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Cytoskeleton alteration correlates with gross structural plasticity in the cat lateral geniculate nucleus

Published online by Cambridge University Press:  04 October 2007

MATTHEW R. KUTCHER and
KEVIN R. DUFFY
MATTHEW R. KUTCHER
Affiliation:
Department of Psychology, Dalhousie University, Life Sciences Centre, Halifax, NS, Canada
KEVIN R. DUFFY
Affiliation:
Department of Psychology, Dalhousie University, Life Sciences Centre, Halifax, NS, Canada
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Abstract

Monocular deprivation during early development causes rearrangement of neural connections within the visual cortex that produces a shift in ocular dominance favoring the non-deprived eye. This alteration is manifested anatomically within deprived layers of the lateral geniculate nucleus (LGN) where neurons have smaller somata and reduced geniculocortical terminal fields compared to non-deprived counterparts. Experiments using monocular deprivation have demonstrated a spatial correlation between cytoskeleton alteration and morphological change within the cat LGN, raising the possibility that subcellular events mediating deprivation-related structural rearrangement include modification to the neuronal cytoskeleton. In the current study we compared the spatial and temporal relationships between cytoskeleton alteration and morphological change in the cat LGN. Cross-sectional soma area and neurofilament labeling were examined in the LGN of kittens monocularly deprived at the peak of the critical period for durations that ranged from 1 day to 7 months. After 4 days of deprivation, neuron somata within deprived layers of the LGN were significantly smaller than those within non-deprived layers. This structural change was accompanied by a spatially coincident reduction in neurofilament immunopositive neurons that was likewise significant after 4 days of deprivation. Both anatomical effects reached close to their maximum by 10 days of deprivation. Results from this study demonstrate that alteration to the neuronal cytoskeleton is both spatially and temporally linked to the gross structural changes induced by monocular deprivation.

Keywords

Monocular DeprivationCytoskeletonNeurofilamentCytostructureLateral Geniculate Nucleus

Information

Type
Research Article
Information
Visual Neuroscience , Volume 24 , Issue 6 , November 2007, pp. 775 - 785
Copyright
2007 Cambridge University Press

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