Radiocarbon dating of disarticulated human remains from Brading Roman villa (Isle of Wight, UK) assigns them to a single event or multiple events within a short duration in the Late Roman period, c. 220/50–360/400. The evidence of the coins suggests the possibility of a brief abandonment of the villa following a potentially murderous event in the 340s or 350s, perhaps to be linked to reprisals taken by Constantius against supporters of Magnentius. This event may in turn coincide with a significant reorganisation of space in the west range of the villa.