This essay examines the “dirty margins” where HIV/AIDS, cancer, and academic life intersect. Drawing on Paula Treichler’s concept of AIDS as an “epidemic of signification,” it traces forty years of living with HIV, including a near-fatal episode of Kaposi’s sarcoma (KS) in 1994 and over a decade of anal dysplasia—conditions rendered culturally legible through AIDS-era moral panic as much as through oncology. I write as autopathography, treating autobiography not as confession but as method, following Arthur W. Frank’s understanding of pathography as knowledge produced from embodied experience. Although KS did not recur, its long shadow shaped the temporal and affective terrain of survival. Moving from the whispered moralization of illness to the clinic’s production of the clinical self—the version of the body produced in medical records, and from academic domestication and erotic counterpractices to quantification, pharmacological society, and the social mirror, the essay traces how a misbehaving body is repeatedly threatened, written down, fragmented, managed, and measured—yet continues to theorize back. In these processes, minoritized bodies become hypervisible as research objects yet remain marginal as knowledge producers. Against triumphant scripts of biomedical progress, the essay assembles a counterarchive of resentment, erotic improvisation, and delayed care. The “dirty margins” of cancer, it argues, reside not only in diseased cells but also in the epistemic and institutional systems that metabolize marginalized bodies as spectacle, evidence, and compliance while refusing their authority as theory.