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Dysphonia following anterior cervical discectomy and fusion: a PearlDiver analysis of incidence, risk factors, and interventions

Published online by Cambridge University Press:  07 May 2026

Nancy Deng
Affiliation:
College of Medicine, State University of New York (SUNY) Downstate Health Sciences University, Brooklyn, NY, USA
James Cochran
Affiliation:
Department of Otolaryngology, State University of New York (SUNY) Downstate Health Sciences University, Brooklyn, NY, USA
Ameer Tabbaa
Affiliation:
Department of Orthopedics, Maimonides Health, Brooklyn, NY, USA
Afshin Razi
Affiliation:
Department of Orthopedics, Maimonides Health, Brooklyn, NY, USA
Sara Abu-Ghanem*
Affiliation:
Department of Otolaryngology, State University of New York (SUNY) Downstate Health Sciences University, Brooklyn, NY, USA Division of Otolaryngology, Maimonides Health, Brooklyn, NY, USA
*
Corresponding author: Sara Abu-Ghanem; Email: abughane@gmail.com
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Abstract

Objective

This study aimed to determine the incidence of post-operative dysphonia following anterior cervical discectomy and fusion, identify associated risk factors and assess utilisation of diagnostic and therapeutic interventions.

Methods

This retrospective cohort study analysed data from the PearlDiver Mariner Patient Records Database (2010–2022). Adults (≥18 years) undergoing primary anterior cervical discectomy and fusion without pre-existing dysphonia were included (n = 613,978). Outcomes included incidence, risk factors (odds ratios, 95 per cent confidence intervals) and intervention rates.

Results

Dysphonia occurred in 2.6 per cent of patients. Risk factors included female sex (odds ratio 1.43), age 50–64 (odds ratio 1.10), 65–79 (odds ratio 1.21), smoking (odds ratio 2.41), obesity (odds ratio 2.80), diabetes (odds ratio 1.89) and multilevel anterior cervical discectomy and fusion (odds ratio 1.20) (p < 0.01). Diagnosis was delayed (>12 months) in 73.2 per cent. Only 52.7 per cent underwent laryngoscopy; 15.0 per cent received voice therapy.

Conclusion

Post-operative dysphonia is under-recognised and undertreated. Structured screening and otolaryngology referral pathways may improve diagnosis and management.

Information

Type
Main Article
Copyright
© Sara Abu-Ghanem, 2026. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED.
Figure 0

Figure 1. Within the group of patients with a new dysphonia code post-operatively, 15,666 had data available regarding the timing of diagnosis.Figure 1 long description.

Figure 1

Table 1. Demographics of patients undergoing primary anterior cervical discectomy and fusion (ACDF) surgeryTable 1 long description.

Figure 2

Table 2. Demographic data stratified by cohort with associated odds ratio for dysphonia diagnosisTable 2 long description.

Figure 3

Table 3. Procedure-related variables of interest with associated odds ratio for dysphoniaTable 3 long description.

Figure 4

Table 4. Pre- and post-operative interventions of interest and odds ratiosTable 4 long description.