Case report
A 3-month-old boy who weighed 6.0 kg was admitted to our hospital with a fever, poor feeding, and a lack of activity. The infant was diagnosed with acute urinary tract infection and was started on intravenous fluid and antibacterial therapy. He had no family history of kidney or cardiac diseases. On the 4th day of hospitalisation, we noticed oedema of the extremities, palpable liver 2.5 cm below the right costal rim, and palpable bilateral kidneys on the back. Vital signs were as follows: temperature, 38.9°C; heart rate, 142 bpm; blood pressure, 128/78 mmHg; and oxygen saturation, 99%. Levine I/VI systolic murmur and gallop rhythm were observed at the left margin of the 4th intercostal sternum. A clinical image of the patient upon admission is shown in Figure 1 (Fig. 1a–e). Chest radiography revealed cardiac enlargement. An electrocardiogram showed sinus tachycardia; the ST was depressed in V3-6, and the R wave was poorly increased in V5-6. Echocardiography revealed an enlarged left ventricular end-diastolic diameter and decreased left ventricular ejection fraction (LVEF). Abdominal ultrasonography revealed bilateral renal enlargement, numerous cysts in the kidney, and mosaic-like and coarse hepatic parenchyma. Laboratory findings are presented in Figure 2. Blood test results showed an elevated B-type natriuretic peptide level (4104 pg/mL), a slightly elevated creatinine level (0.32 mg/dL), and a decreased estimated glomerular filtration rate (60 mL/min/m2). Both blood and urine cultures were positive for Escherichia coli. Based on these findings, we diagnosed the patient with heart failure due to hypertensive cardiomyopathy (HTN-CM), autosomal recessive polycystic kidney disease (ARPKD), renal hypertension, renal anaemia, urinary tract infection, and congenital liver fibrosis. PKHD1 gene analysis revealed two compound heterozygous mutations: c.5912G > C and c.1690C > T.
( a ) Chest radiography on admission showing cardiac enlargement. ( b ) Electrocardiogram at rest on admission showing sinus tachycardia; the ST is depressed in V3-6, and the R wave is poorly increased in V5-6. ( c ) Echocardiography on admission showing a dilatation of left ventricular end-diastolic diameter (44 mm), noticeably decreased left ventricular ejection fraction (16%), and mild mitral regurgitation. ( d ) Abdominal ultrasound on admission showing bilateral enlargement of the kidneys and numerous small cysts in kidneys. The hepatic parenchyma is mosaic-like and coarse. Share wave elastography showing increased liver stiffness. ( e ) Clinical course of the patient.
Laboratory data on admission. WBC = white blood cell; RBC = red blood cell; NAG = N-acetyl-β-D-glucosaminidase; β2 MG = β2 macroglobulin; VMA = vanillylmanderic acid; HMA = homovanillic acid; AST = aspartate aminotransferase; ALT = alanine aminotransferase; T-bil = total bilirubin; CK = creatinine kinase; BUN = blood urea nitrogen; CRP = C-reactive protein.
ARPKD-associated renal hypertension was believed to cause dilated cardiomyopathy (DCM)-like HTN-CM. The treatment consisted mainly of antihypertensive and anti-heart failure therapies. Azilsartan and clonidine hydrochloride were started as antihypertensive therapies with the aim of lowering systolic blood pressure to approximately 100 mmHg, and amlodipine besylate was used as an abortive dose when it was difficult to manage the patient. In the acute phase, dobutamine hydrochloride, olprinone hydrochloride hydrate, and diuretics, including furosemide, spironolactone, and tolvaptan, were used as anti-heart failure therapies, whereas bisoprolol fumarate was started on the 20th day of hospitalisation to slow the heart rate and suppress remodelling. Chest radiography showed improvement in cardiac enlargement, B-type natriuretic peptide level decreased to 10.3 pg/mL, and LVEF improved to 40% (Fig. 3a,b). The patient was discharged on the 131st day.
( a ) Chest radiography on discharge. ( b ) Echocardiography on discharge.
Discussion
Although children with ARPKD develop concentric left ventricular hypertrophy (LVH) in a significant proportion of cases, no cases of DCM-like HTN-CM in infants have been reported worldwide. Furthermore, previous evidence from rat models of ARPKD has shown a significant temporal relationship between cyst development, hypertension, and LVH. Reference Phillips, Hopwood and Loxley1–Reference Lucchetti, Chinali, Emma and Massella3 HTN-CM is often associated with primary histological and functional impairment of the myocardium and damage to other organs, such as blood vessels and kidneys. Almost all cases of ARPKD are complicated by hypertension; however, the onset varies from case to case, and the mechanism of hypertension in ARPKD remains unclear. Reference Hartung and Guay-Woodford4 As remodelling progresses owing to hypertension, the myocardium becomes concentric hypertrophied and shows LVH, resulting in heart failure and decreased diastolic function. More severe and prolonged hypertension leads to centrifugal hypertrophy of the myocardium, and progression to DCM-like HTN-CM decreases systolic function. Reference Ganau, Devereux and Roman5 Therefore, in this case, we believe that severe and prolonged hypertension caused by ARPKD in the early postnatal period led to myocardial remodelling.
Because low-output cardiomyopathy, as in this case, can cause sudden death triggered by infection or other causes, caution should be exercised. ARPKD cysts are difficult to diagnose using fetal echocardiography until the 30th week of life. We hope that the fetal diagnostic rate for ARPKD will improve with the development of fetal echocardiography. To prevent the development of heart failure in patients with HTN-CM due to ARPKD, it is important to improve the fetal diagnosis rate of ARPKD, detect hypertension early, and strictly control the blood pressure after birth.
