay Psychiatric Hospital, Box 3010, North Bay, Ontario, Canada P1B 8L1.
Get accessRights & Permissions [Opens in a new window]

Synopsis

Thirty schizophrenic patients (20 medicated, 10 off medication) were compared with 30 normal controls subjects matched for age, sex, handedness and intelligence. During the performance of a frontal activation task, normal subjects showed increased interhemispheric coherence between anterior brain regions. Schizophrenic patients did not show the same amount of bilateral anterior activation. During the performance of right hemisphere cognitive activation tasks, normal subjects and medicated schizophrenic patients showed significantly reduced bilateral interhemispheric coherence patterns, while the drug-free schizophrenic patients showed a trend towards this same pattern. It is suggested that these findings provide additional evidence for an aberrant functional organization of the brain in schizophrenia.

Information

Type
Original Articles
Information
Psychological Medicine , Volume 26 , Issue 3 , May 1996, pp. 605 - 612
Copyright
Copyright © Cambridge University Press 1996

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

REFERENCES

Beaumont, J., Mayes, A. & Rugg, M. (1978). Asymmetry in EEG alpha coherence and power: effects of task and sex. Electroencephalography and Clinical Neurophysiology 45, 393–401.CrossRefGoogle ScholarPubMed
Bohdyreva, G. & Zhavoronkova, L. (1991). Interhemispheric asymmetry of EEG coherence as a reflection of different functional states of the human brain. Biomedical Science 2, 266–270.Google Scholar
Cooley, J. & Tukey, J. (1965). An algorithm for the machine calculation of complex Fourier series. Mathematics of Computation 19, 297–301.CrossRefGoogle Scholar
Fein, G., Raz, J., Brown, F. & Merrin, F. (1988). Common reference coherence data are confounded by power and phase effects. Electroencephalography and Clinical Neurophysiology 69, 581–584.CrossRefGoogle ScholarPubMed
Flor-Henry, P., Koles, Z. J., Howarth, B. G. & Burton, L. (1979). Neurophysiological studies of schizophrenia, mania and depression. In Hemispheric Asymmetries of Function in Psychopathology (ed. Gruzelier, J. and Flor-Henry, P.), pp. 189–222. Elsevier: Amsterdam.Google Scholar
Hoffman, R., Buchsbaum, M., Escobar, M., Makuch, R., Nuechterlein, K. & Guich, S. (1991). EEG coherence of prefrontal areas in normal and schizophrenic males during perceptual activation. Journal of Neuropsychiatry and Clinical Neurosciences 3, 169–175.Google ScholarPubMed
Jasper, H. (1958). The ten–twenty system of the International Federation. Electroencephalography and Clinical Neurophysiology 10, 371–375.Google Scholar
Kuda, B., Ralph, M., Buchsbaum, M. S. & Escobar, M. D. (1991). EEG coherence of prefrontal areas in normal and schizophrenic males during perceptual activation. Journal of Neuropsychiatry and Clinical Neurosciences 3, 169–175.Google Scholar
Lezak, M. (1983). Neuropsychological Assessment. Oxford University Press: New York.Google Scholar
Livanov, M., Gabrilova, N. & Aslanov, A. (1964). Intercorrelations between different cortical regions of human brain during mental activity. Neuropsychologia 2, 281–289.CrossRefGoogle Scholar
Michelogiannis, S., Paritsis, N. & Trikas, P. (1991). EEG coherence during hemispheric activation in schizophrenics. European Archives of Psychiatry and Clinical Neuroscience 241, 31–34.CrossRefGoogle ScholarPubMed
Morrison-Stewart, S. L., Williamson, P. C., Corning, W. C., Kutcher, S. P. & Merskey, H. (1991). Coherence on electroencephalography and aberrant functional organisation of the brain in schizophrenic patients during activation tasks. British Journal of Psychiatry 159, 636–644.CrossRefGoogle ScholarPubMed
Nagase, Y., Okubo, Y., Matsuura, M., Kojima, T. & Toru, M. (1992). EEG coherence in unmedicated schizophrenic patients: topographical study of predominantly never medicated cases. Biological Psychiatry 32, 1028–1034.CrossRefGoogle ScholarPubMed
Pockberger, H., Thau, K. & Lovrek, A. (1989). Coherence mapping reveals differences in the EEG between psychiatric patients and healthy persons. In Topographic Brain Mapping of EEG and Evoked Potentials (ed. Maurer, K.), pp. 451–457. Springer-Verlag: Berlin.CrossRefGoogle Scholar
Rappelsberger, P. & Petsche, H. (1988). Probability mapping: power and coherence analyses of cognitive processes. Brain Topography 1, 46–53.CrossRefGoogle ScholarPubMed
Seidman, L. (1983). Schizophrenia and brain dysfunction: an integration of recent neurodiagnostic findings. Psychological Bulletin 94, 195–238.CrossRefGoogle ScholarPubMed
Shaw, J. C., Colter, N. & Resek, G. (1983). EEG coherence, lateral preference and schizophrenia. Psychological Medicine 13, 299–306.CrossRefGoogle ScholarPubMed
Springer, S. & Deutsch, G. (1981). Left Brain, Right Brain. W. H. Freeman: San Francisco.Google Scholar
SPSS/PC (1990). Base Manual. SPSS Inc.: Chicago.Google Scholar
Stuss, D. & Benson, D. (1986). The Frontal Lobes. Raven Press: New York.Google Scholar
Szechtman, H., Nahmias, C., Garnett, S., Firnau, G., Brown, G., Kaplan, R. & Cleghorn, J. (1988). Effects of neuroleptics on altered cerebral glucose metabolism in schizophrenia. Archives of General Psychiatry 45, 523–532.CrossRefGoogle ScholarPubMed
Thatcher, R. W., Krause, P. J. & Hrybyk, M. (1986). Corticocortical associations and EEG coherence: A two compartmental model. Electroencephalography and Clinical Neurophysiology 64, 123–143.CrossRefGoogle ScholarPubMed
Widen, L., Blomquist, G., Greitz, T., Bergstrom, M., Ehrin, E., Ericson, K., Eriksson, L., Ingvar, D., Johanssan, L., Nilsson, J., Store-Elander, S., Sedvall, G., Wiesel, F. & Wiik, G. (1983). PET studies of glucose metabolism in patients with schizophrenia. American Journal of Neuroradiology 4, 550–552.Google ScholarPubMed