Hostname: page-component-7b7567c8c-7pwfn Total loading time: 0 Render date: 2026-11-15T18:49:23.161Z Has data issue: false hasContentIssue false
  • English
  • Français

Tribulin in post-traumatic stress disorder

Published online by Cambridge University Press:  09 July 2009

J. Davidson,
Vivette Glover,
Angela Clow,
H. Kudler,
K. Meador and
M. Sandler
J. Davidson
Affiliation:
Department of Psychiatry, Duke University Medical Center and Mental Hygiene Clinic, Veterans Administration Medical Center, Durham, North Carolina, USA; Department of Chemical Pathology, Queen Charlotte's Hospital, Goldhawk Road, London
Vivette Glover
Affiliation:
Department of Psychiatry, Duke University Medical Center and Mental Hygiene Clinic, Veterans Administration Medical Center, Durham, North Carolina, USA; Department of Chemical Pathology, Queen Charlotte's Hospital, Goldhawk Road, London
Angela Clow
Affiliation:
Department of Psychiatry, Duke University Medical Center and Mental Hygiene Clinic, Veterans Administration Medical Center, Durham, North Carolina, USA; Department of Chemical Pathology, Queen Charlotte's Hospital, Goldhawk Road, London
H. Kudler
Affiliation:
Department of Psychiatry, Duke University Medical Center and Mental Hygiene Clinic, Veterans Administration Medical Center, Durham, North Carolina, USA; Department of Chemical Pathology, Queen Charlotte's Hospital, Goldhawk Road, London
K. Meador
Affiliation:
Department of Psychiatry, Duke University Medical Center and Mental Hygiene Clinic, Veterans Administration Medical Center, Durham, North Carolina, USA; Department of Chemical Pathology, Queen Charlotte's Hospital, Goldhawk Road, London
M. Sandler*
Affiliation:
Department of Psychiatry, Duke University Medical Center and Mental Hygiene Clinic, Veterans Administration Medical Center, Durham, North Carolina, USA; Department of Chemical Pathology, Queen Charlotte's Hospital, Goldhawk Road, London
*
1 Address for correspondence: Professor M. Sandler, Department of Chemical Pathology, Queen Charlotte's Hospital, Goldhawk Road, London W6 0XG.
Get accessRights & Permissions [Opens in a new window]

Synopsis

Tribulin (endogenous monoamine oxidase inhibitor/benzodiazepine receptor binding inhibitor) output was measured in the urine of 18 patients with post-traumatic stress disorder (PTSD) and 13 controls. The level of the two inhibitory activities was highly significantly correlated in the group as a whole. There was no difference between output of either inhibitor in patients and controls. However, when the PTSD group was subdivided according to various psychometric ratings, a pattern of output did emerge. Levels of both inhibitory activities were higher in agitated compared with non-agitated subjects, and lower in extroverts compared with introverts. This finding supports the view that tribulin output is raised in conditions of greater arousal.

Information

Type
Research Article
Information
Psychological Medicine , Volume 18 , Issue 4 , November 1988, pp. 833 - 836
Copyright
Copyright © Cambridge University Press 1988

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

Armando, I., Barontini, M., Levin, G., Simsolo, R., Glover, V. & Sandler, M. (1984). Exercise increases endogenous urinary monoamine oxidase – benzodiazepine receptor ligand inhibitory activity in normal children. Journal of the Autonomic Nervous System 11,95–100.CrossRefGoogle ScholarPubMed
Armando, I., Glover, V. & Sandler, M. (1986). Distribution of endogenous benzodiazepine receptor ligand monoamine oxidase inhibitory activity (tribulin) in tissues. Life Sciences 38, 2063–2067.CrossRefGoogle ScholarPubMed
Bhattacharya, S. K., Glover, V., Sandler, M, Clow, A., Topham, A., Bernadt, M. & Murray, E. (1982). Raised endogenous monoamine oxidase inhibitor output in post-withdrawal alcoholics: effects of L-dopa and ethanol. Biological Psychiatry 17, 829–836.Google Scholar
Buchsbaum, M. S., Coursey, R. D. & Murphy, D. L. (1976). The biochemical high risk paradigm: behavioral and familial correlates of low platelet monoamine oxidase activity. Science 194, 339–341.CrossRefGoogle ScholarPubMed
Clow, A., Glover, V., Armando, I. & Sandler, M. (1983). New endogenous benzodiazepine receptor ligand in human urine: identity with endogenous monoamine oxidase inhibitor? Life Sciences 33 735–741.CrossRefGoogle ScholarPubMed
Clow, A., Glover, V., Sandler, M. & Tiller, J. (1988 a). Increased urinary tribulin output in generalised anxiety disorder. Psychopharmacology 95, 378–380.CrossRefGoogle ScholarPubMed
Clow, A., Glover, V., Weg, M. W., Walker, P L., Sheehan, D. V., Carr, D. B. & Sandler, M. (1988 b). Urinary catecholamine metabolite and tribulin output during lactate infusion. British Journal of Psychiatry 152, 122–126.CrossRefGoogle ScholarPubMed
Diagnostic and Statistical Manual of Mental Disorders 3rd ed. (1980). American Psychiatric Association: Washington DC.Google Scholar
Elsworth, J. D.Dewar, D., Glover, V., Goodwin, B., Clow, A. & Sandler, M. (1986). Purification and characterization of tribulin, an endogenous inhibitor of monoamine oxidase and of benzodiazepine receptor binding. Journal of Neural Transmission 67, 45–56.CrossRefGoogle ScholarPubMed
Endicott, J. & Spitzer, R. L. (1978). A diagnostic interview: the Schedule for Affective Disorders and Schizophrenia. Archives of General Psychiatry 35, 837–844.CrossRefGoogle ScholarPubMed
Eysenck, H. J. & Eynsenck, S. B. G. (1975). Manual of the Eysenck Personality Questionnaire (Junior and Adult). Hodder and Stoughton: London.Google Scholar
Glover, V., Bhattacharya, S. K., Sandler, M. & File, S. E. (1981). Benzodiazepines reduce stress-augmented increase in rat urine monoamine oxidase inhibitor. Nature 292, 347–349.CrossRefGoogle ScholarPubMed
Glover, V., Reveley, M. A. & Sandler, M. (1980). Monoamine oxidase inhibitor in human urine. Biochemical Pharmacology 29, 467–470.CrossRefGoogle ScholarPubMed
Hamilton, M. (1959). The assessment of anxiety states by rating. British Journal of Medical Psychiatry 32, 50–55.CrossRefGoogle ScholarPubMed
Hamilton, M. (1967). Development of a rating scale for primary depressive illness. British Journal of Social and Clinical Psychology 6, 278–296.CrossRefGoogle ScholarPubMed
Petursson, H., Reveley, M. A., Glover, V. & Sandler, M. (1981). Urinary MAO inhibitor in psychiatric illness. Psychiatry Research 2, 335–340.CrossRefGoogle Scholar
Petursson, H., Bhattacharya, S. K., Glover, V., Sandler, M. & Lader, M. (1982). Urinary monoamine oxidase inhibitor and benzodiazepine withdrawal. British Journal of Psychiatry 140, 7–10.CrossRefGoogle ScholarPubMed
Sandler, M. (1982). The emergence of tribulin. Trends in Pharmacological Science 3, 471–472.CrossRefGoogle Scholar