To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Science is in the midst of an under-recognized revolution. For centuries, prediction in science went hand in hand with understanding: knowledge of what advanced in tandem with knowledge of how and why. But in recent years, AI tools have enabled scientists to make predictions that previously would have been impossible, even if they don't understand why those predictions hold true. Already, scientists have used these AI 'oracles' to design new drug candidates and help paralyzed people regain the ability to speak. These are consequential achievements. But they also raise a difficult question: If science can improve lives with prediction alone, should we still seek to understand the universe? In The Prediction Revolution, Grace Huckins, a trained neuroscientist and award-winning journalist, explores how AI is reshaping the relationship between prediction and understanding-and challenges us to consider what science is really for. This title is also available as open access on Cambridge Core.
The Introduction sets out the central question that this book aims to tackle: when, why, and how did we evolve the peculiar and paradoxical inclination for both war and peace that characterises our species? The book argues that the inclination for both intergroup coalitionary killing and peaceful cooperation have deep roots and that they co-evolved through a gradual, incremental trajectory over millions of years. This co-evolution unfolded in a mosaic-like pattern, with distinct but interacting components emerging at different moments and becoming integrated over evolutionary time.
When, why, and how did we, humans, develop our distinctive and paradoxical inclinations for both war and peace? This groundbreaking book investigates that central question by drawing on cutting-edge research and an unprecedented range of evidence from thirteen disciplines: biology, primatology, comparative ethology, behavioural ecology, anthropology, archaeology, criminology, social psychology, linguistics, demography, genetics, neuroscience, and climatology. The book shows how the capacities for both war and peace co-evolved gradually over millions of years through a mosaic-like pattern, with distinct but interacting components emerging at different moments and becoming integrated over evolutionary time. This deep-rooted trajectory has been shaped by feedback loops among biological, cultural, and environmental forces. With its expansive temporal horizon, cross-species comparisons, and empirical richness, this book offers a sweeping new account – and an indispensable resource – for anyone interested in the origins of the Janus-faced inclination for both war and peace in the human species.
Despite compelling epidemiological, genetic and cellular evidence linking immune dysregulation to depression and schizophrenia (and other psychotic disorders), causality remains contested and no immune biomarker has yet demonstrated robust clinical utility. Emerging methodological approaches – from target trial emulation on observational data to functional genomics – offer a potential path towards precision immunopsychiatry and stratified immunomodulatory treatment.
Educating medical students in the core skills of psychiatric examination and the implications of psychiatric comorbidities to medical care is of critical importance, given the increasing prevalence of a number of mental disorders and their increasing comorbidity with medical conditions. This article outlines psychiatry education in three of Singapore’s medical schools, where it forms a small yet integral part of the undergraduate and postgraduate curricula.
This chapter contrasts the growing acceptance of anger and grief in political theory with the persistent, one-sided pathologization of fear. While anger and grief are now frequently defended as politically valuable, fear is still dismissed as a primitive, irrational force threatening public life. Rather than defend fear, however, I criticise a pervasive argument against it, which relies on two dubious claims: (1) neuroscientific findings supposedly prove fear is inherently destructive in politics and (2) entire groups are driven by fear. I dispute the first claim by drawing on the work of LeDoux to show that ‘fear’ in neuroscientific research often differs fundamentally from the subjective experience of fear that critics often target. I dispute the second by arguing that attributions of fear to social groups and populations frequently hinge on weak evidence, such as conflating perceived threat with the emotional state of fear. Finally, I argue that the fear of fear in political theory is harmful. It fuels unwarranted attributions of fear that oversimplify the complexities of political behaviour and risk compounding the marginalisation of socio-economically disadvantaged people.
It is well-known that physical exercise brings a range of benefits for physical and mental health. This review specifically considers the impact of physical activity on mental health and focuses on the increasing knowledge of the neurobiological actions of exercise. It outlines the effects of stressors on physiology and, consequently, mental health and explores the concept of neuroplasticity. It assesses the wide-ranging evidence from animal and human studies consistent with exercise modulating neuroplasticity processes, such as stimulation of long-term potentiation, synaptic growth and neurogenesis. Mechanisms underpinning these effects are presented: stimulation of angiogenesis, production of neurotrophic factors, modulation of stress and inflammatory responses, metabolic adaptation and epigenetic modification. Finally, the relevance of the evidence base to clinical practice is considered. In particular, it is noted that discussion of these positive impacts of exercise on ‘brain health’ may increase motivation to participate in physical activity in some patients.
Beyond Words has been an introduction to psycholinguistics, the study of language and the mind. This field merges linguistics and psychology, as its name suggests, but it’s much more complicated than that. Psycholinguistics is a multidisciplinary science that also combines insights from philosophy, cognitive science, and neuroscience, among other areas. To get more granular, there are the branches of study that fall under the umbrella of this field, including first language acquisition, second language acquisition, language comprehension and production, and what happens when this all goes wrong. At first, it is baffling to fathom how so many different branches could possibly belong to a single field. However, as the story unfolded it revealed how these pieces all fit together to help us understand the ways that we learn, use, and lose language.
What are the key design elements of human language? How does it work? What makes it different from how animals communicate and convey information? How did it evolve, biologically speaking? In what respects do animals fail to do what we humans do so effortlessly? Language is a uniquely human trait, but without a degree in linguistics, it is difficult to comprehend how it works. This fascinating book addresses these and related questions in a lively and engaging way, and demonstrates the 'nuts and bolts' of how language actually works. Readers are introduced to key discoveries in the study of language, such as Chomsky's ideas about 'language faculty', and parallels are drawn with well-known issues in science, such as 'flat earth', the nature-nurture debate, and the teaching of language to apes. Language – something so universal to all human experience – is a fascinating cognitive system, and this book explains how, and why.
Chapter 7 begins with Kornblith’s attempt to resurrect a teleology of the mind or intellect. I countenance his semantic, desire and pragmatic arguments, maintaining that none of them shows truth or true belief to be an objective good. By contrast, Aristotle’s idea that the intellect is constitutively directed at truth does show this (in virtue of the Aristotelian functionalist schema: i.e. all functions are correlated with perfections or goods). And Aristotle’s idea is corroborated not only by ‘folk’ and theoretical psychology, but also by cognitive science. For the latter is wedded to the notion that the brain is a cognitive system, functionally directed at cognition (viz. true belief). I go on to address three critiques of this intellectual teleology – those put forward by William James, evolutionary biology and global scepticism respectively – and argue that none of them is cogent. Next, I unpack two alternative accounts of the relation between truth and goodness – those of Ayer and Davidson – and maintain that they, too, fall short. Last, I tackle intellectual goods beyond true belief – such as knowledge and understanding – asking whether they or their objects form discernible hierarchies.
Edited by
Katherine Warburton, California Department of State Hospitals, University of California, Davis, USA,Stephen M. Stahl, University of California, Riverside, USA
This article, titled “A Unified Understanding of the Human Mind - A Neuroethical Perspective,”examines the evolution of the concept of the human mind in Western thought and its integration with neuroscience, psychology, psychiatry, and relational dimensions. The author explores how the understanding of the mind has changed over time, influenced by shifts in philosophical paradigms, scientific advancements, and societal perspectives. The article traces the historical development of the mind’s concept, starting from ancient Greece, through influential thinkers like Plato and René Descartes, and progressing to contemporary perspectives. It highlights various philosophical and scientific approaches, including structuralism, functionalism, empiricism, and associationism, which have shaped our understanding of the mind. The article also delves into contemporary integration, where advancements in neuroimaging and the rise of holistic approaches offer a more nuanced understanding of the human mind. The author emphasizes the importance of the relational dimension and the interconnectedness of mental processes, the brain, and the external environment. This integrated perspective can benefit psychiatric treatment and psychological assessments by fostering a holistic approach to mental health. In conclusion, the article advocates for a multidimensional perspective that bridges subjective and objective aspects of human experience, offering promise for theoretical knowledge and practical applications in psychology, psychiatry, and neuroscience.
This chapter provides multiple-choice questions designed to reinforce and expand your knowledge of basic neuroscience, including synaptic neurotransmission, chemical neurotransmission, receptors, ion channels, enzymes, and the relationship between genes, environment, and behavior.
We need to identify novel, tractable therapeutic targets for anxiety disorders. Converging evidence suggests the endogenous opioid system plays a role in modulating affective processing, but its contribution to regulation of threat processing in humans remains unclear.
Aims
We investigated the neural correlates of non-specific opioid antagonism on explicit and implicit regulation of threatening stimuli in healthy volunteers, using functional magnetic resonance imaging (fMRI).
Method
In a randomised, double-blind, placebo-controlled, crossover design, 38 healthy participants received the opioid antagonist naltrexone (50 mg) or placebo before completing two tasks during fMRI: (a) a cognitive emotional reappraisal task probing explicit regulation and (b) a face-viewing task probing implicit processing.
Results
Contrary to our hypothesis, we found naltrexone reduced distress ratings during the reappraisal task (p = 0.044) without impairing regulation success. Explicit regulation in the reappraisal task engaged lateral prefrontal regions similarly across drug conditions. However, naltrexone attenuated ventromedial prefrontal cortex, thalamus and caudate activation when viewing negative images. Naltrexone additionally altered ventromedial prefrontal cortex activity and in task-positive regions including right premotor area and frontal pole compared with placebo when viewing emotional faces. In particular, naltrexone increased left middle frontal gyrus activity when viewing fearful faces.
Conclusions
Our results support a role for opioid signalling in automatic emotional regulation, but not in explicit regulation. Furthermore, naltrexone appeared to diminish activity in task-positive regions in response to emotional faces. These findings are consistent with a model where endogenous opioids ‘fine-tune’ affective responses to both negative and positive stimuli. Future research should explore dose–response effects, kappa-opioid contributions and whether similar results are seen in clinical populations.
Panic disorder is among the most common mental disorders, characterised by recurrent, unexpected panic attacks that are highly distressing and further lead to pervasive anxiety about future attacks and maladaptive behavioural changes. Existing pharmacological and psychological treatments often fail to produce lasting improvement, and relapse is common. Neither antidepressants, the current first-line drug treatments, nor benzodiazepines exert their actions sufficiently rapidly to head off panic attacks between the initial indications of panic symptoms and the fully developed panic attack. Therefore, there is a clear need for new pharmacological compounds, particularly those that could be administered at the first warning signs of an impending panic attack, to disrupt its genesis. Here we discuss the acid-sensing ion channel (ASIC) as a therapeutic target and the potential of amiloride, an ASIC antagonist administered via nasal spray, for rapid access to the brain, as a compound with potential to fill this need. We summarise relevant preclinical studies, including a demonstration of nebulised amiloride’s ability to normalise responses to carbon dioxide, a panicogenic, brain-acidifying agent. Following existing safety, stability and pharmacokinetic studies, clinical trials are needed to test the efficacy of this compound in individuals with panic disorder and/or recurrent panic attacks.
This clinical reflection explores the evolving landscape of teaching and training in old age psychiatry, highlighting recent reforms such as the 2022 UK curriculum revision, which emphasises person-centred, interdisciplinary and digitally enhanced care. It examines national and international initiatives addressing health inequalities, integration of artificial intelligence, and co-produced education. The article underscores the need for adaptable, inclusive and forward-thinking training to meet the complex mental health needs of an ageing global population.
Takes up another aspect of free will, the challenge of scientific determinism. I argue that Jewish tradition contains surprisingly many thinkers who either deny free will or (more commonly) greatly limit its scope, question its value, or embrace compatibilism (the thesis that free will and determinism are compatible). Some of what these thinkers say can be transferred to the challenge of determinism as it exists today.
This undergraduate biological psychology textbook offers a critical introduction to brain and behavior. Psychology lectures open with 'the brain is the most complex and mysterious object in the universe', only to quickly reduce that complexity by teaching simplified models. This textbook challenges these narratives by focusing on the latest neurotechnological advances, to clarify the limits of current models, and to inspire the development of safe and accessible technologies for human use. Its central aim is to promote critical thinking and inspire students to pose novel research questions that build from current advances. It is an ideal textbook for instructors who are eager to push beyond a conventional introductory curriculum. Beautifully illustrated and full of practical applications, it is accompanied by teaching slides and a test bank.
Most psychiatric disorders in adulthood originate in childhood or adolescence. Hence, managing mental health in children and adolescents is crucial. This clinical reflection aims to capture some of the contemporary and emerging trends in teaching and training in child and adolescent psychiatry worldwide. Future directions for child and adolescent psychiatry training programmes are also highlighted.