Hostname: page-component-7b7567c8c-7pwfn Total loading time: 0 Render date: 2026-11-12T10:58:10.349Z Has data issue: false hasContentIssue false
  • English
  • Français

Thyroid dysfunction in institutionalised Down's syndrome adults

Published online by Cambridge University Press:  09 July 2009

H. G. Kinnell,
N. Gibbs,
J. D. Teale and
J. Smith
H. G. Kinnell*
Affiliation:
Botleys Park Hospital, Chertsey, Royal Surrey County Hospital, Guildford, St. Luke's Hospital, Guildford and May Day Hospital, Croydon
N. Gibbs
Affiliation:
Botleys Park Hospital, Chertsey, Royal Surrey County Hospital, Guildford, St. Luke's Hospital, Guildford and May Day Hospital, Croydon
J. D. Teale
Affiliation:
Botleys Park Hospital, Chertsey, Royal Surrey County Hospital, Guildford, St. Luke's Hospital, Guildford and May Day Hospital, Croydon
J. Smith
Affiliation:
Botleys Park Hospital, Chertsey, Royal Surrey County Hospital, Guildford, St. Luke's Hospital, Guildford and May Day Hospital, Croydon
*
1Address for correspondence: Dr H. G. Kinnell, Consultant Psychiatrist, Botleys Park Hospital, Guildford Road, Chertsey, Surrey KTI6 OQA.
Get accessRights & Permissions [Opens in a new window]

Synopsis

This study of 111 institutionalised Down's syndrome subjects and 74 controls found a relatively low risk of hypothyroidism in both groups compared with certain other studies of Down's subjects, which found very high rates of thyroid hypofunction. However, the Down's syndrome group had a significantly raised risk of hypothyroidism (9%), hyperthyroidism (1·8%) and the presence of thyroid microsomal antibodies (29%) compared with the controls and with laboratory reference data. It is recommended that thyroid function testing should be routine in older Down's syndrome subjects, with special attention being given to the clinical status of those with microsomal antibodies present.

Information

Type
Research Article
Information
Psychological Medicine , Volume 17 , Issue 2 , May 1987, pp. 387 - 392
Copyright
Copyright © Cambridge University Press 1987

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

Aarskog, D. (1969). Autoimmune thyroid disease in children with mongolism. Archives of Diseases of Childhood 44, 445–460.Google Scholar
Baxter, R. G., Martin, F. I. B., Heyma, P., Myles, K. & Ryan, L. (1975). Down's syndrome and thyroid function in adults. Lancet ii, 794–796.Google Scholar
Bellack, S. & Albaum, J. (1957). The thyroid function in mongoloids as determined by the measurement of protein bound iodine. American Journal of Mental Deficiency 62, 275.Google Scholar
Benda, C. E. (1960). The Child with Mongolism. p. 110. Grune & Stratton; New York.Google Scholar
Benda, C. E. (1953). Research in congenital acromicria (Mongolism) and its treatment. Quarterly Review of Pediatrics 8, 79–84.Google Scholar
Burgio, G. R., Sevari, F., Rossani, R. & Vaccaro, R. (1965). Autoantibodies in Down's syndrome. Lancet 1, 166–167.CrossRefGoogle Scholar
Cohen, K. L. & Swigar, M. E. (1979). Thyroid function screening in psychiatric patients. Journal of American Medical Association 242, 254–259.Google Scholar
Diggle, J. H. & Weetch, R. S. (1958). Thyrotoxicosis in a mongol. Proceedings of the Royal Society of Medicine 51, 293–294.Google Scholar
Esen, H. & Mautner, K. (1957) Hypo- and hyper-thyroidism in mongolism. Archives of Pediatrics 74, 291–302.Google Scholar
Fialkow, P. J., Uchilda, P. A., Hecht, F. & Matulsky, A. H. (1965) Increased frequency of thyroid antibodies in mothers of patients with Down's syndrome. Lancet ii, 868–870.Google Scholar
Fort, P., Lifshitz, F., Bellisario, R., Davis, J., Lanes, R., Pugliese, M., Richman, R., Post, E. M. & David, R. (1984). Abnormalities of thyroid function in infants with Down's syndrome. The Journal of Pediatrics 104, 545–549.CrossRefGoogle Scholar
Friedman, A. (1955). Radioactive uptake in children with mongolism. Pediatrics 16, 55–65.Google Scholar
Hughes, V. C., Cameron, J., Goonetilleke, A. S. R. (1982). The prevalence of thyroid dysfunction in mentally handicapped inpatients. Journal of Mental Deficiency Research 26, 115–120.Google Scholar
Johnson, J. E. & Cook, A. R. (1962). Hyperthyroidism in patients with mongolism. Journal of Clinical Endocrinology 22, 665–668.Google Scholar
Kay, C. J. & Esselborn, V. M. (1963) Hyperthyroidism and mongolism. American Journal of Diseases of Childhood 106, 411–414.Google Scholar
Korsager, S., Chatham, E. M. & Ostergaard Kristensen, N. P. (1978) Thyroid function tests in adults with Down's syndrome. Acta Endocrinologica 88, 48–54.Google Scholar
Leader, , Lancet (1986) i, 251–252.Google Scholar
Lobo, K. E. De H., Khan, M. & Tew, J. (1980). Community study of hypothyroidism in Down's syndrome. British Medical Journal 280, 1253.CrossRefGoogle Scholar
Marks, J. F., Windmiller, H., Freeman, B. & Peake, C. (1965) Thyroid function in mongoloid children. American Journal of Diseases of Children 110, 505–506.Google Scholar
McGirr, E. M. & Murray, I. P. C. (1956) Thyrotoxicosis in a mongol. Journal of Clinical Endocrinology 16, 160.Google Scholar
Mellon, J. P., Pay, B. Y. & Green, D. M. (1963). Mongolism and thyroid autoantibodies. Journal of Mental Deficiency Research 7, 31–37.Google Scholar
Monteiro, E., Galvao-Teles, A., Santos, M. L., Mourao, L., Correia, M. J., Tuna, J., & Lopo Ribeiro, C. (1986). Antithyroid antibodies as an early marker for thyroid disease induced by amiodarone. British Medical Journal 292, 227–230.Google Scholar
Murdoch, J. C., Ratcliffe, W. A., McLarty, D. G., Redger, J. C. & Ratcliffe, J. C. (1977). Thyroid function in adults with Down's syndrome. Journal of Clinical Endocrinology 44, 453–458.Google Scholar
Pearse, H. J., Reiss, M. & Suwalski, R. T. (1963). Thyroid function in patients with mongolism. Journal of Clinical Endocrinology 23, 311–312.Google Scholar
Piffanelli, A., Dallapiccola, B., Masala, C., Grandonico, F. & Brocchi, A. (1974) Studio dellia funzionalita tiroidea nella sindrome di Down. Progresso Medico Romo 30, 130–135.Google Scholar
Piffanelli, A., Dallapiccola, B. & Chielmi, S. (1976) Down's syndrome and thyroid function, Lancet i, 362–364.Google Scholar
Pueschel, S. M., & Pezzullo, J. C. (1985) Thyroid dysfunction in Down's syndrome. American Journal of Diseases of Children 139, 636–639.Google Scholar
Samuel, A. M., Krishna Morthy, D. S., Kadival, G. V., Patel, Z. M., Mehta, M. N., Ganatra, R. D. & Ambani, L. M. (1981). Thyroid function studies in young Down's syndrome. Indian Journal of Medical Research 73, 223–227.Google Scholar
Sare, Z., Ruvalcaba, R. H. A. & Kelley, V. C. (1978). Prevalence of thyroid disorders in Down's syndrome. Clinical Genetics 14,154–158.Google Scholar
Saxena, M. M. & Pryles, C. V. (1965). Thyroid function in mongolism. Journal of Pediatrics 67, 363–370.Google Scholar
Simon, A., Ludwig, C., Gofman, J. W. & Cook, G. H. (1954). Metabolic studies in mongolism, serum protein bound iodine, cholesterol and lipoprotein. American Journal of Psychiatry 111, 139–145.CrossRefGoogle Scholar
Sylvester, P. (1973) Autoimmune thyroiditis in mental handicap. Journal of Mental Deficiency Research 17, 18–23.Google Scholar
Tunbridge, W. M. G., Brewis, M., French, J. M., Appleton, D., Bird, T., Clark, F., Evered, D. C., Grimley Evans, J., Hall, R., Smith, P., Stephenson, J. & Young, E. (1981). Natural history of autoimmune thyroiditis. British Medical Journal 282, 258–262.Google Scholar
Vanhaelst, L., Hayes, F., Bonnyns, M. & Basteme, P. A. J. (1970). Thyroid autoimmune disease and thyroid function in families of subjects with Down's syndrome. Journal of Clinical Endocrinology 30, 792–797.Google Scholar