Drug use among young women has severe consequences for their mental health, increases their developmental vulnerability and highlights the global problem of drug addiction. The purpose of this study was to investigate the socioeconomic and psychological factors influencing drug use among young women in Khyber Pakhtunkhwa, Pakistan. The study used a qualitative research design. We collected data from 12 women aged 18–21 years via in-depth qualitative interviews conducted in Mardan and Peshawar from March to June 2022. Research shows that young women frequently use drugs due to peer pressure, emotional challenges and financial concerns, which significantly impact their lives. The study emphasizes the value of cultural intervention programs for young women, concentrating on the region’s mental health services, economic empowerment and gender-specific peer support networks.