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Rise of the beta-lactams: a retrospective, comparative cohort of oral beta-lactam antibiotics as step-down therapy for hospitalized adults with acute pyelonephritis

Published online by Cambridge University Press:  26 July 2024

Athena L.V. HobbsOpen the ORCID record for Athena L.V. Hobbs[Opens in a new window],
Vagish S. Hemmige,
Katie L. Reel,
Theresa C. Jaso,
Dusten T. RoseOpen the ORCID record for Dusten T. Rose[Opens in a new window] and
Katherine M. Shea
Athena L.V. Hobbs*
Affiliation:
Cardinal Health Innovative Delivery Solutions, Stafford, TX, USA
Vagish S. Hemmige
Affiliation:
Department of Medicine, Montefiore Medical Center, Bronx, NY, USA
Katie L. Reel
Affiliation:
Department of Pharmacy, Sentara Healthcare, Virginia Beach, VA, USA
Theresa C. Jaso
Affiliation:
Department of Pharmacy, Ascension Seton Medical Center, Austin, TX, USA
Dusten T. Rose
Affiliation:
Department of Pharmacy, Ascension Dell Seton Medical Center-UT, Austin, TX, USA
Katherine M. Shea
Affiliation:
Cardinal Health Innovative Delivery Solutions, Stafford, TX, USA
*
Corresponding author: Athena L.V. Hobbs; Email: Athena.Hobbs@cardinalhealth.com

Abstract

Objective:

The aim of this study was to determine if oral beta-lactam therapy is non-inferior to alternative therapy at discharge following inpatient treatment with an IV cephalosporin for acute pyelonephritis.

Design:

Institutional Review Board (IRB)-approved, multicenter, retrospective, non-inferiority cohort (15% non-inferiority margin).

Setting:

Six hospitals within two healthcare systems.

Patients:

Hospitalized patients admitted to the medical floor with acute pyelonephritis without urologic abnormalities who received cefazolin or ceftriaxone followed by step-down therapy.

Methods:

Patients were discharged with either an oral beta-lactam or an oral alternative agent (ie, fluoroquinolone or trimethoprim-sulfamethoxazole) to complete therapy. The primary objective was treatment failure defined as a composite of hospital readmission or an ED visit for a urinary cause within 30 days of discharge of the index hospitalization. Data were extracted manually from the electronic medical record.

Results:

A total of 211 patients were included; 122 received an oral beta-lactam and 89 received an oral alternative agent at discharge. There was no difference in 30-day treatment failure between the two groups (4.9% vs 5.6% for oral beta-lactams vs oral alternatives, respectively. Absolute difference = 0.7%; 95% CI -5.4% to 6.8%; P = .82). The median length of hospital stay, number of patients treated with intravenous ceftriaxone, duration of IV therapy, and median duration of oral therapy were no different between groups.

Conclusions:

In non-ICU patients admitted for pyelonephritis without urologic abnormalities, oral beta-lactams were non-inferior to oral alternatives for step-down therapy. In finding non-inferiority between the regimens, we show the feasibility of administering oral beta-lactams to complete therapy for acute pyelonephritis.

Information

Type
Original Article
Information
Antimicrobial Stewardship & Healthcare Epidemiology , Volume 4 , Issue 1 , 2024, e102
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America

Introduction

Patients hospitalized for pyelonephritis traditionally receive intravenous antimicrobial therapy with transition to guideline-recommended non-beta-lactam oral therapies (eg, fluoroquinolone, trimethoprim/sulfamethoxazole [TMP/SMX]). Reference Gupta, Hooton and Naber1 However, due to increasing antimicrobial resistance (AMR) to primary recommended oral therapies and the Food and Drug Administration (FDA) boxed warnings for fluoroquinolones, there is heightened interest in the utility of oral beta-lactams as step-down therapy for treatment of pyelonephritis requiring hospitalization. 2 Additionally, de-escalation and intravenous-to-oral conversion via step-down therapy are important antimicrobial stewardship interventions to optimize antibiotic prescribing. 3 Application of antimicrobial stewardship in the management of urinary tract infections (UTIs) including pyelonephritis, can help mitigate the effects of AMR.

The 2010 Infectious Diseases Society of America (IDSA) and European Society for Microbiology and Infectious Diseases (ESCMID) guideline for acute uncomplicated UTIs and pyelonephritis recommends oral agents (ie, fluoroquinolones, TMP/SMX) for patients not requiring hospital admission. Reference Gupta, Hooton and Naber1 Empiric therapy with fluoroquinolones should be avoided in areas where local AMR rates are >10% to fluoroquinolones, yet North American susceptibility data indicates that E.coli exhibit 71.8% and 71.5% susceptibility to levofloxacin and ciprofloxacin, respectively. Reference Mathai, Jones and Pfaller4 Likewise, TMP/SMX is recommended only in areas where local AMR rates are <20% or if the uropathogen is known to be susceptible; however, the susceptibility rate for TMP/SMX is only 76.7% in North America. Reference Bouchillon, Badal, Hoban and Hawser5 IDSA/ESCMID guidelines caution that oral beta-lactams are less effective for the treatment of pyelonephritis, and recommendations regarding oral step-down antibiotic therapy for hospitalized patients are lacking.

Investigators sought to assess the impact of oral step-down beta-lactam therapy compared to an alternative oral agent (fluoroquinolone or TMP/SMX) in patients with acute pyelonephritis requiring hospitalization.

Patients and methods

Study design

This multicenter, retrospective, non-inferiority cohort included hospitalized patients with acute pyelonephritis in six hospitals (one academic medical center and five community hospitals) within two healthcare systems who received an IV cephalosporin (ie, ceftriaxone or cefazolin) followed by step-down therapy with either an oral beta-lactam or an oral alternative agent (ie, fluoroquinolone or TMP/SMX). A local inpatient UTI clinical pathway was implemented in all but one community hospital in May 2009. The clinical pathway provided oral antibiotic treatment options for UTIs based on isolated organism(s). For Escherichia coli, Klebsiella spp., and Proteus spp., recommended oral agents included amoxicillin, cephalexin, amoxicillin/clavulanate, TMP/SMX, and fluoroquinolones based on susceptibility of the isolated organism(s).

ICD-9 codes (590.8, 590.9, 590.10, 590.11) were used to identify patients with an admission diagnosis of acute pyelonephritis between January 1, 2014 and December 31, 2016. This study was approved by the institutional review boards of both healthcare systems. The primary outcome was treatment failure defined as a composite of hospital readmission or an ED visit for a urinary cause within 30 days of discharge of the index hospitalization. Urinary cause was defined as anything relating to the genitourinary system. Secondary outcomes included 90-day treatment failure as well as 30- and 90-day hospital readmission and ED visits for any reason.

Data collection

Demographic, infectious etiology, treatment, and outcomes clinical data were obtained from the inpatient electronic medical record. All data were extracted into a standardized form through manual chart review by four co-authors. Charlson Comorbidity Index data were also collected at baseline to evaluate and compare comorbid conditions between the groups. Baseline is defined as the first value documented in the electronic medical record upon initial admission unless otherwise specified.

In the event that a data point was not available in the patient’s chart, it was assumed that the patient did not meet criteria for said disease state captured in the Charlson Comorbidity Index. Temperature (minimum and maximum when more than one was available within a 24-hour time period) was recorded at baseline and within every 24-hour time period up to 5 days. Data for any hospital readmission or ED visit were collected throughout the Ascension Seton Health Alliance and the Baptist Memorial Healthcare Corporation to account for visits at any facility within those healthcare systems. Hospital readmission data for patients in the Austin, Texas area were also gathered through iCare, a local readmission documentation collaboration between hospitals in the Austin, Texas area to account for hospital readmissions at local hospitals outside the Ascension Seton Health Alliance.

Study patients

Patients were included if they were between the ages of 18 and 89 years, had an admission diagnosis of acute pyelonephritis, and received at least 24 hours of an intravenous (IV) cephalosporin (ceftriaxone or cefazolin) followed by step-down therapy with either an oral beta-lactam or an oral alternative agent (ciprofloxacin, levofloxacin, or TMP/SMX). Of note, inpatient antibiotic duration was calculated as anticipated duration of systemic concentrations of active drug (eg, 72 hours if patient received three doses of ceftriaxone).

Patients were excluded if they were pregnant; were admitted to the intensive care unit (ICU); received more than one dose of another individual IV antibiotic with Gram-negative activity prior to receiving the IV cephalosporin; received a discharge antibiotic other than an oral beta-lactam, fluoroquinolone, or TMP/SMX; were transferred from an outside hospital when records were not available; had another source of infection (other than bacteremia due to urinary source); or either did not have a baseline fever (temperature >100.3°F) or elevated serum white blood cell (WBC) count (WBC ≥12 X109 cells/L) plus urinary symptoms recorded. Patients were also excluded if they had a urological abnormality that is known to increase the risk of treatment failure including urethral strictures, renal stents, congenital abnormalities, renal cysts, neurogenic bladder, renal calculi, vesicoureteral reflux, renal abscess, or a suprapubic catheter.

Statistical analysis

An a priori one-sided test of non-inferiority revealed that 89 patients were required in each group to achieve 80% power with a non-inferiority margin of 15% and assuming a cure rate of 85% as reported in previous literature. Reference Cattrall, Robinson and Kirby6 Patients were collected in a reverse chronological order until power was met in both groups. Beta-lactams were considered non-inferior if the 95% confidence interval margin did not cross −15%. Categorical data were analyzed using Chi-squared or Fisher’s exact test, and continuous data were analyzed using Wilcoxon rank sum or T-test as appropriate. A multivariate logistic regression analysis was performed in a secondary analysis using the primary outcome as the dependent variable with potential confounders included as independent variables. R statistical software was used to conduct all statistical analyses. 7

Results

A total of 211 patients were included in the study; 122 received an oral beta-lactam and 89 received an oral alternative agent at discharge. Baseline characteristics were similar between groups other than mean age and female sex (Table 1). Patients were predominantly young females with fewer comorbidities. Additionally, the median duration of IV cephalosporins was roughly 3 days in both groups with a median duration of 7–10 days of oral antibiotics prescribed at discharge.

Table 1.

Demographic, clinical, and treatment characteristics

Results are presented as mean ± standard deviation unless otherwise specified. Baseline temperature is the maximum temperature within 24 hours of initiation of antibiotics. The first value in the first 24-hour period from admission was used for other baseline vitals. IV antibiotic was either cefazolin or ceftriaxone.

IQR, interquartile range; CT, computed tomography; US, ultrasound; WBC, white blood cell; °F conversion to °C = (temperature in °F – 32) * 5/9.

The urinary pathogens isolated in each group consisted primarily of E. coli (58%) and are depicted fully in Figure 1. Notably, only five patients did not have a urine culture performed. 50% of patients who received an oral beta-lactam at discharge received cefuroxime, followed by cephalexin/cefadroxil (24%), and amoxicillin +/- clavulanate (19%). 78% of patients who received an alternative oral antibiotic received a fluoroquinolone at discharge (Figure 2).

Figure 1.

Urinary isolates.

Figure 2.

Discharge oral antibiotic choice.

There was no difference in 30-day treatment failure when comparing the two groups (4.9% vs 5.6% for oral beta-lactams vs. oral alternatives, respectively. Absolute difference = 0.7%; 95% CI −5.4% to 6.8%; P = .82; Table 2). There was also no difference in 90-day treatment failure due to a urinary cause when comparing patients discharged on oral beta-lactams vs oral alternatives. Likewise, there was no difference between groups when evaluating either 30- or 90-day all-cause treatment failure. These findings persisted when potential confounders were controlled for in the multivariate logistic regression (Table 3).

Table 2.

Outcomes

*Treatment failure is defined as a composite of hospital readmission or ED visit.

Table 3.

Adjusted outcomes using multivariate logistic regression

*Perfect predictor for at least one level; at least some observations dropped.

Baseline temperature is the maximum temperature within 24 hours of initiation of antibiotics; CT, computed tomography; WBC, white blood cell; °F conversion to °C = (temperature in °F – 32) * 5/9.

Discussion

These findings suggest that step-down therapy with oral beta-lactams (eg, cefuroxime, cephalexin, and amoxicillin/clavulanate) for the treatment of hospitalized patients with pyelonephritis provides similar outcomes as oral fluoroquinolones and TMP/SMX. The 2010 IDSA/ESCMID international practice guideline recommendations do not address oral beta-lactam step-down therapy and refer back to the 1999 UTI guidelines that state beta-lactams are not as efficacious for pyelonephritis based on four randomized controlled trials from the 1980s and early 1990s. Two of these studies used oral ampicillin in the beta-lactam arm, another only evaluated microbiologic response, and the last compared a short beta-lactam duration of therapy. Reference Johnson, Lyons and Pearce8–Reference Jernelius, Zbornik and Bauer11 In addition to all of these being very small studies, they were plagued by significant limitations including the low bioavailability of oral ampicillin, the reliance on microbiologic cure alone instead of also evaluating clinical cure, and a shorter than required duration of therapy for beta-lactams. Interestingly, when presented at IDWeek 2023, the draft IDSA clinical practice guidelines for the treatment of complicated urinary tract infections, including pyelonephritis, recommend conversion to oral therapy (including beta-lactams with good urinary excretion at highest labeled dose) in patients with clinical improvement, hemodynamic stability, and source control. Reference Trautner and Cortes-Penfield12

Published literature specifically evaluating oral step-down therapy for the treatment of pyelonephritis is limited to three small, prospective, randomized studies. When comparing IV ceftriaxone (n = 41) vs oral cefditoren (n = 41) as step-down therapy after 3 days of IV ceftriaxone, there was no difference in clinical cure 95.1% vs 100%, respectively (p=0.15). Reference Monmaturapoj, Montakantikul, Mootsikapun and Tragulpiankit13 Similarly, when comparing IV ceftriaxone (n = 54) vs oral cefixime (n = 51) after receiving 24 hours of IV ceftriaxone, rates of clinical cure were similar between the two groups 91% vs 92%, respectively (P = 1). Reference Sanchez, Collvinent and Miro14 Finally, when comparing oral ceftibuten (n = 79) vs oral norfloxacin (n = 79) after receiving 2–4 days of IV cefuroxime, rates of clinical success were similar 82% vs 92%, respectively (95% CI 0.81–1), though there were fewer microbiologic relapses in the norfloxacin group (11%) versus the ceftibuten group (25%), P < 0.05. Reference Cronberg, Banke and Bergman15 The first of these studies defined clinical cure as the absence of dysuria or symptoms of pyelonephritis, while the latter two studies defined clinical cure as resolution of urinary symptoms including flank pain as well as resolution of fever. Reference Jernelius, Zbornik and Bauer11–Reference Cronberg, Banke and Bergman15

Although neither specifically assessed use of oral beta-lactams for step-down therapy, two additional retrospective studies found similar outcomes when assessing the use of oral cephalosporins compared to fluoroquinolones and TMP/SMX for treatment of pyelonephritis. A retrospective chart review by Lin and colleagues found no difference in the composite outcome of treatment failure within 30 days between oral cephalosporins and fluoroquinolones (15.3% vs 17.4%). Of note, 92.5% of patients received initial intravenous therapy for 1–2 days. Reference Lin, Zahlanie, Ortwine, Wei, Mang and Prokesch16 Likewise, Fosse et al. performed a retrospective observational cohort study and found no significant difference in UTI recurrence at 30 days between use of an oral cephalosporin versus an alternative agent (16% vs 17%; P = 0.851). Additionally, treatment with an oral cephalosporin was not identified as a significant risk factor for UTI recurrence (OR = 0.91, 95% CI 0.56–1.50; P = 0.722). Reference Fosse, Brinkman, Brink, Conner, Aden and Giancola17 These studies provide limited data that the use of oral cephalosporins, typically after initial IV administration, may be an oral option for the treatment of pyelonephritis.

Additionally, four retrospective cohort studies have assessed the impact of oral beta-lactams as step-down therapy for treatment of bacteremia due to a urinary source. Reference Sutton, Stevens, Chang, Khader, Timbrook and Spivak18–Reference Alzaidi, Veillette and May21 Three of the four studies found no significant difference in mortality and/or recurrence between oral beta-lactams and either fluoroquinolones or TMP/SMX after a median of 4–5 days of IV therapy; however, these studies may have been underpowered to detect a difference. Reference Sutton, Stevens, Chang, Khader, Timbrook and Spivak18–Reference Geyer, VanLangen, Jameson and Dumkow20 Alzaidi and colleagues found a non-significantly higher risk of recurrence (aHR 2.19 [0.95–5.01]) in patients who received highly bioavailable beta-lactams (amoxicillin, amoxicillin/clavulanate, cephalexin) vs non-beta-lactams; however, 70% of these patients were not optimally dosed for the treatment of bacteremia and received only a median of 3 days of IV therapy prior to oral conversion. Reference Alzaidi, Veillette and May21 These studies demonstrate promise for the use of oral beta-lactams as step-down therapy for bacteremia due to a urinary source. However, due to the lack of reported patients with pyelonephritis in these studies, generalizability to this patient population is limited.

Strengths/Limitations

This is the largest study comparing clinical outcomes for oral step-down therapy which was also powered to determine a difference in the primary outcome of treatment failure. Based on the available clinical data and anecdotal observations, we explored the effectiveness of oral beta-lactams for step-down therapy in light of high rates of AMR to first-line therapy described in current guidelines.

Patients with urological abnormalities were excluded from this study in an effort to limit confounders outside of antibiotic therapy alone that could influence treatment failure. Like most real-world studies, microbiologic and clinical cure could not be confirmed after patients were discharged. Thus, investigators assessed hospital readmission or ED visits as a surrogate for treatment failure. Though this captures potential 30-day hospital visits, we were unable to ascertain whether patients experienced less severe urinary symptoms that did not require a hospital visit. Furthermore, hospital readmission and ED visit data for one large community hospital in Memphis was limited to the 22 hospitals within that healthcare system. Despite this limitation, the majority of patients (90%) were treated at one of the five hospitals in Austin, Texas where investigators had access to a community-wide collaborative data share and were able to capture readmissions or ED visits to any local hospital in the area. However, due to the nature of this data collection, some patients could have experienced a hospital admission or ED visit outside the included hospitals.

Like most studies evaluating acute pyelonephritis, the majority of patients in this study were young females with limited comorbidities, which may limit the extrapolation of this data to the male and elderly population. Additional limitations to clinical application include patients with urologic abnormalities and immunocompromise as these comorbidities were not assessed. Oral antibiotic susceptibility was also unable to be assessed due to the lack of many oral beta-lactams on commercially available susceptibility panels. The Clinical Laboratory and Standards Institute provides susceptibility interpretation for several oral cephalosporins based on utilizing cefazolin as a surrogate for uncomplicated cystitis; however, recommendations and guidance are lacking regarding susceptibility inference for the treatment of pyelonephritis. 22 Finally, as a retrospective study, the step-down therapy antibiotic selection, timing, and dosing were at the discretion of the prescriber. We relied on accurate and consistent documentation in the electronic medical record including discharge antibiotic choice, dose, and duration, as we had no way to verify that prescriptions were filled or taken by patients.

Clinical implications

This is the largest comparative study evaluating clinical outcomes of beta-lactam oral step-down therapy for acute pyelonephritis. In non-ICU patients without urologic abnormalities, oral beta-lactams were non-inferior to an oral alternative for step-down therapy for hospitalized patients with pyelonephritis. Finding non-inferiority between the regimens demonstrates the feasibility of administering oral beta-lactams in light of current AMR as well as FDA-boxed warnings for fluoroquinolones. Investigators hope that this retrospective cohort study provides an opportunity for antimicrobial stewardship optimization in utilizing oral beta-lactams for step-down treatment of pyelonephritis but recognize that randomized, controlled trials are needed to strengthen the level of evidence.

Acknowledgments

None.

Author contributions

ALVH: Conceptualization, data curation, formal analysis, methodology, project administration, supervision, validation, visualization, writing-original draft, writing-review, and editing.

VSH: Conceptualization, formal analysis, methodology, validation, writing review, and editing.

KLR: Data curation, formal analysis, validation, and visualization.

TCJ: Conceptualization, data curation, methodology, validation, visualization, writing review, and editing.

DTR: Conceptualization, data curation, methodology, validation, visualization, writing review, and editing.

KMS: Conceptualization, methodology, project administration, supervision, visualization, writing review, and editing.

Financial support

This study was not externally funded as it was conducted as part of the investigators’ routine work.

Competing interests

None to declare.

Research transparency and reproducibility

Databases are not publicly available.

Footnotes

Previous Presentations: The preliminary report of this work was previously presented as an oral abstract at IDWeek 2019.

References

Gupta, K, Hooton, TM, Naber, KG, et al. International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the infectious diseases society of America and the European society for microbiology and infectious diseases. Clin Infect Dis 2011;52:e103–e120.CrossRefGoogle Scholar
JMI Laboratories (United States). SENTRY Antimicrobial Surveillance Program Data 2018-2022.Google Scholar
CDC. Core Elements of Hospital Antibiotic Stewardship Programs. Atlanta, GA: US Department of Health and Human Services, CDC; 2019. https://www.cdc.gov/antibiotic-use/core-elements/hospital.html.Google Scholar
Mathai, D, Jones, R, Pfaller, M. Epidemiology and frequency of resistance among pathogens causing urinary tract infections in 1,510 hospitalized patients: a report from the SENTRY antimicrobial surveillance program (North America). Diag Microbiol Infect Dis 2001;40:129–36.CrossRefGoogle ScholarPubMed
Bouchillon, S, Badal, R, Hoban, D, Hawser, SP. Antimicrobial susceptibility of inpatient urinary tract isolates of gram-negative bacilli in the United States. Clin Ther 2013;35:872–877.CrossRefGoogle ScholarPubMed
Cattrall, JWS, Robinson, AV, Kirby, A. A systematic review of randomised clinical trials for oral antibiotic treatment of acute pyelonephritis. Eur J Clin Microbiol Infect Dis 2018;37:2285–91.CrossRefGoogle ScholarPubMed
R Core Team (2023). R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing. http://www.R-project.org/ Google Scholar
Johnson, JR, Lyons, MF, Pearce, W, et al. Therapy for women hospitalized with acute pyelonephritis: A randomized trial of ampicillin versus trimethoprim-sulfamethoxazole for 14 days. J Infect Dis 1991;163:325–30.CrossRefGoogle ScholarPubMed
Stamm, WE, McKevitt, M, Counts, GW. Acute renal infection in women: treatment with trimethoprim-sulfamethoxazole or ampicillin for two or six weeks. A randomized trial. Ann Intern Med 1987;106:341–5.CrossRefGoogle ScholarPubMed
Ode, B, Broms, M, Walder, M, Cronberg, S. Failure of excessive doses of ampicillin to prevent bacterial relapse in the treatment of acute pyelonephritis. J Intern Med 1980;207:305–7.Google ScholarPubMed
Jernelius, H, Zbornik, J, Bauer, CA. One or three weeks’ treatment of acute pyelonephritis? A double-blind comparison, using a fixed combination of pivampicillin plus pivmecillinam. Acta Med Scand 1988;223:469–77.CrossRefGoogle ScholarPubMed
Trautner, B, Cortes-Penfield, N. (2023). Clinical Practice Guidelines for the Treatment of Complicated Urinary Tract Infection (cUTI) in Adults: What They Say, and How We Got There. [PowerPoint Presentation]. IDWeek 2023. Boston, MA, USA: Program – IDWeek.Google Scholar
Monmaturapoj, T, Montakantikul, P, Mootsikapun, P, Tragulpiankit, P. A prospective, randomized, double dummy, placebo-controlled trial of oral cefditoren pivoxil 400 mg once daily as switch therapy after intravenous ceftriaxone in the treatment of acute pyelonephritis. Int J Infect Dis 2012;16:e843–9.CrossRefGoogle Scholar
Sanchez, M, Collvinent, B, Miro, O, et al. Short-term effectiveness of ceftriaxone single dose in the initial treatment of acute uncomplicated pyelonephritis in women. A randomized controlled trial. Emerg Med J 2002;19:19–22.CrossRefGoogle Scholar
Cronberg, S, Banke, S, Bergman, B, et al. Fewer bacterial relapses after oral treatment with norfloxacin than with ceftibuten in acute pyelonephritis initially treated with intravenous cefuroxime. Scand J Infect Dis 2001;33:339–43.Google ScholarPubMed
Lin, K, Zahlanie, Y, Ortwine, JK, Wei, W, Mang, NS, Prokesch, BC. A retrospective review of oral cephalosporins versus fluoroquinolones for the treatment of pyelonephritis. PLoS ONE 2022;17:e0274194.CrossRefGoogle ScholarPubMed
Fosse, PE, Brinkman, KM, Brink, HM, Conner, CE, Aden, JK, Giancola, SE. Comparing outcomes among outpatients treated for pyelonephritis with oral cephalosporins versus first-line agents. Int J Antimicrob Agents 2022;59:106560.CrossRefGoogle ScholarPubMed
Sutton, JD, Stevens, VW, Chang, NN, Khader, K, Timbrook, TT, Spivak, ES. Oral β-lactam antibiotics vs fluoroquinolones or trimethoprim-sulfamethoxazole for definitive treatment of Enterobacterales bacteremia from a urine source. JAMA Netw Open 2020;3:e2020166.CrossRefGoogle ScholarPubMed
Saad, S, Mina, N, Lee, C, Afra, K. Oral beta-lactam step down in bacteremic E. coli urinary tract infections. BMC Infect Dis 2020;20:785.CrossRefGoogle ScholarPubMed
Geyer, AC, VanLangen, KM, Jameson, AP, Dumkow, LE. Outcomes of high-dose oral beta-lactam definitive therapy compared to fluoroquinolone or trimethoprim-sulfamethoxazole oral therapy for bacteremia secondary to a urinary tract infection. Antimicrob Steward Healthc Epidemiol 2023;8:e148.CrossRefGoogle Scholar
Alzaidi, S, Veillette, JJ, May, SS, et al. Oral beta-lactams, fluoroquinolones, or trimethoprim-sulfamethoxazole for definitive treatment of uncomplicated Escherichia coli or Klebsiella species bacteremia from a urinary source. Open Forum Infect Dis (in press). DOI: 10.1093/ofid/ofad657.Google Scholar
CLSI. Performance Standards for Antimicrobial Susceptibility Testing, 33 rd edition. CLSI M100-ED33. Clinical and Laboratory Standards Institute; 2023.Google Scholar
Figure 0

Table 1.Demographic, clinical, and treatment characteristics

Figure 1

Figure 1.Urinary isolates.

Figure 2

Figure 2.Discharge oral antibiotic choice.

Figure 3

Table 2.Outcomes

Figure 4

Table 3.Adjusted outcomes using multivariate logistic regression