This report describes a study “Genetic indicators for the GLOBIO model” undertaken as part of the project “Widening the analytical scope of GLOBIO3 – modelling global biodiversity”. The work focuses on the development of key biodiversity indicators for crops and livestock in agriculture with the ultimate objective of using these indicators for modelling global trends in agricultural biodiversity. Potential indicators proposed in the literature are reviewed and criteria for the selection of indicators are discussed. Two case studies in which various indicators are tested using data from the Netherlands and Germany are described. A conceptual framework for intraspecific agrobiodiversity describing factors driving changes in genetic diversity is proposed. This is followed by the results of a literature review undertaken in order to determine whether the level of genetic diversity can be understood as a resultant of the factors described in the conceptual framework. It focuses on major global drivers of change and shows which factors determine the level of diversity managed on farm. Finally, some suggestions are offered regarding further research needs in the field of modelling agrobiodiversity.