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Protein folding

Published online by Cambridge University Press:  17 March 2009

George Némethy and
Harold A. Scheraga
George Némethy
Affiliation:
Department of Chemistry, Cornell University, Ithaca, New York 14853 (U.S.A.)
Harold A. Scheraga
Affiliation:
Department of Chemistry, Cornell University, Ithaca, New York 14853 (U.S.A.)
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Extract

This review describes recent advances in studies on the stabilities of the three-dimensional structures of proteins and on the processes leading to the formation of these structures. The term ‘protein folding’ will be used here to denote the process of the conversion of an open polypeptide chain into the unique three-dimensional conformation of the native protein. Experimental and theoretical aspects of protein folding have been reviewed by anfinsen & Scheraga (1975). In the present article, we emphasize advances made since the writing of that review, together with a brief summary of the background of recent studies.

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Research Article
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Quarterly Reviews of Biophysics , Volume 10 , Issue 3 , August 1977, pp. 239 - 352
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Copyright © Cambridge University Press 1977

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