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1 results

  • SMARCB1-deficient sinonasal carcinoma: an updated systematic review and survival analysis

  • Owen Tsung Wen Ho, Beth Shi Yu Lim, Yah Ru Juang, Richmond Quan Qing Lim, Jian Li Tan
  • Journal:
    The Journal of Laryngology & Otology / Volume 140 / Issue 6 / June 2026
    Published online by Cambridge University Press:
    24 March 2026, pp. 594-605
    Print publication:
    June 2026
    • Article
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  • Objectives

    This study aims to provide an updated systematic review on the clinicopathological features, treatment modalities and survival outcomes on SMARCB1-deficient sinonasal carcinoma.

    Methods

    Five databases were searched: PubMed, Cochrane, Embase, Web of Science and Scopus. Extracted information include demographic data, clinicopathological characteristics and survival outcomes.

    Results

    A total of 70 studies were included making up a total of 372 patients. Univariable and multivariable analysis performed for prognostic factors of SDSC showed that N+ disease was a statistically significant poor prognostic factor for overall survival, while surgical treatment was a favourable prognostic factor. Treatment with surgery combined with chemotherapy and/or radiotherapy conferred significantly better prognosis compared to chemotherapy or radiotherapy alone.

    Conclusion

    Our study suggests that N+ disease and isolated treatment with radiotherapy or chemotherapy alone are significant poor prognostic factors for SMARCB1-deficient sinonasal carcinoma, while patients who undergo surgical treatment have significantly better prognosis.