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Peripheral venous catheters: An underrecognized source of Staphylococcus aureus bacteremia

Published online by Cambridge University Press:  14 October 2022

Heather L. YoungOpen the ORCID record for Heather L. Young[Opens in a new window],
Deborah A. Aragon,
Lindsey Cella and
Kevin E. McVaney
Heather L. Young*
Affiliation:
Department of Medicine, Denver Health Medical Center and the University of Colorado School of Medicine, Denver, ColoradoDepartment of Patient Safety and Quality, Denver Health Medical Center, Denver, Colorado
Deborah A. Aragon
Affiliation:
Department of Patient Safety and Quality, Denver Health Medical Center, Denver, Colorado
Lindsey Cella
Affiliation:
Denver Health Paramedics, Denver, Colorado
Kevin E. McVaney
Affiliation:
Department of Emergency Medicine, Denver Health Medical Center and the University of Colorado School of Medicine, Denver, Colorado
*
Author for correspondence: Heather L. Young MD, E-mail: Heather.Young2@dhha.org
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Abstract

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Information

Type
Research Brief
Information
Infection Control & Hospital Epidemiology , Volume 44 , Issue 1 , January 2023, pp. 140 - 143
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Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America

Healthcare-associated Stapyhlococcus aureus bacteremia (SAB) has traditionally been caused by surgical-site infections or central-line–associated bloodstream infections. However, peripheral venous catheters (PVCs) are responsible for many cases of healthcare-associated SAB.

Previous authors have evaluated the impact of PVC bacteremia infections in case series Reference Trinh, Chan and Edwards1–Reference Austin, Sullivan, Whittier, Lowy and Uhlemann3 or case–control studies. Reference Blauw, Foxman, Wu, Rey, Kothari and Malani4 These researchers reported that PVC infections were more common in the antecubital site, in PVC present for ≥4 days, and in PVC placed in the emergency department or outside the institution. We assessed baseline rates of healthcare-associated SAB due to PVC and performed a case–control study to determine the risk factors for SAB due to PVC. We hypothesized that we would identify modifiable risk factors to improve the safety of patients with PVCs.

Methods

Setting and population

This retrospective, case–control study of adult patients was conducted at Denver Health Medical Center (DHMC). DHMC is a level 1 trauma center and an academic safety-net hospital with ∼500 beds. The study period spanned April 9, 2016, to March 31, 2021.

Data acquisition

Cases of SAB were identified by query of the electronic medical record data warehouse. Cases were classified as either community-onset SAB (≤2 days after hospitalization) or healthcare-associated SAB (ie ≥3 days after hospitalization or community-onset attributed to PVC removed in the 7 days prior). An infectious diseases physician reviewed cases of healthcare-associated SAB to determine the source using National Healthcare Safety Network definitions. 5 PVC-associated bacteremia was defined as an arterial or venous infection (VASC) with presence of PVC in that body site within the previous 7 days. Three controls were matched to each PVC-related SAB case based on the age of the patient (±5 years) and the date the PVC was placed (±3 days). Patients who were admitted for elective procedures, those who were admitted to psychiatry or obstetrics departments, and those who died within 2 days of PVC placement were excluded from the control set.

Data regarding the variables of interest were abstracted by a single reviewer via retrospective chart review. These data included age, sex, race, ethnicity, substance abuse, length of hospital stay, reason for hospital admission, and comorbid conditions (ie, diabetes mellitus, cirrhosis, end-stage renal disease, and an immunocompromised state defined as severe malnutrition, untreated cancer, or the current use of chemotherapy agents, biological modulators, or prednisone ≥20 mg per day for at least 1 month). Additional variables included the location of PVC insertion, body location of the PVC, size of PVC, skin antisepsis product, number of insertion attempts, days PVC was present, and phlebitis scale.

Peripheral IV standard of care

At DHMC, the Medical Action Industries IV Start Kit (Medical Action Industries, Arden, NC) is utilized. It contains a single chlorhexidine/isopropyl alcohol (CHG/IPA) swab. The DHMC vascular access team is a resource for difficult PVC placement, but most PVCs are placed by staff or supervised students. A maximum of 4 insertion attempts are permitted per individual, and ultrasound is available to trained personnel. The institutional policy is to remove a PVC placed by emergency medical services (EMS) and by outside facilities within 24 hours of hospitalization; the PVC site is not routinely changed if it was placed within the hospital.

Statistical analyses

Descriptive statistics were used to characterize the population. The χ2 test, Fisher exact test, or Wilcoxon rank-sum test was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) based on a significance level of P ≤ .05. The logistic regression model included variables with P ≤ .05 in the univariate analysis and those deemed to be potential confounders. The Hosmer-Lemeshow test and C-statistic were used to determine appropriateness of the model; adjusted odds ratios (ORs) with 95% confidence intervals (CIs) were used to report the effect of each variable on the outcome. This study was approved by the Colorado Multiple Institutions Review Board.

Results

Overall, 598 episodes of SAB in 559 patients occurred during the study period, and 542 cases were eligible for inclusion (17 were excluded due to age <18 years). Among these, 80 were hospital-onset SAB and 514 were community-onset SAB (Table 1). Of the community-onset SAB cases, 65 had accessed healthcare in the previous 7 days. SAB was more common in men (n = 274, 72.9%), and median patient age was 53.0 years (SD, 17.5). MRSA accounted for 31.9% of all SAB cases.

Table 1.

Demographic Data

a Units unless otherwise specified.

b Adjudicated using the National Healthcare Safety Network definitions.

Of the 80 hospital-onset SAB cases, PVC was the most common cause SAB (n = 24, 30.0%). Other common causes were pneumonia or lung infection (n = 18, 22.5%) and unknown source (n = 12, 15.0%). An additional 3 cases of PVC-associated SAB were detected among those who had accessed healthcare in the prior 7 days, and these were added to the case counts.

Compared to controls, the following factors caused PVC patients to be more likely to become infected: immunocompromised individuals (OR, 8.2; 95% CI, 2.0–34.2), PVCs placed by emergence medical services personnel (OR, 5.3, 95% CI, 1.4–19.4), and longer lengths of stay (OR, 1.1; 95% CI 1.1–1.2) (Table 2). Sex, PVC site, and duration of PVC were not associated with infection in multivariate analysis.

Table 2.

Risk Factors Associated With Peripheral Venous Catheter-Associated Bacteremia: Univariate and Multivariate Analyses

Note. OR, odds ratio; CI, confidence interval; SD, standard deviation.

a Units unless otherwise specified.

Discussion

Based on these findings, we focused initial quality efforts on EMS-placed PVCs and found opportunities for improvement. Nursing staff did not routinely remove externally placed PVCs because PVC placement location was not readily apparent. Nursing informatics modified the manager and bedside nurse dashboards to highlight externally placed PVCs. Additionally, PVCs in place for ≥24 hours became a standard metric that infection preventionists reported on the daily safety call.

We also evaluated EMS PVC placement technique. EMS PVC supplies included an alcohol swab, clear adhesive tape, tourniquet, macro/micro drip set or blood pump, 1,000-mL normal saline bag, and a PVC. The tape and tourniquets were stored in an open area and were used on multiple patients. Quality improvement efforts included introduction of sterile, single-use packages of CHG/IPA, semipermeable dressing, clear tape, tourniquet, extension tubing, and PVC.

Our initial evaluation of the postintervention data showed no infections in EMS-placed PVC, but there has been no decrease in overall PVC-related SAB. Previous researchers have described 4 mechanisms contributing to PVC infection: contamination along the catheter line where it inserts into the skin, contamination via the catheter hub, inoculation from a bloodstream infection, and inoculation from a contaminated infusate. Reference Zhang, Cao and Marsh6 Next, researchers at our institution will investigate these factors as we strive for better quality and safety for patients.

Our findings suggest that longer length of hospital stay, but not individual PVC durations, are associated with a higher risk of infection. Although PVC duration has been shown to be a risk factor for infection in other studies, the routine removal of PVC has not been associated with better outcomes. In fact, a randomized-controlled trial found that clinically indicated replacement of PVC has an equivalent infection risk to routine replacement. Reference Rickard, Webster and Wallis7 Clinically indicated replacement also has patient satisfaction benefits such as fewer needle sticks to patients in the hospital.

This study had several limitations. It had a single-center design and relatively small number of bloodstream infections. We focused our attention on SAB because it is a common, serious bloodstream infection often due to a break in the skin, but we did not evaluate bacteremia due to other pathogens because it would have been very difficult to determine the source of infection in many cases. The strengths of the study included a case–control design and the use of standardized NHSN definitions to determine the source of bacteremia.

In summary, our analyses identified EMS-related PVC and longer hospital durations as being associated with SAB. In addition to our EMS-specific interventions, we will address hand hygiene, hub-cleansing procedures, and catheter securement in the near future.

Acknowledgments

Financial support

No financial support was provided relevant to this article.

Conflicts of interest

All authors report no conflicts of interest relevant to this article.

References

Trinh, TT, Chan, PA, Edwards, O, et al. Peripheral venous catheter-related Staphylococcus aureus bacteremia. Infect Control Hosp Epidemiol 2011;32:579–583.CrossRefGoogle ScholarPubMed
Stuart, RL, Cameron, DR, Scott, C, et al. Peripheral intravenous catheter-associated Staphylococcus aureus bacteraemia: more than 5 years of prospective data from 2 tertiary health services. Med J Aust 2013;198:551–553.CrossRefGoogle ScholarPubMed
Austin, ED, Sullivan, SB, Whittier, S, Lowy, FD, Uhlemann, AC. Peripheral intravenous catheter placement is an underrecognized source of Staphylococcus aureus bloodstream infection. Open Forum Infect Dis 2016;3:ofw072.CrossRefGoogle ScholarPubMed
Blauw, M, Foxman, B, Wu, J, Rey, J, Kothari, N, Malani, AN. Risk factors and outcomes associated with hospital-onset peripheral intravenous catheter-associated Staphylococcus aureus bacteremia. Open Forum Infect Dis 2019;6:ofz111.CrossRefGoogle ScholarPubMed
National Healthcare Safety Network. CDC/NHSN surveillance definitions for specific types of infections. Centers for Disease Control and Prevention website. https://www.cdc.gov/nhsn/pdfs/pscmanual/17pscnosinfdef_current.pdf. Published 2021. Accessed August 17, 2022.Google Scholar
Zhang, L, Cao, S, Marsh, N, et al. Infection risks assocaited with peripheral vascular catheters. J Infect Prevent 2016;17:207–213.CrossRefGoogle Scholar
Rickard, CM, Webster, J, Wallis, MC, et al. Routine versus clinically indicated replacement of peripheral intravenous catheters: a randomised controlled equivalence trial. Lancet 2012;380:1066–1074.CrossRefGoogle ScholarPubMed
Figure 0

Table 1.Demographic Data

Figure 1

Table 2.Risk Factors Associated With Peripheral Venous Catheter-Associated Bacteremia: Univariate and Multivariate Analyses