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Improved sleep outcomes and next-day cognitive function in adults following clinical testing of a powder-based drink containing Mulberry leaf extract and a natural source of Tryptophan – ADDENDUM

Published online by Cambridge University Press:  13 September 2024

L. Owen ,
F. Pierre Martin ,
K. Mantantzis ,
S. Chun Siong ,
L. Tian ,
A. Cherta-Murillo ,
R. Thota ,
J. Jimenez Suarez ,
C. Ming  and
M. Boutant Lys
...Show all authors
L. Owen
Affiliation:
Nestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland
F. Pierre Martin
Affiliation:
Nestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland
K. Mantantzis
Affiliation:
Nestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland
S. Chun Siong
Affiliation:
Centre for Sleep and Cognition, Yong Loo Lin School of Medicine, National University of Singapore
L. Tian
Affiliation:
Centre for Sleep and Cognition, Yong Loo Lin School of Medicine, National University of Singapore
A. Cherta-Murillo
Affiliation:
Nestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland
R. Thota
Affiliation:
Nestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland
J. Jimenez Suarez
Affiliation:
Nestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland
C. Ming
Affiliation:
Nestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland
M. Boutant Lys
Affiliation:
Nestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland
G. Mun Teng Low
Affiliation:
Nestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland
M. Chee
Affiliation:
Centre for Sleep and Cognition, Yong Loo Lin School of Medicine, National University of Singapore
C. Darimont
Affiliation:
Nestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland
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Abstract

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Information

Type
Addendum
Information
Proceedings of the Nutrition Society , Volume 84 , Issue 4 , December 2025 , pp. 411
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Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of The Nutrition Society

Conclusions on the secondary outcomes of the abstract published in the Proceedings of the Nutrition Society were changed due to further analysis performed on the data. In our subsequent analysis, performance scores on the secondary outcomes sleep onset latency (subjective) mood and cognition were adjusted for baseline scores. Following adjustment, the findings are revised as such:

“The originally observed effects on sleep onset latency (subjective) is still significant but it is -3.09 mins; p=0.048. Cognitive performance endpoints were no longer significantly affected by treatment. Additionally, arousal was no longer significantly affected by treatment. However, treatment reduced the score on ‘Negative-Relaxed’ ratings (Brief Mood Introspection Scale; -0.4, p= .003), and improved the ‘Vigor-Activity’ rating (Profile of Mood Scale; +0.8,p=.038).”

The journal was alerted by the authors to this additional information on 21 March 2024, and the wording of the addendum was agreed and submitted on 7 June 2024.

References

Owen, L, Martin, FP, Mantantzis, K, et al. Improved sleep outcomes and next-day cognitive function in adults following clinical testing of a powder -based drink containing Mulberry leaf extract and a natural source of Tryptophan. Proceedings of the Nutrition Society. 2023;82(OCE5):E350. doi: 10.1017/S0029665123004494 CrossRefGoogle Scholar