Hostname: page-component-7b7567c8c-7pwfn Total loading time: 0 Render date: 2026-11-15T22:53:01.122Z Has data issue: false hasContentIssue false
  • English
  • Français

Very virulent Marek's disease viruses: importance and control

Published online by Cambridge University Press:  18 September 2007

Richard L. Witter
Richard L. Witter
Affiliation:
USDA/ARS Regional Poultry Research Laboratory, 3606 East Mount Hope Road, East Lansing, Michigan 48823, USA
Get access

Abstract

The emergence of viral strains of increased virulence has been associated with increased Marek's disease losses in certain vaccinated flocks. Methods are described for the isolation and typing of these strains, and for their control by means of improved vaccines.

Keywords

Marek's diseasevaccinationvirulencevirus

Information

Type
Research Article
Information
World's Poultry Science Journal , Volume 45 , Issue 1 , March 1989, pp. 60 - 65
Copyright
Copyright © Cambridge University Press 1989

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

Eidson, C.S., Page, R.K. and Kleven, S.H. (1978) Effectiveness of cell-free or cell-associated turkey herpesvirus vaccine against Marek's disease in chickens as influenced by maternal antibody, vaccine dose, and time of exposure to Marek's disease virus. Avian Dis. 22: 583–597CrossRefGoogle ScholarPubMed
De Boer, G.F., Groenendal, J.E., Boerrigter, H.M., Kok, G.L. and Pol, J.M.A. (1986) Protective efficacy of Marek's disease virus (MDV) CVI-988 CEF65 clone C against challenge infection with three very virulent MDV strains. Avian Dis. 30: 276–283CrossRefGoogle ScholarPubMed
Lee, L.F., Liu, X. and Witter, R.L. (1983) Monoclonal antibodies with specificity for three different serotypes of Marek's disease viruses in chickens. J. Immunol. 130: 1003–1006CrossRefGoogle ScholarPubMed
Powell, P.C. and Lombardini, F. (1986) Isolation of very virulent pathotypes of Marek's disease virus from vaccinated chickens in Europe. Vet. Rec. 118: 688–691CrossRefGoogle ScholarPubMed
Rispens, B.H., Van Vloten, H., Maas, H.J. and Hendrik, J.L. (1972) Control of Marek's disease in the Netherlands. I. Isolation of an avirulent Marek's disease virus (strain CVI 988) and its use in laboratory vaccination trials. Avian Dis. 16: 108–125CrossRefGoogle ScholarPubMed
Schat, K.A., Calnek, B.W. and Fabricant, J. (1982) Characterization of two highly oncogenic strains of Marek's disease virus. Avian Pathol. 11: 593–606CrossRefGoogle ScholarPubMed
Vielitz, E. and Landgraf, H. (1986) Protection against Marek's disease with different vaccines, determination of PD50 and duration of vaccinal immunity. Dtsch. tierarztl. Wochenschr. 93: 53–55Google Scholar
Witter, R.L. (1982) Protection by attenuated and polyvalent vaccines against highly virulent strains of Marek's disease virus. Avian Pathol. 11: 49–62CrossRefGoogle ScholarPubMed
Witter, R.L. (1983) Characteristics of Marek's disease viruses isolated from vaccinated commercial chicken flocks: association of viral pathotype with lymphoma frequency. Avian Dis. 27: 113–132CrossRefGoogle ScholarPubMed
Witter, R.L. and Lee, L.F. (1984) Polyvalent Marek's disease vaccines: safety, efficacy and protective synergism in chickens with maternal antibodies. Avian Pathol. 13: 75–92CrossRefGoogle ScholarPubMed
Witter, R.L., Sharma, J.M. and Fadly, A.M. (1980) Pathogenicity of variant Marek's disease virus isolants in vaccinated and unvaccinated chickens. Avian Dis. 24: 210–232CrossRefGoogle Scholar
Witter, R.L. (1987) New serotype 2 and attenuated serotype 1 Marek's disease vaccine viruses: comparative efficacy. Avian Dis. 31: 752–765CrossRefGoogle ScholarPubMed