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Memory functions and prophylactic treatment with lithium

Published online by Cambridge University Press:  09 July 2009

L. Smigan and
C. Perris
L. Smigan*
Affiliation:
Department of Psychiatry, Umeå University, Umeå Sweden
C. Perris
Affiliation:
Department of Psychiatry, Umeå University, Umeå Sweden
*
1Address for correspondence: Dr Ludovit smigan, Department of Psychiatry, Umeå University, 901 85 Umeå, Sweden.
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Synopsis

Memory functions were examined in a group of 53 patients with affective disorders before commencing prophylactic lithium therapy and then after 4 and 12 months of lithium treatment. The memory tests administered were the 30 Figure Test, the 30 Word-Pair Test, the 30 Person-Data Test (these tests are included in the Cronhoim–Molander test battery) and the 30 Face Test. Three scores were obtained: immediate memory score, delayed memory score and forgetting score. There were no statistical significant differences between these scores before lithium therapy or after 4 and 12 months, except for immediate and delayed memory on the Person-Data Test and the 30 Face Test which showed an increased score of memory functions. The results of this study support the view that long-term lithium treatment with serum levels of about 0·6 mmol/1 does not induce memory disturbances.

Information

Type
Research Article
Information
Psychological Medicine , Volume 13 , Issue 3 , August 1983, pp. 529 - 536
Copyright
Copyright © Cambridge University Press 1983

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References

Aminoff, M. J., Marshall, J., Smith, E. & Wyke, M. (1974). Cognitive function in patients on lithium therapy. British Journal of Psychiatry 125, 109–110.CrossRefGoogle ScholarPubMed
Åsberg, M., Perris, C., Schalling, D. & Sedvall, G. (1978). The CPRS-development and application of a psychiatric rating scale. Acta Psychiatrica Scandinavica Suppl. 271.CrossRefGoogle Scholar
Bajor, G. F. (1977). Memory loss with lithium. American Journal of Psychiatry 134, 588.Google ScholarPubMed
Benowitz, L. I. & Sperry, R. W. (1973). Amnestic effects of lithium chloride in chicks. Experiment. Neurology 40, 540–546.Google Scholar
Brockington, I. & Leff, J. (1979). Schizoaffective psychoses: definition and incidence. Psychological Medicine 9, 91–99.CrossRefGoogle ScholarPubMed
Bucht, G., von Knorring, L., Smigan, L. & Wahlin, A. (1981). Control of lithium treatment — experiences from a lithium clinic. Nordisk Psykiatrisk Tidskrift 35, 160–165.CrossRefGoogle Scholar
Christodoulou, G. N., Siafakas, A. & Rineiris, P. M. (1977). Side-effects of lithium. Acta Psychiatrica Belgica 77, 260–266.Google ScholarPubMed
Christodoulou, G. N.Kokkevi, A., Lykouras, E. P., Stefanis, C. N. & Papadimitriou, G. N. (1981). Effects of lithium on memory. American Journal of Psychiatry 138, 847–848.Google ScholarPubMed
Coppen, A., Bailey, J. & Rao, R. (1978). Lithium on memory impaiment. Lancet i, 448.CrossRefGoogle Scholar
Cronholm, B. & Molander, L. (1957). Memory disturbances after electroconvulsive therapy. Acta Psychiatrica Scandinavica 31, 280–306.CrossRefGoogle Scholar
Cronholm, B. & Ottosson, J. O. (1961). Memory functions in endogenous depression. Archives of General Psychiatry 5, 193–199.CrossRefGoogle ScholarPubMed
Cronholm, B. & Ottosson, J. O. (1963). Reliability and validity of a memory test battery. Acta Psychiatrica Scandinavica 39, 218–234.CrossRefGoogle ScholarPubMed
Cronholm, B. & Schalling, O. (1963). Intellectual deterioration after focal brain injury – a test validation study. Archives of Surgery (Chicago) 86, 670–687.CrossRefGoogle ScholarPubMed
Cronholm, B. & Schalling, O. (1973). A study of memory in the aged. In Memory and Transfer of Information (ed. Zippel, H. P.), pp. 23–42. Plenum Press: New York.CrossRefGoogle Scholar
Cronholm, B., Eriksson, I. & Lindgren, S. A. (1961). Memory and concentration performances after protracted occupational exposure to carbon monoxide. Acta Psychiatrica Scandinavica 37, 127–142.CrossRefGoogle Scholar
Cronholm, B., Ottosson, J. O. & Schalling, D. (1970). The memory variables learning and retention in relation to intelligence and age in adults. Acta Psychialrica Scandinavica 46, Suppl. 219, 50–58.CrossRefGoogle Scholar
d'Elia, G. (1970). Unilateral electroconvulsive therapy. Acta Psychiatrica Scandinavica Suppl. 215.Google Scholar
d'Elia, G., Lehmann, J. & Raotma, H. (1978). Influence of tryptophan on memory functions in depressive patients treated with unilateral ECT. Acta Psychiarrica Scandinavica 57, 259–268.CrossRefGoogle ScholarPubMed
Friedman, M. J., Culver, C. M. & Ferrel, R. B. (1977). On the safety of long-term treatment with lithium. American Journal of Psychiatry 134, 1123–1126.Google ScholarPubMed
Johnson, F. N. (1976). The effect of lithium chloride on one-trial passive avoidance learning in rats. British Journal of Psychiatry 56, 87–91.Google ScholarPubMed
Johnson, F. N. & Barker, G. J. (1972). Effects of lithium chloride on learned responses. Diseases of the Nervous System 33, 664–666.Google ScholarPubMed
Judd, L. L., Hubbard, B., Janowsky, D. S., Huey, L. Y. & Hewell, P. A. (1977 a). The effect of lithium carbonate on affect, mood and personality of normal subjects. Archives of General Psychiatry 34, 346–351.CrossRefGoogle ScholarPubMed
Judd, L. L., Hubbard, B., Janowsky, D. S., Huey, L. Y. & Takahashi, K. I. (1977 b). The effect of lithium carbonate on the cognitive functions of normal subjects. Archives of General Psychiatry 34, 355–357.CrossRefGoogle ScholarPubMed
Kropf, D. & Müller-Oerlinghausen, B. (1979). Changes in learning, memory and mood during lithium treatment: approach to a research strategy. Acta Psychiatrica Scandinavica 59, 97–124.CrossRefGoogle ScholarPubMed
Kusumo, K. S. & Vaughan, M. (1977). Effects of lithium salts on memory. British Journal of Psychiatry 131, 451–457.CrossRefGoogle ScholarPubMed
Laurell, B. (1970). Flurothyl convulsive therapy. Acta Psychiatrica Scandinavica Suppl. 213.Google Scholar
Lund, Y., Nissen, M. & Rafaelsen, O. J. (1982). Long-term lithium treatment and psychological functions. Acta Psychiatrica Scandinavica 65. 233–244.CrossRefGoogle ScholarPubMed
Nie, N. H., Hull, C. H., Jenkins, J. G., Steinbrenner, K. & Bents, D. H. (1975). Statistical Package for the Social Sciences (second edn). McGraw-Hill: New York.Google Scholar
Ottosson, J. O. (1960). Experimental studies of memory and impairment after electroconvulsive therapy. Acta Psychiatrica Scandinavica Suppl. 145.CrossRefGoogle Scholar
Perris, C. (1966). A study of bipolar (manic-depressive) and unipolar recurrent psychoses. Acta Psychiatrica Scandinavica Suppl. 194.Google Scholar
Perris, C. & Brockington, I. (1981). Cycloid psychoses and their relation to the major psychoses. In Biological Psychiatry (ed. Perris, C., Struwe, G. and Jansson, B.), pp. 447–450. Elsevier/North HollandBiomedical Press.Google Scholar
Perris, C. & Smigan, L. (1980). Lithium and the kidney: our present knowledge and some guidelines for the future. Rivista di Psichiatria 15, 11–20.Google Scholar
Preodor, D., Wolpert, G. Y. & Ostrow, D. (1977). Memory loss with lithium treatment. American Journal of Psychiatry 134, 1047–1048.CrossRefGoogle ScholarPubMed
Rapp, M. S. & Thomas, M. R. (1979). Lithium and memory loss. Canadian Journal of Psychiatry 24, 700–701.CrossRefGoogle ScholarPubMed
Reus, V. I., Targum, S. D. & Weingartner, W. (1979). Effect of lithium carbonate on memory processes of bipolar affectively ill patients. Psychopharmacology 63, 39–42.CrossRefGoogle ScholarPubMed
Roussinov, K. S. & Yonkow, D. (1975). Comparative studies on the effect of lithium and haloperidol on learning and memory. Acta Physiologica et Pharmacologica Bulgarica 3(4), 51–57.Google ScholarPubMed
Schou, M. (1968). Lithium in psychiatric therapy and prophylaxis. Journal of Psychiatric Research 6, 67–95.CrossRefGoogle ScholarPubMed
Squire, L. R., Judd, L. L., Janowsky, D. S. & Huey, L. Y. (1980). Effects of lithium carbonate on memory and other cognitive functions. American Journal of Psychiatry 137, 1042–1046.Google ScholarPubMed
Telford, R. & Worrall, E. (1978). Cognitive functions in manicdepressives: effects of lithium and physiostigmine. British Journal of Psychiatry 133, 424–428.CrossRefGoogle Scholar
Zerbi, F., Glemente, G., Bezzi, G. & Tosca, P. (1981). Memory performances in depressed patients during prophylactic treatment with lithium salt. Bibliotheca Psychiatrica 161, 190–196.Google Scholar