This chapter examines actual but in particular imagined deserts of the Anthropocene as they have been portrayed in literature, while also making occasional forays into other cultural media like film, television, comics, and computer games. The chapter is divided into three sections titled Apocalyptic Desert, Toxic Desert, and Biospheric Desert, each section examining how Eurocentric ideologies, religious perspectives, financial models, as well as literary and cultural traditions have tended to paint the desert in the light of an existential struggle of “the human.” The chapter argues that when reading deserts from the perspective of the Anthropocene, it is important to undo any totalizing vision of the desert. The chapter points towards a wide range of desert texts like Walter M. Miller’s A Canticle for Leibowitz, J.G. Ballard’s The Drought, David Brin’s The Postman, and Edan Lepucki’s California, computer games like Spec Ops: The Line, and Homeworld: Deserts of Kharak, films like The Mad Max franchise, as well as comics like Judge Dredd and Tank Girl. The chapter concludes with an extended reading of Paolo Bacigalupi’s novel The Water Knife and Frank Herbert’s Dune.