The Clinical Breast Care Project (CBCP) conducts coordinated clinical care and research across military and civilian medical centers, requiring secure and integrated management of participant records and biospecimens. To support enrollment, biospecimen processing, and translational research in this specialized environment, the Data Tracking System for the Clinical Breast Care Project (DTS-CBCP) was developed.

DTS-CBCP collects participant, clinical, consent, pathology, and biospecimen metadata through a web-based platform. It uses a patient-centric model to connect clinical events with biospecimen data. Development utilized a tiered web-application architecture and an Oracle database environment that meet Department of War (DOW) and Health Insurance Portability and Accountability Act standards. Audit trails, encryption, and role-based access ensure secure multi-site participation. DTS-CBCP also integrates with the Data Warehouse for Translational Research (DW4TR), Freezerworks, and digital pathology tools.

DTS-CBCP has supported participant enrollment (n = 11,452) and biospecimen tracking (n = 104,671 specimens, including 18,974 frozen tissue and 9866 Formalin-Fixed Paraffin-Embedded samples). Additionally, 219,280 blood aliquots and 19,937 slides have been tracked across three military and civilian sites. The system enables consent tracking, clinical annotation, specimen chain-of-custody, remote digital pathology, and automated reporting. DTS-CBCP has supported breast cancer research initiatives such as The Cancer Genome Atlas and the Applied Proteogenomic Organizational Learning and Outcomes projects.

DTS-CBCP addresses coordination of clinical and biospecimen data across military and civilian institutions. In addition to supporting breast cancer research, it creates an informatics framework for expanded translational research networks and future DOW-aligned programs.