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18 Aseptic meningitis, sensorineural hearing loss induced by simultaneous use of ibuprophen and ciprofloxacin

Published online by Cambridge University Press:  24 June 2014

Sepčić Juraj,
Materljan Eris,
Šepić Grahovac Dubravka and
Jurjević Ante
Sepčić Juraj
Affiliation:
Postgraduate Study
Materljan Eris
Affiliation:
Department of Family Medicine
Šepić Grahovac Dubravka
Affiliation:
Department of Neurology, School of Medicine, University of Rijeka, Brace Branchetta 20, 51000 Rijeka, Croatia, E-mail: erismaterljan@net.hr
Jurjević Ante
Affiliation:
Department of Neurology, School of Medicine, University of Rijeka, Brace Branchetta 20, 51000 Rijeka, Croatia, E-mail: erismaterljan@net.hr
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Abstract

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Introduction/Objectives:

Aseptic meningitis (AM), with or without other drug-induced neurological disorders, has been the subject of several reviews.

Participants, Materials/Methods:

We report clinically rare and serious adverse reactions that occurred after the co-administration of Ibuprofen and Ciprofloxain: completely reversible aseptic meningitis and irreversible bilateral sensorineural hearing loss, tinnitus, and vestibulopathy.

Results:

Recurrent urinary inflammations treated with antibiotics, classic migraine, and allergy to trimethoprim-sulfamethoxazole and chromium were favourable predisposing factors for the adverse event in this patient. A close chronological relation between administration of drugs (especially Ibuprofen) and adverse reactions was noted. No evidence of infection and/or autoimmune disease was found.

Conclusions:

The mechanism of these serious events may be explained as a hypersensitive reaction affecting the meninges and, partially, cochlea.