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Greenhouse gas emissions due to unnecessary antibiotic prescriptions

Published online by Cambridge University Press:  04 September 2024

Emily S. SpivakOpen the ORCID record for Emily S. Spivak[Opens in a new window],
Jessica TobinOpen the ORCID record for Jessica Tobin[Opens in a new window],
Adam L. Hersh and
Alexis P. Lee
Emily S. Spivak*
Affiliation:
Division of Infectious Diseases, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA
Jessica Tobin
Affiliation:
University of Utah School of Medicine, Salt Lake City, UT, USA
Adam L. Hersh
Affiliation:
Division of Infectious Diseases, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA
Alexis P. Lee
Affiliation:
Environmental and Social Sustainability, University of Utah Health, Salt Lake City, UT, USA
*
Corresponding author: Emily S. Spivak; Email: Emily.spivak@hsc.utah.edu

Abstract

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Information

Type
Research Brief
Information
Antimicrobial Stewardship & Healthcare Epidemiology , Volume 4 , Issue 1 , 2024, e114
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America

Introduction

The climate crisis has been called the greatest threat to health of the 21st century. Healthcare accounts for 8.5% of total US greenhouse gas emissions, Reference Eckelman, Huang, Lagasse, Senay, Dubrow and Sherman1 and the US healthcare system contributes more to global greenhouse gas emissions than any other healthcare system worldwide. Reference Eckelman and Sherman2 Pharmaceuticals account for 10% of total healthcare emissions in the United States, Reference Eckelman and Sherman2 with the carbon footprint across various stages of healthcare categorized into three scopes. Scope 3 includes all healthcare-related indirect emissions across fifteen categories, one of which is indirect emissions associated with the production and distribution of pharmaceuticals. Reference Eckelman and Sherman2 Overall, pharmaceuticals account for approximately 18% of scope 3 emissions. Reference Eckelman and Sherman2 One potential strategy to mitigate harmful emissions is to measure emissions encompassed in Scope 3 in the form of waste associated with medications lacking a clear indication.

30%–50% of antibiotic use across US healthcare is unnecessary. Reference Hersh, King, Shapiro, Hicks and Fleming-Dutra3 Antibiotic Stewardship encompasses efforts to measure and improve antibiotic prescribing with the goal of minimizing unintended consequences of unnecessary antibiotic prescribing. Antibiotic stewardship commonly focuses on development of diagnostic and treatment pathways, education, antibiotic restrictions, and provider feedback. Quantifying antibiotic-associated greenhouse gas emissions may be another tool for antibiotic stewardship to influence prescribing. We aimed to measure the greenhouse gas emissions from waste associated with unnecessary antibiotic prescriptions in the United States (US).

Methods

We obtained sample waste from an outpatient antibiotic prescription from the University of Utah Outpatient Pharmacy including a paper bag, paper leaflet insert, and plastic prescription bottle. We calculated emissions for the waste based on the weight of each item using the US Environmental Protection Agency (EPA) greenhouse gas emission factors. 4 Waste emissions are calculated by multiplying the total mass of each item by the appropriate emission factor depending on the waste type (eg, paper or plastic) and waste treatment method which we assumed to be landfilled.

We calculated unnecessary antibiotic prescriptions based on the estimated percent of unnecessary antibiotic prescriptions (28%) in 2014–2015 multiplied by the number of prescriptions in the US in 2022. Reference Hersh, King, Shapiro, Hicks and Fleming-Dutra3,5 Waste emissions of an individual prescription were multiplied by the number of unnecessary antibiotic prescriptions to arrive at a total landfilled waste emissions. We used the EPA’s Greenhouse Gas Equivalencies Calculator to convert emissions into concrete greenhouse gas equivalents that providers and patients can understand. 6

Results

An individual prescription has 32g of paper waste (paper bag 10g and leaflet 22g) and 15g of plastic bottle waste. Based on published estimates, there were 236,100,000 antibiotic prescriptions (Table 1) in the US in 2022, with 66,108,000 of them likely unnecessary. Reference Hersh, King, Shapiro, Hicks and Fleming-Dutra3 Our estimates suggest these prescriptions led to 1887.374 CO2e/ton of greenhouse gas emissions, the same as driving 4,838,375 miles by an average gasoline-powered vehicle, or 194.3 times around the equatorial circumference of the Earth.

Table 1.

Estimates of waste emissions due to unnecessary outpatient antibiotic prescriptions in the US, 2014–2015

a Weight of paper leaflet = 22g; weight of paper bag = 10 g.

b Emissions factor of 0.80.

c Weight of plastic bottle = 15g.

d Emissions factor of 0.02.

Discussion

To our knowledge, this is the first evaluation of the impact of unnecessary antibiotics in humans on greenhouse gas emissions, and we estimated annual unnecessary outpatient antibiotic prescriptions contribute the same emissions as driving an average gas-powered car around the Earth 194.3 times.

Our analysis likely significantly underestimates emissions due to our ability to only estimate solid waste associated with antibiotic prescriptions; notably excluding emissions from upstream production and transportation of antibiotics that would be included in scope 3. We also did not account for patients who may refuse packaging or use paper and/or plastic recycling. However, even with these limitations, estimates of annual scope 3 outpatient antibiotic waste emissions are immense.

There are numerous examples of low-value care in medicine, defined by patient clinical outcomes and cost; however, when adding possible environmental impacts, we contend these practices become even less valuable and arguably detrimental to society. Traditional stewardship strategies have limited impact on certain providers and patients, and we believe incorporating data on environmental waste and contributions to greenhouse gas emissions from unnecessary antibiotics could only strengthen antibiotic stewardship efforts and inform public health policy.

Acknowledgments

The authors would like to thank the University of Utah Outpatient Pharmacy for supplying a sample prescription.

Financial support

None reported.

Competing interests

All authors report no conflicts of interest relevant to this article.

References

Eckelman, MJ, Huang, K, Lagasse, R, Senay, E, Dubrow, R, Sherman, JD. Health care pollution and public health damage in the United States: an update. Health Aff (Millwood) 2020;39:2071–2079.CrossRefGoogle Scholar
Eckelman, MJ, Sherman, J. Environmental impacts of the U.S. health care system and effects on public health. PLoS One 2016;11:e0157014.CrossRefGoogle ScholarPubMed
Hersh, AL, King, LM, Shapiro, DJ, Hicks, LA, Fleming-Dutra, KE. Unnecessary antibiotic prescribing in US ambulatory care settings, 2010-2015. Clin Infect Dis 2021;72:133–137.Google ScholarPubMed
Scope 3 GHG Emissions Accounting Tool. Health Care Emissions Impact Calculator. https://practicegreenhealth.org/tools-and-resources/health-care-emissions-impact-calculator. Accessed February 6, 2024.Google Scholar
Outpatient Antibiotic Prescriptions — United States, 2022. https://www.cdc.gov/antibiotic-use/data/report-2022.html. Accessed February 6, 2024.Google Scholar
Greenhouse Gas Equivalencies Calculator. Convert emissions or energy data into concrete terms you can understand — such as the annual CO2 emissions of cars, households, and power plants. https://www.epa.gov/energy/greenhouse-gas-equivalencies-calculator. Accessed February 2, 2024.Google Scholar
Figure 0

Table 1.Estimates of waste emissions due to unnecessary outpatient antibiotic prescriptions in the US, 2014–2015