Neurological soft signs (NSS) are minor (‘soft’) neurological abnormalities in sensory and motor performance identified by clinical examination. They have been described in excess in patients with schizophrenia (Reference Buchanan and HeinrichsBuchanan & Heinrichs, 1989). There is still a lack of consensus on the neurodysfunctional area underlying NSS; some authors suggest that NSS reflect a failure in the integration within or between sensory and motor systems (Reference Griffiths, Sigmundsson and TakeiGriffiths et al, 1998), whereas others advocate deficits in neuronal circuits involving subcortical structures (e.g. basal ganglia, brain-stem and limbic system; Reference Heinrichs and BuchananHeinrichs & Buchanan, 1988). Although the presence of NSS has been documented extensively in schizophrenia as a whole, the same cannot be said for patients undergoing their first psychotic episode. This review will briefly describe the NSS that have been commonly reported in patients with schizophrenia, and then concentrate on studies that have specifically investigated NSS at the time of the first psychotic episode.

NEUROLOGICAL SIGNS REPORTED IN SCHIZOPHRENIA

The majority of investigations into patients with schizophrenia at various stages of chronicity have described an excess of neurological ‘soft’ abnormalities. The term ‘soft’ was originally used, as opposed to ‘hard’, to reflect the absence of any obvious localised pathological lesion underlying these signs (Reference Tucker, Campion and KelleherTucker et al, 1974; Reference Quitkin, Rifkin and KleinQuitkin et al, 1976). This term has been employed, more recently, to indicate signs that do not reflect primary tract or nuclear pathology (Reference Woods, Kinney and Yurgelun-ToddWoods et al, 1986). Although the categorisation of neurological signs as ‘soft’ (e.g. frontal release and cerebellar signs) and the batteries used to measure them have varied, neurological abnormalities in schizophrenia seem to be localised to three main neurological domains: integrative sensory function; motor coordination; and motor sequencing (Table 1) (Reference Buchanan and HeinrichsBuchanan & Heinrichs, 1989). Deficits in integrative sensory function (possibly resulting from a parietal dysfunction) are reflected in higher rates of bilateral extinction, impaired audio—visual integration, agraphaesthesia and astereognosis (Reference Buchanan and HeinrichsBuchanan & Heinrichs, 1989; Reference Griffiths, Sigmundsson and TakeiGriffiths et al, 1998). Deficits in motor coordination have been reported through tests of general co-ordination, intention tremor, finger—thumb opposition, balance and gait. Finally, poor performance in complex motor tasks (possibly resulting from a dysfunction of the frontal—basal ganglial circuitry) has been reported in tests that involve repetitive alternating hand positions, such as the fist—edge—palm, the fist-ring and the Ozeretski tests.

Table 1

Functional areas frequently reported as abnormal in schizophrenia, and some of the tests that can elicit disturbances in these areas

Sensory integration	Motor coordination	Motor sequencing	Primitive reflexes
Audio—visual integration	Tandem walk	Fist-ring test	Gaze
Stereognosis	Rapid alternating movements	Fist—edge—palm test	Palmomental
Graphaestesia	Finger—thumb opposition	Oszeretski test	Snout
Extinction	Finger—nose test		Grasp
Right—left confusion	Rhythm tapping

Abnormalities have also been reported in eye movements (pursuit and saccadic movements; Reference Stevens, Henn and NasrallahStevens, 1982) and developmental reflexes (Reference Boks, Russo and KnegteringBoks et al, 2000), particularly in signs of frontal release. Other abnormalities, such as those of primary sensory function, have been less often described.

NEUROLOGICAL SOFT SIGNS IN FIRST-EPISODE PSYCHOSIS

Investigating patients at the early stages of the illness has the following potential advantages: it can clarify whether NSS are part of a neurodysfunction that underlies schizophrenia rather than the consequence of degenerative processes; and it can elucidate whether or not they are simply a neuroleptic-induced epiphenomenon (i.e. a consequence of long-term pharmacological treatment).

In considering patients with first-onset psychosis, it is important to note that some studies have included not just patients with schizophrenia but also those with other forms of psychosis. This over-inclusiveness is unavoidable as assessments are frequently performed at the very early stages of a psychotic presentation, when a diagnosis of definite schizophrenia may still be doubtful. Not including cases until they definitely qualify for a diagnosis of schizophrenia at a later stage would mean losing potential cases of schizophrenia from the initial sample. Therefore, for the purpose of this review, we will also include studies that have evaluated first-episode psychosis as a whole.

We decided to evaluate those studies that investigated neurological function in patients with first-episode psychosis using a clinical examination that specifically reported on the neurological function of this group of patients. We performed a Medline literature search of the period between 1966 and 2001 using the following terms: PSYCHIATRY and NEURO^*; SCHIZOPHRENIA and NEURO^*; FIRST EPISODE and NEURO^*; FIRST EPISODE and SOFT-SIGNS; SOFT-SIGNS and NSS. We also examined cross-references from the articles identified.

We identified nine studies, which are listed in Table 2.

Table 2

Studies included in this review, listed in alphabetical order

Reference	First-episode patients n	Diagnosis	Healthy controls n	High-risk subjects n	Evaluation scale
Reference Browne, Clarke and GervinBrowne et al, 2000	56	Schizophrenia/schizophreniform disorder	—	—	Neurological Evaluation Scale (Reference Buchanan and HeinrichsBuchanan & Heinrichs, 1989)
					Condensed Neurological Examination (Reference Rossi, De Cataldo and Di MicheleRossi et al, 1990)
Reference Carr, Halpin and LauCarr et al, 2000	56	Psychosis	—	60	Neurological Evaluation Scale (Reference Buchanan and HeinrichsBuchanan & Heinrichs, 1989)
Reference Flyckt, Sydow and BjerkenstedtFlyckt et al, 1999	21	Schizophrenia	55	—	Standard neurological examination
Reference Johnstone, Macmillan and FrithJohnstone et al, 1990	137	Schizophrenia	—	—	Neurological examination (adapted from Reference Quitkin, Rifkin and KleinQuitkin et al, 1976)
Reference Lawrie, Byrne and MillerLawrie et al, 2001	30	Schizophrenia	35	152	Neurological Evaluation Scale (Reference Buchanan and HeinrichsBuchanan & Heinrichs, 1989)
Reference Madsen, Vorstrup and RubinMadsen et al, 1999	341	Schizophrenia	20	—	Standard neurological examination
Reference Rubin, Vostrup and HemmingsenRubin et al, 1994	45	Schizophrenia/schizophreniform disorder	24	—	Standard neurological examination
Reference Sanders, Keshavan and SchoolerSanders et al, 1994	17	Schizophrenia/schizophreniform disorder	15	—	Neurological Evaluation Scale (Reference Buchanan and HeinrichsBuchanan & Heinrichs, 1989)
The Scottish Schizophrenia Research Group, 1987	49	Schizophrenia	—	—	Northwick Park Brief Neurological Assessment (Reference Cunningham Owens and JohnstoneCunningham Owens & Johnstone, 1980)

First-episode studies of NSS can be divided into: (a) studies that have evaluated the prevalence of NSS among patients with first-episode psychosis only (i.e. without including a comparison group); (b) studies that have evaluated NSS in first-episode patients and compared them with healthy controls; (c) studies that have compared first-episode patients with subjects at high risk of developing psychosis; and finally, (d) studies that have evaluated NSS at first-episode and then at follow-up. Unfortunately, a variety of instruments have been used to evaluate neurological function, and not all studies have used a published, validated instrument, often reporting on findings derived from a ‘clinical neurological assessment’, which makes comparison of the results difficult (Table 2).

NEUROLOGICAL SOFT SIGNS AND FAMILIALITY

Therefore, investigators have studied the relationship between NSS and genetic vulnerability to this illness. An excess of NSS (especially of integrative signs) has been reported in patients with a positive family history for schizophrenia, in comparison with those without such a history (Reference Walker and ShayeWalker & Shaye, 1982; Reference Griffiths, Sigmundsson and TakeiGriffiths et al, 1998), and indeed healthy relatives of patients with schizophrenia (Reference Griffiths, Sigmundsson and TakeiGriffiths et al, 1998; Reference Ismail, Cantor-Graae and McNeilIsmail et al, 1998; Reference Niethammer, Weisbrod and SchiesserNiethammer et al, 2000).

The majority of the first-episode studies reviewed did not evaluate the relationship between neurological function and familiality. Three studies (Reference Flyckt, Sydow and BjerkenstedtFlyckt et al, 1999; Reference Madsen, Vorstrup and RubinMadsen et al, 1999; Reference Lawrie, Byrne and MillerLawrie et al, 2001) evaluated family history or genetic loading and neurological function and reported no association between prevalence of NSS and family history. However, a relationship was reported between family history and a specific laterality pattern in psychomotor performance in one study (Reference Flyckt, Sydow and BjerkenstedtFlyckt et al, 1999), and family history and progression of neurological dysfunction in another (Reference Madsen, Vorstrup and RubinMadsen et al, 1999).

In the study by Madsen et al (Reference Madsen, Vorstrup and Rubin1999), information was obtained on psychiatric disorders in the first- and second-degree relatives. Although there was no association between a positive family history of psychosis and NSS at first presentation, the patients with a history of psychotic disorder in first-degree relatives showed a significant neurological deterioration at follow-up.

The report of no association between positive family history and neurological dysfunction in these first-episode studies is in contrast with previous observation of a relationship between the two reported in patients at various illness stages. However, it is possible that, if a positive family history is associated with more progression in neurological dysfunction, studies of patients in more advanced stages of schizophrenia could have had more chances of identifying this association, less evident in the initial stages of the illness. It is, however, difficult to draw a conclusion from the few studies reported.

LATERALITY AND CEREBRAL DOMINANCE

To date, research has not identified an unequivocal laterality pattern of neurological signs in schizophrenia in general (and by implication a lesion of a particular hemisphere). Some studies have reported a predominance of neurological abnormalities on the right side of the body (Reference TorreyTorrey, 1980; Reference Caligiuri and LohrCaligiuri & Lohr, 1994), but there are conflicting reports of higher scores for NSS on the left side of the body (Reference Niethammer, Weisbrod and SchiesserNiethammer et al, 2000).

The first-onset study of Browne et al (Reference Browne, Clarke and Gervin2000) evaluated the relationship of mixed-handedness (measured with the Edinburgh Inventory; Reference OldfieldOldfield, 1971) to NSS. In the Edinburgh Inventory, subjects are asked to perform 10 common activities and a laterality quotient is then calculated. The authors reported that narrowly defined mixed-handed subjects (two or more discrepancies in hand preference) performed worse on both the NES and the CNE examinations, in comparison with lateralised individuals. Although the number of mixed-handed subjects was small, this raises the possibility that individuals whose handedness is not lateralised have poorer motor coordination than those with a lateralised hand preference. This finding should be interpreted along with the reported excess of mixed-handedness in patients with psychosis, and especially with schizophrenia (Reference Cannon, Byrne and CassidyCannon et al, 1995; Reference Malesu, Cannon and JonesMalesu et al, 1996; Reference Orr, Cannon and GilvarryOrr et al, 1999).

Mixed-handedness in schizophrenia has been postulated by Crow (Reference Crow1997) to reflect an abnormality of cerebral dominance. Possible relevant information comes from our preliminary report (Reference Dazzan, Morgan and OrrDazzan et al, 2001) of a worse neurological performance (especially for coordination and sequencing) on the left side of the body in a group of 145 subjects with first-episode psychosis. A common neurodevelopmental fault can underlie both the excess of mixed-handedness in schizophrenia and that of an abnormal neurological function (possibly lateralised to one side of the body), which was particularly marked in these subjects.

The study by Flyckt et al (Reference Flyckt, Sydow and Bjerkenstedt1999) evaluated both patients with schizophrenia (some at first-episode and some in more advanced stages) and their parents. There were no differences in NSS between patients positive or negative for family history. However, probands and relatives were also asked to perform the finger-tapping test, a test of psychomotor performance. A significant difference was observed in the laterality pattern of patients and parents who were family-history positive, compared with patients and parents who were family-history negative. More specifically, in this test, patients and parents who were family-history positive improved their performance with the preferred hand, whereas the family-history negative parents neither significantly improved nor decreased their performance with the preferred hand over time. Considering that the finger-tapping test can provide information on cerebral laterality (Reference Gorynia and UebelhackGorynia & Uebelhack, 1992), and that an abnormal pattern of hemispheric asymmetry has been reported in families multiply affected by schizophrenia (Reference Sharma, Lancaster and SigmundssonSharma et al, 1999), it is possible that the association between family history and a specific laterality pattern could reflect an inherited predisposition to this illness.

ROLE OF ANTIPSYCHOTIC MEDICATION IN NEUROLOGICAL PERFORMANCE

Could side-effects of antipsychotic medication in general, and tardive dyskinesia in particular, explain the excess of NSS in subjects with psychosis? No association between past and current neuroleptic exposure and presence of NSS has been found (Reference Ismail, Cantor-Graae and McNeilIsmail et al, 1998). Indeed, most studies have failed to find any association between tardive dyskinesia and NSS (Reference Wegner, Catalano and GibralterWegner et al, 1985; Reference King, Wilson and CooperKing et al, 1991; Reference Mohr, Hubmann and CohenMohr et al, 1996). In an attempt to control for the possible contribution of neuroleptic medication to NSS, scales for extrapyramidal symptoms, akathisia and tardive dyskinesia have been used in studies of NSS; results have shown that these neurological abnormalities cannot be simply considered a medication effect (Reference Griffiths, Sigmundsson and TakeiGriffiths et al, 1998).

However, more definitive information on the effect of antipsychotics on neurological function can be obtained by studying neuroleptic-naïve subjects who have never been exposed to pharmacological treatment, or subjects at their first psychotic episode, who have not been exposed to long-term pharmacological treatment.

Studies on neuroleptic-naïve first-episode patients consistently report higher NSS rates in these subjects than in healthy controls. Madsen et al (Reference Madsen, Vorstrup and Rubin1999) compared neuroleptic-naïve subjects with first-episode schizophrenia or schizophreniform disorder with healthy control subjects; neuroleptic-naïve patients showed significantly higher rates of neurological abnormalities than controls. Flyckt et al (Reference Flyckt, Sydow and Bjerkenstedt1999) examined first-episode and chronic patients together. There were no differences in NSS between medicated and non-medicated subjects, except for facial expression. There was no correlation between NSS and either the daily dosage of medication or the length of treatment.

Browne et al (Reference Browne, Clarke and Gervin2000) reported that the rates of NSS did not differ significantly in neuroleptic-naïve or neuroleptic-treated patients, with 97.1% of neuroleptic-naïve subjects with psychosis showing at least one neurological sign. This rate is much higher than the rate reported from other studies (Reference Gupta, Andreasen and ArndtGupta et al, 1995), and could have been related to differences in the sensitivity of the assessment and the scoring guidelines used. For example, in the study by Gupta et al (Reference Gupta, Andreasen and Arndt1995) the assessment did not include signs of frontal lobe dysfunction, which are considered the tests most likely to identify the motor disturbance present in schizophrenia (Reference Manschreck, Maher and AderManschreck et al, 1981). This is also supported by the findings of Cuesta et al (Reference Cuesta, Peralta and de Leon1996), who evaluated frontal signs through motor coordination and sequencing of complex motor tasks and reported rates of NSS in neuroleptic-naïve patients as high as those of Browne and colleagues.

Indirect evidence that NSS are not related to neuroleptic treatment also comes from the study of Lawrie et al (Reference Lawrie, Byrne and Miller2001). They reported how the excess of sensory integration signs was similar in both first-episode patients and high-risk subjects, and significantly higher than in healthy controls, suggesting that NSS represent a neurodevelopmental risk factor for schizophrenia rather than being the consequence of having been exposed to neuroleptic treatment.

Surprisingly, some authors have proposed a hypothetical protective effect of antipsychotics on neurological dysfunction. For example, in the follow-up study by Madsen et al (Reference Madsen, Vorstrup and Rubin1999), there was an increase in NSS in patients with schizophrenia 5 years after their first present ation; this increase was more marked in those patients who had been free of medication for the time of the entire follow-up. Signs related to the corticospinal tract were over-represented. The authors reported how the neuroleptic load in non-responder patients was inversely related to change in total neurological abnormalities. It is also possible that the positive effect observed is related to the efficacy of antipsychotics on the clinical presentation.

Thus, first-episode studies demonstrate that the neurological dysfunction observed could not be interpreted as the consequence of neuroleptic medication, and one study suggests that antipsychotics may, directly or indirectly, improve the baseline neurological dysfunction. However, it is important that future studies addressing this issue include in their battery signs of frontal lobe dysfunction, because these best reflect the motor abnormalities typical of schizophrenia, rather than those related to neuroleptic use.

NEUROLOGICAL SOFT SIGNS AND DEMOGRAPHIC CHARACTERISTICS

Studies of patients at various stages of schizophrenia other than at first-episode have generally failed to report any consistent association between neurological abnormalities and socio-demographic characteristics of patients (Reference Ismail, Cantor-Graae and McNeilIsmail et al, 1998). However, there have been isolated reports of NSS being increased especially in male patients with schizophrenia (Reference Heinrichs and BuchananHeinrichs & Buchanan, 1988), or more dependent on age and duration of illness (Reference Lane, Colgan and MoynihanLane et al, 1996; Reference Blyler, Maher and ManschreckBlyler et al, 1997; Reference Malla, Norman and AguilarMalla et al, 1997). When trying to disentangle whether these associations are part of the underlying aetiopathological process, or simply its epiphenomena, it is important to control for these variables.

The studies of patients with first-episode psychosis reviewed here reported no relationship between the presence of NSS and age (Reference Sanders, Keshavan and SchoolerSanders et al, 1994), but possible relationships have been reported with male gender (The Scottish Schizophrenia Research Group, 1987; Reference Madsen, Vorstrup and RubinMadsen et al, 1999), lower education (Reference Rubin, Vostrup and HemmingsenRubin et al, 1994; Reference Browne, Clarke and GervinBrowne et al, 2000), and lower socio-occupational outcome (Reference Johnstone, Macmillan and FrithJohnstone et al, 1990).

Male patients were described as having a significant increase in the number of neurological abnormalities 5 years after onset in a follow-up study by Madsen et al (Reference Madsen, Vorstrup and Rubin1999). In this sample, males were also more likely to have been subjected to maternal obstetric complications and a non-remitting course of the illness. In the Scottish Schizophrenia Research Group's study (1987), most of the non-responders were males with neurological impairment. It is possible that the excess of neurological abnormalities in male patients, together with an increased risk of neuro-developmental damage and of a generally more severe illness (Reference Castle and MurrayCastle & Murray, 1991; Reference Bullmore, Brammer and HarveyBullmore et al, 1995), is part of a greater vulnerability of the developing male brain to environmental insults (Reference MurrayMurray, 1994).

The presence of a neurodevelopmental abnormality may also explain the reported association between lower educational achievement and higher rates of NSS in first-episode studies (Reference Rubin, Vostrup and HemmingsenRubin et al, 1994). However, the evidence derived from the study by Browne et al (Reference Browne, Clarke and Gervin2000) is indirect. In fact, in their study a significant difference in years of education was present between mixed-handed and lateralised patients, with the mixed-handed patients having a significantly lower number of years of completed education. As mixed-handed patients showed more neurological abnormalities, the authors speculated that neurological abnormalities were also associated with lower years of education. These results should be interpreted cautiously; it is likely that patients with more severe forms of the disease, and with higher rates of neurological abnormalities, would have found it more difficult to continue their education.

Nevertheless, the above results are consonant with evidence of an association between IQ and neurological abnormalities, specifically between IQ and signs of sensory integration (Reference KennardKennard, 1960; Reference Mosher, Pollin and StabenauMosher et al, 1971; Reference Arango, Bartko and GoldArango et al, 1999). It has been suggested that the concomitant presence of NSS and cognitive deficits in schizophrenia could reflect a diffuse, generalised brain disorder (Reference Kolakowska, Williams and JamborKolakowska et al, 1985; Reference King, Wilson and CooperKing et al, 1991; Reference Flashman, Flaum and GuptaFlashman et al, 1996). The line between some NSS and selected neuropsychological tests is often difficult to draw: evaluating these together could provide comprehensive information on a range of regional neurological dysfunctions. Even just IQ, which has been extensively evaluated in previous studies, has not been frequently examined in first-episode studies on NSS.

NEUROLOGICAL SOFT SIGNS AND BRAIN STRUCTURAL ABNORMALITIES

Clarifying the relationship between brain structure and neurological dysfunction could point to the anatomical substrates of NSS present in schizophrenia. Unfortunately, only a few studies of chronic patients have examined this relationship. The presence of NSS has been associated with an enlargement of cerebral ventricles (Reference Weinberger, Wyatt and UsdinWeinberger & Wyatt, 1982), and with smaller brain areas (Reference DeMyer, Gilmor and HendrieDeMyer et al, 1988), whereas no correlation has been found between NSS and the calculated ratio between the width of the ventricles and the brain (Reference Kolakowska, Williams and JamborKolakowska et al, 1985).

Among first-episode studies, the only one that evaluated this relationship was the computerised tomography (CT) study by Rubin et al (Reference Rubin, Vostrup and Hemmingsen1994). This study reported an association between NSS and shorter brain length and wider left Sylvian fissure, together with a tendency for patients with more neurological abnormalities to have smaller brain volume, more cerebrospinal fluid in the sulci and cisterna on the brain surface, increased width of the right Sylvian fissure and smaller temporal horn volume. As in previous studies (Reference Kolakowska, Williams and JamborKolakowska et al, 1985), there was no indication that NSS were associated with greater volume of lateral ventricles. The findings of this study suggest that neurological abnormalities could be associated with cortical rather than subcortical lesions. More studies with large samples, investigating the anatomical correlates of neurological signs specifically selected to explore regional function/dysfunction, are needed before firm conclusions can be drawn.

RELATIONSHIP BETWEEN NSS AND THE PSYCHOPATHOLOGY AND COURSE OF SCHIZOPHRENIA

Previous studies on patients at different stages of their illness have asked whether neurological abnormalities are associated with a specific symptom profile or course of the schizophrenic illness. Some studies have reported a relationship between NSS and different subtypes of schizophrenia, such as chronic v. acute schizophrenia (Reference TorreyTorrey, 1980) and disorganised v. non-disorganised schizophrenia (Reference Schroder, Niethammer and GeiderSchroder et al, 1991). Neurological abnormalities have also been associated with total number of psychiatric symptoms (Reference Tucker, Silberfarb, Akiskal and WebbTucker & Silberfarb, 1978), thought disorder (Tucker et al, Reference Tucker, Campion and Kelleher1974, Reference Tucker, Campion and Silberfarb1975; Manschreck et al, Reference Manschreck, Maher and Ader1981, Reference Manschreck, Maher and Rucklos1982), negative symptoms (Reference Caligiuri and LohrCaligiuri & Lohr, 1994; Reference Wong, Voruganti and HeslegraveWong et al, 1997) and emotional stability (Reference Quitkin, Rifkin and KleinQuitkin et al, 1976). By contrast, other studies have found no association between NSS and positive symptoms (Reference Kolakowska, Williams and JamborKolakowska et al, 1985), or paranoid/non-paranoid schizophrenia (Reference Manschreck and AmesManschreck & Ames, 1984).

Similar conflicting results have also characterised studies that evaluated the relationship between psychopathology and NSS in first-episode psychosis. For example, Browne et al (Reference Browne, Clarke and Gervin2000) described an association between NSS and total symptom severity and positive symptoms whereas others have reported no association with global measures of psychopathology (Reference Sanders, Keshavan and SchoolerSanders et al, 1994), or with positive and negative dimensions of schizophrenia (Reference Flyckt, Sydow and BjerkenstedtFlyckt et al, 1999). A possible reason for the inconsistency of these results lies in the different scale used to measure NSS. For example, Flyckt et al (Reference Flyckt, Sydow and Bjerkenstedt1999) did not use a scale that included factors involving attention and initiative. As Browne et al (Reference Browne, Clarke and Gervin2000) suggested, the correlation between total NSS and positive symptoms may reflect attentional deficits secondary to untreated symptoms. Not only is the number of first-episode studies small, but some studies also lacked sufficient power to evaluate such associations.

The potential association between the presence of neurological signs and a more chronic and severe form of the illness has also been investigated by studies on patients at different stages of the illness. This has been supported by the association of NSS with young age at onset (Reference TorreyTorrey, 1980), a more chronic course (Reference TorreyTorrey, 1980), longer index hospitalisation (Reference Rochford, Detre and TuckerRochford et al, 1970) and impaired premorbid functioning (Reference Quitkin, Rifkin and KleinQuitkin et al, 1976; Reference Kolakowska, Williams and JamborKolakowska et al, 1985). However, some of these findings have not been corroborated by other studies, in which no association was found with age at onset (Reference Kolakowska, Williams and JamborKolakowska et al, 1985), poor premorbid functioning (Reference TorreyTorrey, 1980; Reference Kolakowska, Williams and JamborKolakowska et al, 1985), number of total hospitalisations in a 3-year follow-up (Reference Tucker, Silberfarb, Akiskal and WebbTucker & Silberfarb, 1978) and lifetime hospitalisations (Reference Mosher, Pollin and StabenauMosher et al, 1971).

The majority of first-episode studies report no correlation between NSS and age at onset (Reference Madsen, Vorstrup and RubinMadsen et al, 1999), duration of untreated psychosis (Madson et al, 1999; Reference Browne, Clarke and GervinBrowne et al, 2000), global assessment of functioning (Reference Sanders, Keshavan and SchoolerSanders et al, 1994), and occupational outcome (Reference Johnstone, Macmillan and FrithJohnstone et al, 1990). It is possible that factors such as occupational outcome and global assessment of functioning are worse in more advanced phases of the illness, and are therefore not associated with neurological dysfunction in the initial stages. However, two studies described an association between NSS and both poorer premorbid social adjustment (Reference Browne, Clarke and GervinBrowne et al, 2000) and number of in-patient days (Reference Johnstone, Macmillan and FrithJohnstone et al, 1990). These associations could be related to the fact that higher rates of signs are part of a more severe clinical picture, which could for example explain the longer time spent in hospital; it is also possible that this is reflected in longer pharmacological treatment, which could in turn give rise to more NSS.

In conclusion, the studies reviewed confirm that an excess of NSS is already evident in patients suffering their first-episode of schizophrenia or psychosis, and indeed in high-risk subjects without psychosis. Neurological performance appears to be worse in the areas of motor coordination and sequencing, in sensory integration and in developmental reflexes. These minor neurological anomalies are found particularly in males and in subjects with lower education, and possibly in those with a more severe clinical picture. The presence of neurological abnormalities cannot be explained away as a consequence of neuroleptic use, although higher NSS scores are observed in those first-episode subjects on neuroleptic treatment. For an optimal differentiation of the motor disturbance typical of schizophrenia from the side-effects of neuroleptic treatment, it is important that signs of frontal lobe dysfunction are included in the assessment.

First-episode studies also support an association between neurological signs and a specific pattern of laternality, as suggested by their particular excess in mixed-handed subjects, and by some preliminary reports of their lateralisation to one side of the body. This abnormal laterality pattern in psychomotor performance is more frequently accompanied by a positive family history of psychosis, and is present in relatives without psychosis that are positive for family history. It is possible that this could be related to the evidence that, as part of the genetic vulnerability to develop schizophrenia, the cerebral hemispheres develop less asymmetrically. These findings support the notion that neurological signs mainly result from a genetic vulnerability rather than neurodegeneration, or the consequences of the illness (pharmacological treatment, institutionalisation). Future studies should therefore attempt to identify whether any NSS is specific and discriminative of schizophrenia, as opposed to other psychiatric disorders.

CLINICAL IMPLICATIONS

1. ▪ A neurological dysfunction is already evident in patients having their first-episode of schizophrenia or psychosis, and is not the result of illness progression.

2. ▪ The presence of neurological abnormalities in schizophrenia cannot be explained away as a consequence of neuroleptic use.

3. ▪ The presence of a neurological dysfunction in schizophrenia may contribute to identifying subjects at risk of a poor prognosis, who may benefit from early intervention.

LIMITATIONS

1. ▪ The number of studies investigating neurological performance in first-episode psychosis is still small.

2. ▪ A variety of instruments have been used to evaluate neurological function, and this makes comparison of the results difficult.

3. ▪ The majority of first-episode psychosis studies did not investigate neurological performance separately for the two sides of the body, hampering the understanding of the role of lateralisation in neurological dysfunction.