1 Introduction
Microfluidic systems have been shown to be very useful for continuous manipulation and separation of microparticles with increased control and sensitivity, which is important for a wide range of applications in chemistry, biology and medicine. Traditional microfluidic techniques of particle manipulation rely on low Reynolds number laminar flow. Under these conditions, when no external forces are applied, particles follow fluid streamlines. Contrary to this, particles migrate across streamlines to some stationary positions in microchannels when inertial aspects of the flow become significant. This migration is attributed to inertial lift forces, which are currently successfully used in microfluidic systems to focus and separate particles of different sizes continuously, at high flow rate, and without external forces (Di Carlo et al. Reference Di Carlo, Irimia, Tompkins and Toner2007; Bhagat, Kuntaegowdanahalli & Papautsky Reference Bhagat, Kuntaegowdanahalli and Papautsky2008). The rapid development of inertial microfluidics has raised a considerable interest in the lift forces on particles in confined flows. We mention below what we believe are the most relevant contributions.
Inertial lift forces on neutrally buoyant particles have been originally reported for macroscopic channels (Segré & Silberberg Reference Segré and Silberberg1962). This pioneering work has concluded that particles focus to a narrow annulus at radial position
$0.6$
of a pipe radius, and argued that lift forces vanish at this equilibrium position. However, no particle manipulation systems have been explored based on macroscale systems. Much later this inertial focusing has provided the basis for various methods of particle separation by size or shape in microfluidics devices (see Martel & Toner (Reference Martel and Toner2014) and Zhang et al. (Reference Zhang, Yan, Yuan, Alici, Nguyen, Warkiani and Li2016) for recent reviews). In these microfluidic applications the inertial lift has been balanced by the Dean force due to a secondary rotational flow caused by inertia of the fluid itself, which can be generated in curved channels (Bhagat et al.
Reference Bhagat, Kuntaegowdanahalli and Papautsky2008). These Dean drag forces alter the equilibrium positions of the particles. The preferred location of particles in microchannels could also be controlled by the balance between inertial lift and external forces, such as electric (Zhang et al.
Reference Zhang, Yan, Alici, Nguyen, Di Carlo and Li2014) or magnetic (Dutz, Hayden & Häfeli Reference Dutz, Hayden and Häfeli2017).
In recent years extensive efforts have gone into experimentally investigating particle equilibrium positions in cylindrical (Matas, Morris & Guazzelli Reference Matas, Morris and Guazzelli2004; Morita, Itano & Sugihara-Seki Reference Morita, Itano and Sugihara-Seki2017) and rectangular channels (Choi, Seo & Lee Reference Choi, Seo and Lee2011; Miura, Itano & Sugihara-Seki Reference Miura, Itano and Sugihara-Seki2014; Hood et al.
Reference Hood, Kahkeshani, Di Carlo and Roper2016). Matas et al. (Reference Matas, Morris and Guazzelli2004) have shown that the Segré–Silberberg annulus for neutrally buoyant particles shifts toward the wall as Reynolds number,
$Re$
, increases and toward the pipe centre as particle size increases. At large
$Re\geqslant 600$
, some particles accumulate in an inner annulus near the pipe centre. Morita et al. (Reference Morita, Itano and Sugihara-Seki2017) have found that the inner annulus is not a true equilibrium position, but a transient zone, and that in a long enough pipe all particles accumulate within the Segré–Silberberg annulus. It has also been found that equilibrium positions of slightly non-neutrally buoyant particles in a horizontal pipe are shifted toward the pipe bottom (Matas et al.
Reference Matas, Morris and Guazzelli2004).
During last several years numerical calculations (Di Carlo et al. Reference Di Carlo, Edd, Humphry, Stone and Toner2009; Liu et al. Reference Liu, Hu, Jiang and Sun2015; Loisel et al. Reference Loisel, Abbas, Masbernat and Climent2015) and computer simulations (Chun & Ladd Reference Chun and Ladd2006; Kilimnik, Mao & Alexeev Reference Kilimnik, Mao and Alexeev2011) have also been concerned with phenomena of the inertial migration. It has been shown that in rectangular channels particles initially migrate rapidly to manifolds, and then slowly focus within the manifolds to stable equilibrium positions near wall centres and channel corners (Chun & Ladd Reference Chun and Ladd2006; Di Carlo et al. Reference Di Carlo, Edd, Humphry, Stone and Toner2009; Hood et al. Reference Hood, Kahkeshani, Di Carlo and Roper2016). There could be two, four or eight equilibrium positions depending on the particle size, channel aspect ratio and Reynolds number. Overall, simulations are consistent with experimental results (Choi et al. Reference Choi, Seo and Lee2011; Miura et al. Reference Miura, Itano and Sugihara-Seki2014; Hood et al. Reference Hood, Kahkeshani, Di Carlo and Roper2016).
There is also a large literature describing attempts to provide a theory of inertial lift. An asymptotic approach, which can shed light on these phenomena, has been developed by several authors (Saffman Reference Saffman1965; Ho & Leal Reference Ho and Leal1974; Vasseur & Cox Reference Vasseur and Cox1976; Cox & Hsu Reference Cox and Hsu1977; Schonberg & Hinch Reference Schonberg and Hinch1989; Asmolov Reference Asmolov1999; Matas et al.
Reference Matas, Morris and Guazzelli2004; Matas, Morris & Guazzelli Reference Matas, Morris and Guazzelli2009). Most papers have considered a plane Poiseuille flow, except the work by Matas et al. (Reference Matas, Morris and Guazzelli2009) where a pipe flow has been addressed. The approach can be applied when the particle Reynolds number,
$Re_{p}=a^{2}G/\unicode[STIX]{x1D708}$
, where
$a$
is the particle radius,
$G$
is the characteristic shear rate and
$\unicode[STIX]{x1D708}$
is the kinematic viscosity, is small. If so, to the leading order in
$Re_{p}$
, the disturbance flow is governed by the Stokes equations, and a spherical particle experiences a drag and a torque, but no lift. The Stokeslet disturbance originates from the particle translational motion relative to the fluid and is proportional to the slip velocity
$V_{s}^{\prime }=V^{\prime }-U^{\prime }$
, where
$V^{\prime }$
and
$U^{\prime }$
are forward velocities of the particle and of the undisturbed flow at the particle centre. The stresslet is induced by free rotation of the sphere in the shear flow and is proportional to
$G$
. The lift force has then been deduced from the solution of the next-order equations which accounts a nonlinear coupling between the two disturbances (Vasseur & Cox Reference Vasseur and Cox1976):
where
$\unicode[STIX]{x1D70C}$
is the fluid density. The coefficients
$c_{li}$
(
$i=0,1,2$
) generally depend on several dimensionless parameters, such as
$z/a$
,
$H/a$
,
$V_{s}^{\prime }/U_{m}^{\prime }$
and on the channel Reynolds number,
$Re=U_{m}^{\prime }H/\unicode[STIX]{x1D708}$
, where
$z$
is the distance to the closest wall,
$H$
is the channel thickness and
$U_{m}^{\prime }$
is the maximum velocity of the channel flow. Solutions for
$c_{l}$
have been obtained in some limiting cases only, and no general analytical equations have yet been proposed for finite-size particles in a channel. Thus, Vasseur & Cox (Reference Vasseur and Cox1976) have calculated the coefficients
$c_{l0}^{VC},c_{l1}^{VC},c_{l2}^{VC}$
for point-like particles at small channel Reynolds numbers,
$Re\ll 1$
, which depend on
$z/H$
only and are applicable when
$z\gg a$
. Cherukat & McLaughlin (Reference Cherukat and McLaughlin1994) have later evaluated the coefficients
$c_{li}^{CM}(z/a)$
for finite-size particles near a single wall in a linear shear flow assuming that
$z\sim a$
and proposed simple fits for them. However, it remains unclear if and how earlier theoretical results for point-like particles at
$Re\ll 1$
or for finite-size particles near a single wall can be generalized to predict the lift of finite-size particles at any
$z$
and a finite
$Re$
of a microfluidic channel.
According to equation (1.1) the contribution of the slip velocity to the lift forces dominates when
$V_{s}^{\prime }\gg Ga$
. Since the slip velocity is induced by external forces, such as gravity, it is believed that it impacts a hydrodynamic lift only in the case of non-neutrally buoyant particles. For neutrally buoyant particles with equal to
$\unicode[STIX]{x1D70C}$
density, the slip velocity is normally considered to be negligibly small (Ho & Leal Reference Ho and Leal1974; Hood, Lee & Roper Reference Hood, Lee and Roper2015). A corollary from that would be that the lift of neutrally buoyant particles could be due to the stresslet only. Such a conclusion, however, can be justified theoretically only for small particles far from walls,
$z\gg a$
, but hydrodynamic interactions at finite distances
$z\sim a$
can induce a finite slip,
$V_{s}^{\prime }\sim Ga$
, so that all terms in (1.1) become comparable (Cherukat & McLaughlin Reference Cherukat and McLaughlin1994). The variation of the slip velocity of neutrally buoyant particles in a thin near-wall layer can impact the lift force, but we are unaware of any previous work that has addressed this question.
The purpose of this introduction has been to show that, in spite of its importance for inertial microfluidics, the lift forces of finite-size particles in a bounded geometry of a microchannel still remain poorly understood. In particular, there is still a lack of simple analytical formulas quantifying the lift, as well as of general solutions valid in the large range of parameters typical for real microfluidic devices. Given the current upsurge of interest in the inertial hydrodynamic phenomena and their applications to separation of particles in microfluidic devices it would seem timely to provide a more satisfactory theory of a hydrodynamic lift in a microchannel and also to bring some of modern simulation techniques to bear on this problem. In this paper we present some results of a study of a migration of finite-size particles at moderate channel Reynolds numbers,
$Re\sim 10$
, with the special focus on the role of the slip velocity in the hydrodynamic lift.
Our paper is arranged as follows. In § 2 we propose a general expression for the lift force on a neutrally buoyant particle in a microchannel, which reduces to earlier theoretical results (Vasseur & Cox Reference Vasseur and Cox1976; Cherukat & McLaughlin Reference Cherukat and McLaughlin1994) in relevant limiting cases. We also extend our expression to the case of slightly non-neutrally buoyant particles with the slip velocity smaller than
$Ga$
. To access the validity of the proposed theory we use a simulation method described in § 3, and the numerical results are presented in § 4. We conclude in § 5 with a discussion of our results and their possible relevance for a fractionation of particles in microfluidic devices. appendices A and B contain a summary of early calculations of lift coefficients and the derivation of differential equations that determine trajectories of particles.
Sketch of a migration of a particle of radius
$a$
to an equilibrium position in a pressure-driven flow. The locus of this position is determined by the balance between lift,
$F_{l}^{\prime }$
, and gravity,
$F_{g}^{\prime }$
, forces.

2 Theory
In this section we propose an analytical expression for the lift force on neutrally buoyant and slightly non-neutrally buoyant particles of radius
$a$
, which translate parallel to a channel wall. Our expression is valid for
$a/H\ll 1$
at any distance
$z$
from the channel wall.
We consider a pressure-driven flow in a flat inclined microchannel of thickness
$H$
. An inclination angle
$\unicode[STIX]{x1D6FC}\geqslant 0$
is defined relative to the horizontal. The coordinate axis
$x$
is parallel to the channel wall, and the normal to the wall coordinate is denoted by
$z$
. The geometry is shown in figure 1. The undisturbed velocity profile in such a channel is given by
Let us now introduce a dimensionless slip velocity
$V_{s}=V_{s}^{\prime }/(aG_{m})$
, where
$G_{m}=4U_{m}^{\prime }/H$
is the maximum shear rate at the channel wall. We can then rewrite equation (1.1) as
with the lift coefficient
which depends on the slip velocity,
$V_{s}$
, which in turn can be determined from the Stokes equations (a zero-order solution). Therefore, to construct a general expression for a lift force acting on finite-size particles in a channel it is necessary to estimate
$V_{s}$
as a function of
$z$
.
We begin by studying the classical case of neutrally buoyant (i.e. force- and a torque-free) particles with a density
$\unicode[STIX]{x1D70C}_{p}$
equal to that of liquid,
$\unicode[STIX]{x1D70C}$
. The expression for
$V_{s}$
in a linear shear flow near a single wall has been derived before (Goldman, Cox & Brenner Reference Goldman, Cox and Brenner1967) and can be used to calculate the slip velocity in the near-wall region of our channel. The fits for
$V_{s}$
are given in appendix A, equations (A 2)–(A 4). We first note that depending on
$z/a$
one can distinguish between two different regimes of behaviour of
$V_{s}$
. In the central part of the channel, i.e. when
$z/a\gg 1$
, the slip contribution to the lift decays as
$(a/z)^{3}$
(Wakiya, Darabaner & Mason Reference Wakiya, Darabaner and Mason1967), being always very small, but finite. In contrast, when the gap between the sphere and the wall is small,
$z/a-1\ll 1$
, the slip velocity varies very rapidly with
$z/a$
(Goldman et al.
Reference Goldman, Cox and Brenner1967):
As a side note we should like to mention here that a logarithmic singularity in (2.4) implies that in the near-wall region the lift coefficient, equation (2.3), cannot be fitted by any power law
$(a/z)^{n}$
as has been previously suggested (Di Carlo et al.
Reference Di Carlo, Edd, Humphry, Stone and Toner2009; Hood et al.
Reference Hood, Lee and Roper2015; Liu et al.
Reference Liu, Xue, Sun and Hu2016).
It follows from (2.4) that for an immobile particle in a contact with the wall,
$z=a$
, the slip velocity is largest,
$V_{s}=-1$
. In this limiting case the lift coefficient also takes its maximum value,
$c_{l}^{KL}\simeq 9.257$
(Krishnan & Leighton Jr. Reference Krishnan and Leighton1995). Far from the wall, the slip velocity is much smaller and can be neglected, so that we can consider
$c_{l}\simeq c_{l0}$
. Therefore, when
$a\ll z\ll H$
, the value of
$c_{l}$
in (2.3) is equal to
$c_{l0}^{CV}|_{z/H\rightarrow 0}=55\unicode[STIX]{x03C0}/96\simeq 1.8$
(Cox & Hsu Reference Cox and Hsu1977), i.e. it becomes much smaller than for a particle at the wall. This illustrates that
$c_{l}$
varies significantly in the vicinity of the wall due to a finite slip.
We now remark that the Stokeslet contribution (the second and the third terms in (2.3)) is finite for
$z\sim a$
only and vanishes in the central part of the channel. Within the close proximity to the wall we may neglect the corrections to the slip and the lift of order
$a/H$
due to parabolic flow (Pasol, Sellier & Feuillebois Reference Pasol, Sellier and Feuillebois2006; Yahiaoui & Feuillebois Reference Yahiaoui and Feuillebois2010) and due to the second wall. Therefore, in this region one can use the results by Cherukat & McLaughlin (Reference Cherukat and McLaughlin1994) for the lift coefficients
$c_{li}^{CM}$
. The stresslet contribution to the lift (first term in (2.3)) is finite for any
$z$
. Close to the wall, the effect of particle size for this term is negligible as the coefficient
$c_{l0}^{CM}(z/a)$
is nearly constant (Cherukat & McLaughlin Reference Cherukat and McLaughlin1994). So we may describe the stresslet contribution by the coefficient
$c_{l0}^{VC}$
obtained by Vasseur & Cox (Reference Vasseur and Cox1976). This enables us to construct the following formula for the lift coefficient:
where
$\unicode[STIX]{x1D6FE}=G(z)/G_{m}=1-2z/H\leqslant 1$
is a dimensionless local shear rate at the particle position. The fitting expressions for three lift coefficients are summarized in appendix A. We, therefore, use (A 6) to calculate
$c_{l0}^{VC}$
, equation (A 9) to calculate
$c_{l1}^{CM}$
and equation (A 10) for
$c_{l2}^{CM}$
. Note that in the second term of (2.5) we have introduced a correction factor
$\unicode[STIX]{x1D6FE}$
, which takes into account the variation of
$G$
in the second term of (1.1) and ensures the lift remains zero at the channel centreline.
We recall, that equation (2.5) is asymptotically valid for any
$z$
when
$a/H\ll 1$
and
$Re\ll 1$
. However, one can argue that it should be accurate enough at moderate Reynolds numbers. Indeed, the contribution of undisturbed flow to inertial terms in the Navier–Stokes equations remains relatively small when
$Re\leqslant 20$
. With this reason constructed for
$Re\ll 1$
regular-perturbation methods (Ho & Leal Reference Ho and Leal1974; Vasseur & Cox Reference Vasseur and Cox1976; Cherukat & McLaughlin Reference Cherukat and McLaughlin1994) have successfully predicted the lift force on a point-like neutrally buoyant particle at a moderate
$Re$
. For larger
$Re$
, when a contribution of inertial terms becomes significant, the equilibrium positions should be shifted towards the wall with the increase in
$Re$
(Schonberg & Hinch Reference Schonberg and Hinch1989; Asmolov Reference Asmolov1999).
We now turn to non-neutrally buoyant particles, for which the density is different from that of the liquid, so that they experience an external gravity force,
$F_{g}^{\prime }$
, which in dimensionless form can be expressed as
where
$\unicode[STIX]{x0394}\unicode[STIX]{x1D70C}=(\unicode[STIX]{x1D70C}_{p}-\unicode[STIX]{x1D70C})/\unicode[STIX]{x1D70C}$
. The gravity influences both the particle migration and equilibrium position when
$F_{g}=O(1)$
. It also induces an additional slip velocity which is of the order of the Stokes settling velocity,
where
$\unicode[STIX]{x1D707}$
is the dynamic viscosity. The effect of this velocity on the lift is comparable to
$F_{l}^{nb}$
when
$V^{St}=O(1)$
, i.e. at large gravity,
$F_{g}\sim 6\unicode[STIX]{x03C0}Re_{p}^{-1}\gg 1$
, and is very important for vertical or nearly vertical channels. For horizontal channels, the slip velocity is equal to that of a neutrally buoyant sphere since
$F_{x}=0$
. Equation (2.5) can also be applied in this case since the slip velocity remains small far from walls. Equilibrium positions of particles,
$z_{eq}$
, can then be deduced from the balance between the lift and the gravity,
Equation (2.8) may have two, one or no stable equilibrium points depending on
$F_{g}$
, and the sensitivity of the equilibrium positions to the value of
$a$
or
$\unicode[STIX]{x0394}\unicode[STIX]{x1D70C}$
is defined by the value
$\unicode[STIX]{x2202}c_{l}/\unicode[STIX]{x2202}z$
. Thus, when the derivative is small, small variations in
$F_{g}$
will lead to a significant shift in focusing positions. We finally note that the range of possible
$z_{eq}$
can be tuned by the choice of
$U_{m}^{\prime }$
.
3 Simulation method
In this section, we present our simulation method and justify the choice of parameters.
For our computer experiment, we chose a scheme based on the lattice Boltzmann method (Benzi, Succi & Vergassola Reference Benzi, Succi and Vergassola1992; Kunert, Harting & Vinogradova Reference Kunert, Harting and Vinogradova2010; Dubov et al.
Reference Dubov, Schmieschek, Asmolov, Harting and Vinogradova2014) which has been successfully employed earlier to simulate a motion of particles in the channel flow. We use a simulation cell confined by two impermeable no-slip walls located at
$z=0$
and
$z=79\unicode[STIX]{x1D6FF}$
, so that in all simulations
$H=79\unicode[STIX]{x1D6FF}$
, and two periodic boundaries with
$N_{x}=N_{y}=256\unicode[STIX]{x1D6FF}$
, where
$\unicode[STIX]{x1D6FF}$
is the lattice spacing. Spherical particles of radii
$a=4\unicode[STIX]{x1D6FF}-12\unicode[STIX]{x1D6FF}$
are implemented as moving no-slip boundaries (Ladd & Verberg Reference Ladd and Verberg2001; Janoschek, Toschi & Harting Reference Janoschek, Toschi and Harting2010; Harting et al.
Reference Harting, Frijters, Ramaioli, Robinson, Wolf and Luding2014), where the chosen radii are sufficient to keep discretization effects of the order of a few per cent (Janoschek Reference Janoschek2013). A Poiseuille flow is generated by applying a body force, which is equivalent to a pressure gradient
$-\unicode[STIX]{x1D735}p$
. We use a three-dimensional, 19 velocity, single relaxation time implementation of the lattice Boltzmann method, where the relaxation time
$\unicode[STIX]{x1D70F}$
is kept to 1 throughout this paper. Different flow rates are obtained by changing the fluid forcing. We use two channel Reynolds numbers,
$Re=11.3$
and
$22.6$
. To simulate the migration in an inclined channel we apply the gravity force directed at an angle
$\unicode[STIX]{x1D6FC}$
relative to the
$z$
-axis at the centre of the particle. In our simulations the values of dimensionless
$F_{g}$
vary from
$0$
(neutrally buoyant particle) to
$13.91$
.
In our computer experiments we determine the lift by using two different strategies. In the first method we extract the lift from the migration velocity. We measure the
$x$
- and
$z$
-components of the particle velocity to find the dimensionless slip,
$V_{s}=(V_{x}^{\prime }-U^{\prime }(z))/(aG_{m})$
, and migration velocities,
$V_{m}=V_{z}^{\prime }/(aG_{m})$
. To suppress the fluctuations arising from the discretization artefacts we average the velocities over approximately 4000 time steps. The error does not exceed
$3\,\%$
for the particles with
$a=4$
and rapidly decreases with
$a$
. The lift force can then be found from these calculations, by assuming that the particle motion is quasi-stationary. The lift is balanced by the
$z$
-component of the drag,
$F_{l}^{\prime }=-F_{dz}^{\prime }$
. Following Dubov et al. (Reference Dubov, Schmieschek, Asmolov, Harting and Vinogradova2014) we use an expression
where the second and the third terms are corrections to the Stokes drag due to hydrodynamic interactions with two channel walls. In what follows
The second method to calculate the lift (and to check the validity of the first approach) uses the balance of the lift and the gravity forces described by (2.8). By varying the gravity force
$F_{g}$
one can, therefore, comprehend the whole range of equilibrium positions within the channel to obtain
$c_{l}(z)$
. The advantage of such an approach is that it does not require the particle motion to be quasi-stationary. However, the disadvantage of this method is that the convergence to equilibrium can be slow in the central zones of the channel, where the slope of
$c_{l}(z)$
is small. Therefore, we use this computational strategy only in the near-wall region.
4 Results and discussion
In this section, we present the lattice Boltzmann simulation results and compare them with theoretical predictions.
(a) Dimensionless migration velocity computed as a function of
$z/H$
for particles of
$a=4\unicode[STIX]{x1D6FF}$
(symbols). The location of the particle in a contact with the wall,
$z=a$
, is shown by a vertical dotted line. Dashed curve plots theoretical predictions for point-like particles. Solid curve shows a polynomial fit to simulation data. (b) Dimensionless slip velocities computed for the same particles (symbols). Solid curve plots the slip velocity in a linear shear flow near a single wall. Dashed line plots the Faxen correction. Vertical dotted line indicates the location of
$z=a$
.

4.1 Neutrally buoyant particles
We start with neutrally buoyant particles and first calculate their migration
$V_{m}^{nb}$
and the slip
$V_{s}^{nb}$
velocities as a function of
$z/H$
. Figure 2 plots simulation data obtained for particles of radius
$a=4\unicode[STIX]{x1D6FF}$
. Here we show only a half of the channel since the curves are antisymmetric with respect to the channel axis
$z=H/2$
. These results demonstrate that the migration velocity differs significantly from the velocity
$c_{l0}Re_{p}/(6\unicode[STIX]{x03C0})$
, where
$Re_{p}=a^{2}G_{m}/\unicode[STIX]{x1D708}$
, predicted theoretically for point-like particles (Vasseur & Cox Reference Vasseur and Cox1976). We also see that the equilibrium position,
$V_{m}^{nb}=0$
, of finite-size particles is shifted towards the channel axis compared to that of point-like particles, which is obviously due to their interactions with the wall resulting in a finite slip velocity. Indeed, figure 2(b) demonstrates that the computed
$V_{s}^{nb}$
grows rapidly near the wall, being close to the theoretical predictions for a linear shear flow near a single wall (Goldman et al.
Reference Goldman, Cox and Brenner1967). Unlike theoretical predictions by Goldman et al. (Reference Goldman, Cox and Brenner1967), the computed slip velocity does not vanish in the central part of the channel. Its value is roughly twice larger than the Faxen correction
$4U_{m}^{\prime }a^{2}/(3H^{2})$
(Happel & Brenner Reference Happel and Brenner1965). Note that a similar difference has been obtained in simulations of the migration of finite-size particles based on the force coupling method (Loisel et al.
Reference Loisel, Abbas, Masbernat and Climent2015). These deviations from the Faxen corrections are likely also caused by hydrodynamic interactions of particles with the wall in a parabolic flow.
Lift coefficient,
$c_{l}$
, for neutrally buoyant particles of
$a=4\unicode[STIX]{x1D6FF}$
(circles) and
$8\unicode[STIX]{x1D6FF}$
(squares) obtained from the migration velocity at
$Re=11.3$
(grey symbols) and
$22.6$
(white symbols). Solid and dash-dotted curves show predictions of (2.5) for
$a=4\unicode[STIX]{x1D6FF}$
and
$8\unicode[STIX]{x1D6FF}$
, dashed curve plots predictions for point-like particles. Vertical dotted lines show
$z=a$
. Black symbols show
$c_{l}$
obtained for non-neutrally buoyant particles of
$a=4\unicode[STIX]{x1D6FF}$
from the force balance at
$Re=22.6$
. The inset plots
$c_{l}$
in the central part of the channel.

Equilibrium positions for neutrally buoyant finite-size (grey circles) and point-like (white circle) particles. Dashed curve shows predictions of (2.5).

Figure 3 shows
$c_{l}$
for particles of
$a=4\unicode[STIX]{x1D6FF}$
and
$8\unicode[STIX]{x1D6FF}$
. The lift coefficient has been obtained from the migration velocity and from the force balance as specified above, and simulations have been made for two moderate Reynolds numbers,
$Re=11.3$
and
$22.6$
. As we discussed above, if
$Re\leqslant 20$
a potential dependence of
$c_{l}$
on
$Re$
could be ruled out a priori, and this is indeed confirmed by our simulations. Therefore, below we provide a detailed comparison of our simulation data with asymptotic solutions obtained for
$Re\ll 1$
, which should be applicable for finite moderate
$Re$
. Figure 3 also includes theoretical predictions by Vasseur & Cox (Reference Vasseur and Cox1976) and curves calculated with (2.5). One can see that simulation results show a strong discrepancy with the point-particle approximation, especially in the near-wall region, where hydrodynamic interactions are significant. This discrepancy increases with the size of particles. We can, however, conclude that predictions of our equation (2.5) are generally in good agreement with simulation results. Thus, for smaller particles, of
$a=4\unicode[STIX]{x1D6FF}$
, equation (2.5) perfectly fits the simulation data in the near-wall region, where the theory for point-like particles fails. Simulation results slightly deviate from predictions of (2.5) near the equilibrium positions and in the central part of the channel. For bigger particles, of
$a=8\unicode[STIX]{x1D6FF}$
, these deviations are more pronounced. We emphasize, however, that they are still much smaller than from the point-particle theory by Vasseur & Cox (Reference Vasseur and Cox1976).
To examine a significance of the particle size in more detail, we plot in figure 4(a) the computed equilibrium position,
$z_{eq}/H$
, as a function of
$a/H$
. We recall that the lift
$c_{l}^{nb}(z)$
is antisymmetric with respect to the midplane of the channel axis, so that neutrally buoyant particles have a second equilibrium position at
$H-z_{eq}$
. In a point-particle approximation
$z_{eq}/H\simeq 0.19$
(Vasseur & Cox Reference Vasseur and Cox1976). We see that for finite-size particles
$z_{eq}/H$
is always larger, and increases with the particle size. Note that the increase in
$z_{eq}/H$
is nearly linear when
$a/H\leqslant 0.1$
. Also included in figure 4 are predictions of (2.5). One can conclude that the theory correctly predicts the trend observed in simulations, but slightly deviates from the simulation data. A possible explanation for this discrepancy could be effects of parabolic flow (which are of the order of
$O(a/H)$
) on the slip velocity and the stresslet (see Yahiaoui & Feuillebois Reference Yahiaoui and Feuillebois2010; Hood et al.
Reference Hood, Lee and Roper2015), which are neglected in our theory.
4.2 Non-neutrally buoyant particles
We now turn to the particle migration under both inertial lift and gravity forces.
Migration velocity of non-neutrally buoyant particles in a horizontal channel. Symbols show simulation data. Solid curve is calculation with (4.1) using data for neutrally buoyant particles.

4.2.1 Horizontal channel
Let us start with the investigation of migration of particles in the most relevant experimental case of a horizontal channel (
$\unicode[STIX]{x1D6FC}=0^{\circ }$
).
We first fix a weak gravity force,
$F_{g}=0.694$
, and compute the migration velocity of particles of radii
$a=4\unicode[STIX]{x1D6FF}$
in a horizontal channel. Simulation results are plotted in figure 5. We see that
$V_{m}(z)$
is no longer antisymmetric, as it has been in the case of neutrally buoyant particles. The migration velocity can be calculated as
where we use a fit for
$V_{m}^{nb}$
computed for neutrally buoyant particles (see figure 2
a). The agreement between simulation data and calculations using (4.1) is excellent, which confirms that (2.5) remains valid in the case of slightly non-neutrally buoyant particles. We remark that due to gravity
$V_{m}$
is shifted downwards relative to
$V_{m}^{nb}(z)$
, shown in figure 2. As a result, with the taken value of
$F_{g}$
the second equilibrium position disappeared.
We recall that this type of simulations allows one to find values of
$c_{l}(z)$
in the vicinity of the wall by varying
$F_{g}$
. We have included these force balance results in figure 3 and can conclude that they agree very well with data obtained by using another computational method and for neutrally buoyant particles. This suggests again that above results could be used at moderate Reynolds numbers,
$Re\leqslant 20$
, since in this case the lift coefficient does not depend on
$Re$
.
(a) Equilibrium positions of non-neutrally buoyant particles (
$a=4\unicode[STIX]{x1D6FF}$
) in a horizontal channel; (b) trajectories of the same particles released at
$z_{0}=1.125a$
computed at different
$F_{g}=0.268$
(squares),
$0.804$
(diamonds),
$1.340$
(triangles),
$2.681$
(circles),
$9.383$
(diamonds).

Figure 6(a) shows
$z_{eq}/a$
computed at several
$F_{g}$
. It can be seen that when the gravity force is getting larger, the equilibrium positions decrease rapidly. This trend can be used to separate particles even when
$\unicode[STIX]{x0394}\unicode[STIX]{x1D70C}$
is very small. To illustrate this we now fix
$Re=11.3$
, inject particles of
$a=4\unicode[STIX]{x1D6FF}$
close to the bottom of the channel,
$z_{0}=1.125a$
and simulate their trajectories at different
$F_{g}$
. In figure 6(b) we plot trajectories of particles,
$z/a$
, as a function of
$xG_{m}a\unicode[STIX]{x1D708}$
. The data show that if
$F_{g}$
is large enough, particles sediment to the wall. However, when
$F_{g}$
is relatively small, particles follow different and divergent trajectories, by approaching their equilibrium positions. We stress that at a given
$F_{g}$
and
$a/H$
trajectories, shown figure 6(b), remain the same for any
$Re\leqslant 20$
(see appendix B). Therefore, even in the case of very small
$\unicode[STIX]{x0394}\unicode[STIX]{x1D70C}$
, one can always tune the value of
$Re$
to induce the required separation difference in
$F_{g}$
. For example, we have to separate particles of
$a=2~\unicode[STIX]{x1D707}$
m and different
$\unicode[STIX]{x0394}\unicode[STIX]{x1D70C}$
in a channel of
$H=40~\unicode[STIX]{x1D707}$
m. If we chose
$Re=0.3$
, the separation length
$L=50xG_{m}a\unicode[STIX]{x1D708}$
of figure 6(b) will be approximately
$3.3$
cm. By evaluating
$\unicode[STIX]{x0394}\unicode[STIX]{x1D70C}$
with (2.6), we can immediately conclude that trajectories plotted in figure 6(b) from top to bottom correspond to
$\unicode[STIX]{x0394}\unicode[STIX]{x1D70C}=0.007$
,
$0.022$
,
$0.037$
and
$0.073$
, which are indeed extremely small.
4.2.2 Inclined channel
When
$F_{g}$
is large enough, it can also influence the slip velocity, and therefore, change the lift itself. This effect is especially important for vertical channels. Note that due to the linearity of the Stokes equations, which govern a disturbance flow at small particle Reynolds numbers, we can decouple the contributions of the particle–wall interaction and of the gravity force into the slip velocity:
where
$\unicode[STIX]{x0394}V_{s}=V^{St}/f_{x}$
is the gravity-induced slip velocity for a vertical channel (
$\unicode[STIX]{x1D6FC}=90^{\circ }$
) and
$f_{x}(z/H,a/H)$
is the correction to the drag for a particle translating parallel to the channel walls. The slip and the migration velocities of particles of
$a=4\unicode[STIX]{x1D6FF}$
in a vertical channel computed by using several values of
$F_{g}$
are shown in figures 7(a) and 8(a). Note that the slip velocity,
$V_{s}$
, grows with
$F_{g}$
since the Stokes velocity,
$V^{St}$
, is linearly proportional to
$F_{g}$
(see (2.7)). We now use simulation data presented in figures 2(a) and 7(a) to compute
$\unicode[STIX]{x0394}V_{s}$
, and then
$\unicode[STIX]{x0394}V_{s}/F_{g}$
. The results for
$\unicode[STIX]{x0394}V_{s}/F_{g}$
are shown in figure 7(b), and we see that all data collapse into a single curve, which confirms the validity of (4.2). Figure 7(b) also shows that
$\unicode[STIX]{x0394}V_{s}/F_{g}$
is nearly constant in the central region of the channel, being smaller than
$V^{St}$
, but the deviations from
$V^{St}$
grow when particles approach the wall. These results again illustrate that hydrodynamic interactions with the walls significantly affect the motion of particles in the channel.
Slip velocities (a) and
$\unicode[STIX]{x0394}V_{s}/F_{g}$
(b) computed for non-neutrally buoyant particles of
$a=4\unicode[STIX]{x1D6FF}$
in a vertical channel. The data sets correspond to
$F_{g}=3.475$
(circles),
$6.956$
(triangles),
$10.44$
(squares) and
$13.91$
(diamonds). Dashed line shows
$V^{St}/F_{g}$
, vertical dotted lines plot
$z=a$
.

Migration velocities (a) and
$\unicode[STIX]{x0394}V_{m}/F_{g}$
(b) computed for non-neutrally buoyant particles of
$a=4\unicode[STIX]{x1D6FF}$
in a vertical channel. The data sets correspond to
$F_{g}=3.475$
(circles),
$6.956$
(triangles),
$10.44$
(squares) and
$13.91$
(diamonds). Vertical dotted lines plot
$z=a$
. Solid curve shows a polynomial fit of data.

We recall that the variation of the slip velocity caused by gravity is small for slightly non-neutrally buoyant particles (see figure 7), so that (2.5) can be linearized with respect to
$\unicode[STIX]{x0394}V_{s}$
:
where
$c_{l}^{nb}=c_{l}(V_{s}^{nb})$
is the lift coefficient for neutrally buoyant particles. By using (3.3) we can then calculate the migration velocity
The computed migration velocity is shown in figure 8(a). We see that it decreases with
$F_{g}$
, and the equilibrium position shifts towards the wall, since
$\unicode[STIX]{x0394}V_{s}/F_{g}$
is positive while
$\unicode[STIX]{x2202}c_{l}/\unicode[STIX]{x2202}V_{s}$
is negative.
We can now evaluate
$\unicode[STIX]{x0394}V_{m}/F_{g}$
by using the simulation data presented in figures 2 and 8(a), and these results are presented in figure 8(b). As one can see, the data collapse into a single curve, thus confirming the validity of our linearization, equation (4.4).
Finally, we briefly discuss the case of an arbitrary inclination angle
$\unicode[STIX]{x1D6FC}$
, where the
$z$
-component of the force can be written as
By using (4.2), (4.4) and (4.5), we can express the migration velocity as
where
$\unicode[STIX]{x0394}V_{m}$
is evaluated for a vertical channel (see figure 8
b). The equilibrium positions can be found by using the condition
$V_{m}=0$
, where
$V_{m}$
is calculated with (4.6). The results of these calculations, made at a fixed
$F_{g}=3.475$
and different
$\unicode[STIX]{x1D6FC}$
, are plotted in figure 9 together with direct simulation data, and one can see that they practically coincide. Our results show that in a vertical channel two stable equilibrium positions coexist. They are symmetric relative to the midplane and are located close to walls. Another, third equilibrium position has a locus at the midplane, but is unstable. A similar result has been obtained earlier (Vasseur & Cox Reference Vasseur and Cox1976; Asmolov Reference Asmolov1999). If we slightly reduce
$\unicode[STIX]{x1D6FC}$
both stable equilibrium positions become shifted towards the lower wall due to gravity, as seen in figure 9. These two positions coexist only for
$\unicode[STIX]{x1D6FC}\geqslant 85.7^{\circ }$
. On reducing
$\unicode[STIX]{x1D6FC}$
further the upper equilibrium position disappears, and only one, a lower, equilibrium position remains. This obviously indicates that the inertial lift cannot balance gravity anymore. We note that this remaining single equilibrium position becomes insensitive to the inclination angle when
$\unicode[STIX]{x1D6FC}\leqslant 60^{\circ }$
.
Equilibrium positions
$z_{eq}/H$
for
$a=4\unicode[STIX]{x1D6FF}$
and
$F_{g}=3.475$
. Circles show simulation data. Solid curve plots results obtained using
$V_{m}=0$
, where
$V_{m}$
is calculated with (4.6).

5 Concluding remarks
In this paper we have studied the inertial migration of finite-size particles in a plane channel flow at moderate Reynolds numbers,
$Re\leqslant 20$
. We have shown that the slip velocity,
$V_{s}$
, which is finite even for neutrally buoyant particles, contributes to the lift and determines the equilibrium positions in the channel. We have proposed an expression for the lift which generalizes theories, originally applied for some cases of limited guidance, to finite-size particles in a channel flow. When the size of the particle is zero, our formula recovers the known expression of the point-particle approximation (Vasseur & Cox Reference Vasseur and Cox1976). For particles close to the walls we recover earlier predictions for finite-size particles in a linear shear flow (Cherukat & McLaughlin Reference Cherukat and McLaughlin1994). Our theoretical model, which is probably the simplest realistic model for lift in a channel that one might contemplate, provides considerable insight into inertial migration of finite-size particles in microchannels. In particular, it provides a simple explanation of a significant increase in the lift near walls. It also allows one to predict the number of equilibrium positions and determine their locations in various situations.
To check the validity of our theory, we have employed lattice Boltzmann simulations. Generally, the simulation results have fully confirmed the theory, and have shown that many of our theoretical results have validity beyond the initial restrictions of our model. Thus, it has been confirmed that the predictions of our theory do not depend on Reynolds number when
$Re\leqslant 20$
, that equilibrium positions of heavy particles in a horizontal channel can be accurately determined by using data for the neutrally buoyant case, and more.
Several of our theoretical predictions could be tested by experiment. In particular, we have shown that particles with a very small density contrast should follow divergent trajectories, so that channel flows with low Reynolds numbers
$Re\sim 1$
can be used to separate such particles. We stress that our theory should correctly predict the lift in near-wall regions also in pipes or square channels, and we expect that for this geometry it could be accurate even at
$Re\geqslant 20$
since the length scale of the disturbance flow would be the distance to the wall rather than the channel width. For this reason it would be possible to neglect the effects of other distant walls and parabolic flow on the lift. Note, however, that these effects should be taken into account in the central part of the channel.
Our model and computational approach can be extended to more complex situations, which include, for example, hydrophobic walls or particles allowing hydrodynamic slip at their surfaces (Vinogradova Reference Vinogradova1999; Neto et al. Reference Neto, Evans, Bonaccurso, Butt and Craig2005). In this case the hydrodynamic interaction in the near-wall region changes significantly (Davis, Kezirian & Brenner Reference Davis, Kezirian and Brenner1994; Vinogradova Reference Vinogradova1996), so that we expect that the lift force can also be dramatically modified. It would also be interesting to consider the case of an anisotropic superhydrophobic wall, which could induce secondary flows transverse to the direction of applied pressure gradient (Feuillebois, Bazant & Vinogradova Reference Feuillebois, Bazant and Vinogradova2010; Vinogradova & Belyaev Reference Vinogradova and Belyaev2011; Schmieschek et al. Reference Schmieschek, Belyaev, Harting and Vinogradova2012). It has been recently shown (Pimponi et al. Reference Pimponi, Chinappi, Gualtieri and Casciola2014; Asmolov et al. Reference Asmolov, Dubov, Nizkaya, Kuehne and Vinogradova2015) that particles translating in a superhydrophobic channel can be laterally displaced due to such a transverse flow. The use of this effect in combination with the inertial migration should be a fruitful direction, which could allow us to separate particles of different size or density contrast not only by their vertical but also by their transverse positions.
Acknowledgements
We thank S. Schmieschek and M. Zellhöfer for their help on technical aspects of the simulations. This research was partly supported by the Russian Foundation for Basic Research (grant 15-01-03069).
Appendix A. Fits for the slip velocity and the lift coefficients
In this appendix we summarize known results for the slip velocity and the lift coefficients for finite-size particles in a linear shear flow near a single wall and for point-like particles in a Poiseuille flow. The velocity of a freely translating and rotating particle in a linear shear flow is given by (Goldman et al. Reference Goldman, Cox and Brenner1967)
where
$h$
is the correction function which depends on
$z/a$
only. We use (A 1) to estimate the slip velocity in channel flow, i.e. we neglect the effects due to parabolic flow, so that
The correction factor fitting the results by Goldman et al. (Reference Goldman, Cox and Brenner1967) in the near-wall region reads (Reschiglian et al. Reference Reschiglian, Melucci, Torsi and Zattoni2000)
where
$\unicode[STIX]{x1D701}=z/a$
and
$b=\log (\unicode[STIX]{x1D701}-1)$
. Note that here we have reformulated the original equation (Reschiglian et al.
Reference Reschiglian, Melucci, Torsi and Zattoni2000) in terms of the natural logarithm. For larger distances we use the asymptotic solution by Wakiya et al. (Reference Wakiya, Darabaner and Mason1967),
Vasseur & Cox (Reference Vasseur and Cox1976) have obtained the lift force on a particle in a channel flow at
$Re\ll 1$
by using a point-particle approximation:
where coefficients
$c_{l0}^{VC},c_{l1}^{VC},c_{l2}^{VC}$
depend on
$z/H$
only. Later Feuillebois (Reference Feuillebois2004) proposed a simple fitting expression:
The expression for a lift coefficient of a finite-size particle in a linear shear flow near a single wall has been suggested by Cherukat & McLaughlin (Reference Cherukat and McLaughlin1994)
where the coefficients
$c_{l0}^{CM},c_{l1}^{CM},c_{l2}^{CM}$
depend on
$\unicode[STIX]{x1D701}$
only:
Appendix B. Governing equations for trajectories of particles
In this appendix, we derive equations which govern particle trajectories. The components of the particle velocity can be written as
The last equality indicates that the migration time, i.e. the time required for a particle to migrate at distance of the order of its radius
$a$
, is equal to
$\unicode[STIX]{x1D708}/(G_{m}a)^{2}=(4G_{m}Re)^{-1}(H/a)^{2}.$
Since the right-hand sides of (B 1) and (B 2) do not explicitly include time, one can formulate an equation governing the particle trajectory as
Let us now turn to dimensionless coordinates
$\unicode[STIX]{x1D701}$
and
$\unicode[STIX]{x1D709}=xG_{m}a/\unicode[STIX]{x1D708}$
. Equation (B 3) can then be rewritten as
We stress that (B 4) does not depend on
$Re$
. Indeed,
$f_{z}$
and
$h$
are dimensionless functions of
$\unicode[STIX]{x1D701}$
and
$a/H$
only, and the lift coefficient,
$c_{l}$
, is also not sensitive to the Reynolds number when
$Re\leqslant 20$
. This implies that at given
$F_{g}$
and
$a/H$
trajectories satisfying (B 4) are universal, i.e. remain the same at any
$Re\leqslant 20$
.









