The article analyzes ethno-demographic trends in the contemporary Russian Federation, first of all, from the point of view of the probability of the development of separatist aspirations in ethnic autonomies within it. In recent decades, due to the shrinking opportunities to maintain the identity of indigenous peoples, assimilation processes have intensified among many of them (primarily the peoples of the Finno-Ugric group, as well as peoples whose is subjected to persecution in Russia, such as Ukrainians). Because of the assimilation, the share of the Russian ethnic majority in the country’s population is growing. At the same time, in the national republics of the North Caucasus and Siberia, the number of indigenous peoples is growing. In general, there is a process of ethnic separation: “Russian” regions are becoming ethnically more and more “Russian,” while 13 out of 21 republics are getting more and more “non-Russian.” Russian aggression in Ukraine also increases the likelihood of destabilizing Russia in the future, as the ideology of the “Russian World” politicizes inter-ethnic relations within Russia itself, making ethnic minorities second-class citizens.