Treating tobacco dependence is paramount for global tobacco control efforts, but is often overshadowed by other policy priorities. As stated by Jha (Reference Jha2009), “cessation by current smokers is the only practical way to avoid a substantial proportion of tobacco deaths worldwide before 2050.” Its importance is codified in Article 14 of the Framework Convention on Tobacco Control (FCTC), and in the WHO's MPOWER package of effective country-level policies. Unfortunately, only 15% of the world's population have access to appropriate cessation support (WHO, 2015). Moreover, parties to the FCTC have implemented only 51% of the indicators within Article 14, on average, which is far lower than many other articles (WHO, 2014). Further, commenting on the use of “O” measures (Offer help to quit tobacco use) in the MPOWER acronym, WHO recently concluded, “while there has been improvement in implementing comprehensive tobacco cessation services, this is nonetheless a most under-implemented MPOWER measure in terms of the number of countries that have fully implemented it” (WHO, 2015). To the detriment of global tobacco control efforts, only one in eight countries provides comprehensive cost-covered services, only one in four provide some cost coverage for nicotine replacement therapy, and fewer than one third provide a toll-free quit line (WHO, 2015).

Recently in the Lancet, three renowned global tobacco control experts—Martin Raw, Judith Mackay, and Srinath Reddy—recommended that it is “time to take tobacco treatment seriously,” and they urged that FCTC parties implement Article 14 guidelines and “prioritise measures that will reach their entire populations, using measures that are affordable” (Raw, Mackay, & Reddy, Reference Raw, Mackay and Reddy2016).

This theme issue of the Journal of Smoking Cessation demonstrates that tobacco treatment, and research to support effective treatment, is being taken seriously in several low- and middle-income countries (LMICs). Several case studies and original empirical contributions from prominent tobacco intervention research groups working in LMICs, as well as international funders, highlight the important work being conducted in several global quarters, and share important lessons learned to help guide future work.

In his commentary for this theme issue, Professor Harry Lando reminds us that “providing tobacco cessation treatment is feasible even in countries with the fewest resources”, and he does a laudable job of recommending a path forward to accomplish this (Lando, Reference Lando2016). He places strong emphasis on building capacity for research and treatment, and disseminating low cost cessation strategies. There is a growing body of evidence supporting low cost nation-wide cessation interventions, including national automated text message support programs, which have been successfully implemented recently in Costa Rica (Gomez, Reference Gomez2015), the low-cost medication Cytisine (Walker et al., Reference Walker, Howe, Glover, McRobbie, Barnes and Nosa2014; West et al., Reference West, Zatonski, Cedzynska, Lewandowska, Pazik and Aveyard2011), and routinizing the delivery of brief cessation advice during healthcare encounters (West et al., Reference West, Raw, McNeill, Stead, Aveyard and Bitton2015).

The papers in this theme issue describe many challenges and successes around the globe in building capacity and adapting, evaluating, and disseminating effective treatments in LMICs. One strikingly common challenge is how to effectively integrate brief cessation counselling into healthcare practice. Patients view physicians as highly credible interventionists. However, although physicians can help patients quit (West et al., Reference West, Raw, McNeill, Stead, Aveyard and Bitton2015), as a profession, they do not consistently or effectively provide cessation services (Abdullah & Husten, Reference Abdullah and Husten2004; Aung et al., Reference Aung, Yuasa, Moolphate, Kitajuma, Fukuda and Lorga2014). The problem is multi-layered: many LMICs have high rates of tobacco use by physicians and other healthcare providers (Abdullah, Qiming, Pun, Stillman, & Samet, Reference Abdullah, Qiming, Pun, Stillman and Samet2013, Abdullah et al., Reference Abdullah, Stillman, Yang, Luo, Zhang and Samet2014; Asfar, Al-Ali, Ward, Vander Weg, & Maziak, Reference Asfar, Al-Ali, Ward, Vander Weg and Maziak2011), which make them reluctant to champion their patients’ quit attempts. Beyond this motivational issue, many physicians are skeptical that patients want their advice to quit smoking (Ossip et al., Reference Ossip2016; Prucha et al., Reference Prucha, Fisher, McIntosh, Grable, Holderness and Thevenet-Morrison2015), do not view cessation as part of their jobs (Dozier et al., Reference Dozier, Ossip, Diaz, Sierra-Torres, Quinones de Monegro and Armstrong2009; Tee, & Hairi, & Hairi, Reference Tee, Hairi and Hairi2012), and misunderstand the harms of tobacco (Abdullah & Husten, Reference Abdullah and Husten2004; Asfar et al., Reference Asfar, Al-Ali, Ward, Vander Weg and Maziak2011; Dogar, Elsey, Khanal, & Siddiqi, Reference Dogar, Elsey, Khanal and Siddiqi2016; Lando, Reference Lando2016).

Medical students have similar knowledge deficits as their mentors about cigarette smoking (Dania, Ozoh, & Bandele, Reference Dania, Ozoh and Bandele2015; Jradi & Al-Shehri, Reference Jradi and Al-Shehri2014), and about emerging tobacco use methods, such as waterpipe (Alzayani & Hamadehm, Reference Alzayani and Hamadehm2015; Babar & Riaz, Reference Babar and Riaz2015). An obvious solution is to educate and train physicians in tobacco treatment early in their careers. The first step is to discourage medical students from using tobacco given that many physicians begin smoking during medical school (Abdullah et al., Reference Abdullah, Stillman, Yang, Luo, Zhang and Samet2014; Alzayani & Hamadehm, Reference Alzayani and Hamadehm2015; Senol, Donmez, Turkay, & Aktekin, Reference Senol, Donmez, Turkay and Aktekin2006). It also is important to improve tobacco treatment training in medical schools, but this is challenging. A recent group-randomized trial of tobacco treatment education in 10 US medical schools found little evidence that an intensive multi-modal curriculum (a web-based course, classroom demonstrations, and a clerkship booster session) improved treatment delivery skills compared to traditional (and less intensive) brief, didactic tobacco education (Ockene et al., Reference Ockene, Hayes, Churchill, Crawford, Jolicoeur and Murray2016). There have been some recent efforts to improve tobacco training among medical and other healthcare professional students in LMICs, such as Project Quit Tobacco in India and Indonesia (Nichter, Nichter, & Muramoto, Reference Nichter, Nichter and Muramoto2010) and the Smokescreen Education Program in China (Richmond, Reference Richmond2004). However, researchers need to evaluate the effectiveness of these programs, and adapt them to different cultural settings.

Bolstering healthcare providers’ motivation and skills is only one of several useful approaches to improve tobacco treatment in LMICs (Raw et al., Reference Raw, Mackay and Reddy2016; WHO, 2008), but it represents “low hanging fruit” in terms of cost-effectiveness and reach. This theme issue highlights progress on several fronts that is relevant to efforts to better integrate tobacco treatment into healthcare. Global Bridges is a global alliance of healthcare providers to expand the reach of evidence-based tobacco dependence treatment, and to facilitate implementation of FCTC Article 14 (Kemper et al., Reference Kemper2016). Funded by Pfizer Medical Education Group and organized by Mayo Clinic, in its five years of existence, Global Bridges has trained more than 22,000 healthcare providers in 62 countries (e.g., Hawari & Bader, Reference Hawari and Bader2014). A major goal of Global Bridges is to foster communication amongst network members to achieve broad reach; early evidence indicates this is being accomplished (Leischow et al., Reference Leischow2016). Ever-improving technology makes global communication easier, and lowers the cost of training interventionists and intervention researchers. Global Bridges has created a multilingual website and virtual community (www.globalbridges.org), and this and other systems are being used to remotely train, supervise, and mentor tobacco interventionists (Asfar, Ward, Al-Ali, & Maziak, Reference Asfar, Ward, Al-Ali and Maziak2016; Selby et al., Reference Selby, Goncharenko, Barker, Fahim, Timothy and Drogonetti2015). Another web-based resource, www.treatobacco.net, sponsored by the Society for Research on Nicotine and Tobacco and the Society for the Study of Addiction, is likewise building treatment capacity by sharing evidence-based treatment approaches. These important initiatives are improving healthcare providers’ motivation, resources, and skills, thereby helping to make tobacco dependence treatment a routine part of healthcare encounters around the globe.

Even with state-of-the art technological support, a continuing challenge is that evidence-based interventions developed in high-income countries are often not appropriate in LMIC settings without substantial adaptation (Asfar et al., Reference Asfar, Ward, Al-Ali and Maziak2016; Dogar et al., Reference Dogar, Elsey, Khanal and Siddiqi2016). Asfar et al., Reference Asfar, Ward, Al-Ali and Maziak2016 describe how empirically supported behavioural cessation strategies developed and widely used in the US and UK, such as self-monitoring, nicotine fading, and social support enhancement, are not acceptable or useful in Syria. Likewise, studies from Pakistan and Syria suggest that adding pharmacotherapy to behavioural support in “real world” healthcare settings may not boost cessation rates beyond what is achievable by behavioural support alone (Asfar et al., Reference Asfar, Ward, Al-Ali and Maziak2016; Dogar et al., Reference Dogar, Elsey, Khanal and Siddiqi2016).

There is still much to be done, and many challenges remain. As Professor Lando reminds us (Lando, Reference Lando2016), tobacco intervention does not occur in a vacuum. Efforts to help smokers quit are more successful when linked to other tobacco control strategies, such as product labelling (Baskerville et al., Reference Baskerville, Brown, Nguyen, Hayward, Kennedy and Hammond2016; Li et al., Reference Li, Fathelrahman, Borland, Omar, Fong and Quah2016) and community engagement (Ossip et al., Reference Ossip2016). Additionally, rigorous intervention research is needed in LMICs to adapt treatment approaches from other settings as well as develop, test, and disseminate “home grown” treatments that are appropriate to the specific culture and context. While funding for tobacco intervention research historically has been a challenge (Lando, Reference Lando2016), funders such as the US National Institutes of Health (NIH), Cardiovascular Health Research in the Developing Countries (IC-Health), and Research for International Tobacco Control (RITC) have made important contributions. NIH has provided substantial on-going support through several initiatives, including its International Tobacco and Health Research and Capacity Building Program, which was spearheaded by Fogarty International Center and supported by several other NIH institutes including the National Institute on Drug Abuse and the National Cancer Institute (Parascandola et al., Reference Parascandola2016; Primack et al., Reference Primack, Bloch, Haverkos, Gust, Hare and Smith2006). This theme issue highlights the impressive progress these investments have generated and lessons learned to ensure that tobacco intervention continues to be front and centre in global tobacco control efforts.