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1 results

  • Chapter 4 - Neuropathology of Dementia

  • from Section 1 - Introductory Chapters on Dementia
  • Edited by Bruce L. Miller, University of California, San Francisco, Bradley F. Boeve, Mayo Clinic, Minnesota
  • Book:
    The Behavioral Neurology of Dementia
    Published online:
    17 November 2025
    Print publication:
    11 December 2025, pp 42-74

  • Summary

    This chapter discusses the neuropathology of dementia, focusing on the degenerative dementia syndromes commonly encountered by dementia specialists. It highlights the concept of selective vulnerability, where specific neuron types in specific brain regions decline and die, leading to progressive dysfunction. Alzheimer’s disease (AD) is the most prevalent cause of dementia, characterized by neurofibrillary pathology and the presence of neuritic plaques and neurofibrillary tangles. Dementia with Lewy Bodies (DLB), multiple system atrophy (MSA), and frontotemporal dementia (FTD) are also discussed, along with their respective clinical features and underlying pathology. The chapter emphasizes the complexity of neurodegenerative diseases and the need for more integrative models to understand their pathogenesis and develop effective therapies.